Detailed information for compound 25472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.441 | Formula: C22H25N
  • H donors: 0 H acceptors: 0 LogP: 5.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1ccc2c(c1)C1CCC2C1)C/C=C/c1ccccc1
  • InChi: 1S/C22H25N/c1-23(13-5-8-17-6-3-2-4-7-17)16-18-9-12-21-19-10-11-20(15-19)22(21)14-18/h2-9,12,14,19-20H,10-11,13,15-16H2,1H3/b8-5+
  • InChiKey: BNUVAOXVCBRDMT-VMPITWQZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0432 0.0432
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0277 0.0664
Echinococcus granulosus FTZ F1 alpha 0.003 0.0277 0.0247
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.058 0.0551
Loa Loa (eye worm) hypothetical protein 0.0041 0.0446 0.0417
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0277 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0277 0.0266
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0277 0.0247
Schistosoma mansoni lamin 0.0059 0.0723 0.0694
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0122 0.0764
Brugia malayi hypothetical protein 0.0014 0.0031 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0594 0.0725
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0031 0.002
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0432 0.0402
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0277 0.0247
Mycobacterium ulcerans beta-lactamase 0.0074 0.0957 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0432 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1596 0.2147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0026
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.095 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0277 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0588 0.0558
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0057 0.0047
Brugia malayi Bromodomain containing protein 0.008 0.1052 0.1043
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Brugia malayi follicle stimulating hormone receptor 0.0252 0.3724 0.3718
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0169 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0406 0.0376
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.4085 0.4079
Schistosoma mansoni bromodomain containing protein 0.0068 0.0859 0.083
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0957 0.4131
Schistosoma mansoni lamin 0.0059 0.0723 0.0694
Brugia malayi hypothetical protein 0.0016 0.0057 0.0047
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0594 0.0565
Schistosoma mansoni thyroid hormone receptor 0.0164 0.236 0.2336
Schistosoma mansoni intermediate filament proteins 0.0059 0.0723 0.0694
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0136 0.0944
Echinococcus granulosus transcription factor Dp 1 0.0042 0.047 0.0441
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0059 0.0723 0.0694
Brugia malayi nuclear hormone receptor 0.0014 0.0031 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0277 0.0247
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0057 0.0026
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0235 0.0204
Echinococcus granulosus lamin 0.0059 0.0723 0.0694
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0277 0.0247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0094 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0134 0.1895 0.187
Schistosoma mansoni zinc finger protein 0.0021 0.0135 0.0105
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1596 0.2147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0277 0.0247
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0277 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0957 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0277 0.0266
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2766 0.6772
Schistosoma mansoni nuclear hormone receptor 0.003 0.0277 0.0247
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0136 0.1041
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0094 0.0063
Onchocerca volvulus 0.0074 0.0957 0.2503
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0136 0.0136
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.047 0.0441
Plasmodium vivax SET domain protein, putative 0.0032 0.0305 0.2814
Mycobacterium leprae Probable lipase LipE 0.0074 0.0957 0.4131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.058 0.0551
Echinococcus multilocularis musashi 0.0059 0.0723 0.0694
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0957 0.1241
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0094 0.0063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0957 0.1241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0277 0.0266
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0136 0.0332
Brugia malayi nuclear receptor NHR-88 0.003 0.0277 0.0266
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0957 0.0929
Echinococcus multilocularis lamin 0.0059 0.0723 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0588 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0277 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0277 0.0247
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0136 0.0608
Brugia malayi Inositol-1 0.004 0.0432 0.0422
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0957 1
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0723 0.0713
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0305 0.0275
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1795 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0799 0.0771
Brugia malayi Pre-SET motif family protein 0.0222 0.3255 0.3248
Mycobacterium tuberculosis Conserved protein 0.0074 0.0957 0.1241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.058 0.0551
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0083 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1596 0.2147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0277 0.0247
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0136 0.1522
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0594 0.0565
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0083 0.0357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.236 0.2336
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0277 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0957 0.2343
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0277 0.0247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0277 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Loa Loa (eye worm) RecQ helicase 0.0023 0.0164 0.0134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0136 0.0136
Plasmodium vivax glutathione reductase, putative 0.005 0.0594 0.5994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.058 0.0551
Brugia malayi Bromodomain containing protein 0.0041 0.0445 0.0435
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0057 0.0026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0305 0.0275
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0957 0.0948
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0031 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0432 0.1058
Onchocerca volvulus 0.0059 0.0723 0.187
Echinococcus multilocularis zinc finger protein 0.0021 0.0135 0.0105
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0588 0.0558
Brugia malayi Thioredoxin reductase 0.005 0.0594 0.0584
Schistosoma mansoni inositol monophosphatase 0.004 0.0432 0.0402
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0432 0.1058
Trypanosoma brucei ISWI complex protein 0.0016 0.0065 0.0065
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0057 0.0026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0957 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0957 0.2343
Trypanosoma brucei trypanothione reductase 0.005 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0026
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0277 0.0247
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0083 0.0083
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0657 1 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0065 0.0065
Brugia malayi glutathione reductase 0.005 0.0594 0.0584
Schistosoma mansoni zinc finger protein 0.0016 0.0065 0.0034
Toxoplasma gondii fructose-bisphospatase II 0.0657 1 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0957 0.0914
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1795 0.243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0277 0.0266
Leishmania major hypothetical protein, conserved 0.0074 0.0957 0.0957
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0277 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0957 0.2343
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0136 0.0105
Leishmania major 0.0657 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2766 0.6772
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0432 0.3996
Schistosoma mansoni hypothetical protein 0.0022 0.0153 0.0122
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0184 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0277 0.0247
Schistosoma mansoni hypothetical protein 0.0134 0.1895 0.187
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0277 0.0266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Brugia malayi beta-lactamase 0.0074 0.0957 0.0948
Plasmodium falciparum glutathione reductase 0.005 0.0594 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0957 0.0929
Brugia malayi nuclear receptor RXR 0.0014 0.0031 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0277 0.0247
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0136 0.0136
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0031 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0221
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0251 0.0221
Schistosoma mansoni hypothetical protein 0.0369 0.5538 0.5524
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.095 0.094
Schistosoma mansoni ap endonuclease 0.0021 0.0136 0.0105
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.095 0.095
Loa Loa (eye worm) glutathione reductase 0.005 0.0594 0.0565
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.058 0.0551
Echinococcus granulosus intermediate filament protein 0.0059 0.0723 0.0694
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0723 0.0694
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.058 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0277 0.0266
Brugia malayi nuclear hormone receptor 0.003 0.0277 0.0266
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0153 0.0122
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0136 0.0125
Brugia malayi ecdysteroid receptor 0.003 0.0277 0.0266
Brugia malayi intermediate filament protein 0.0059 0.0723 0.0713
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0432 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0251 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Brugia malayi nuclear receptor NHR-67 0.0014 0.0031 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0799 0.0771
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.095 0.095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0657 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Brugia malayi PHD-finger family protein 0.0027 0.0224 0.0213
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0057 0.0026
Mycobacterium tuberculosis Probable reductase 0.0115 0.1596 0.2147
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.7132 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0723 0.0694
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0184 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0957 0.0957
Loa Loa (eye worm) beta-lactamase 0.0074 0.0957 0.0929
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0277 0.0664
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0136 1
Trichomonas vaginalis esterase, putative 0.0074 0.0957 0.2343
Schistosoma mansoni coup transcription factor 0.003 0.0277 0.0247
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0026
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0432 0.4549
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0083 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0277 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.058 0.0551
Loa Loa (eye worm) hypothetical protein 0.005 0.0588 0.0558
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1596 0.8606
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0432 0.0402
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0432 0.0387
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.2615 0.6985
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0277 0.0247
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0277 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0277 0.0247
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0083
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0094 0.0063
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0031 0.002
Onchocerca volvulus 0.003 0.0277 0.0664
Brugia malayi Pre-SET motif family protein 0.0032 0.0305 0.0295
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0083 0.0083
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0957 0.1241
Onchocerca volvulus 0.0253 0.3731 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0184 0.0154
Loa Loa (eye worm) hypothetical protein 0.0058 0.0706 0.0677
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0277 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0277 0.0247
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0083 0.0357
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0277 0.0247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0136 0.0136
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.4085 0.4067
Echinococcus multilocularis lamin dm0 0.0059 0.0723 0.0694
Brugia malayi conserved hypotetical protein 0.0014 0.0031 0.002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0083 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0277 0.0266
Trypanosoma cruzi ISWI complex protein 0.0016 0.0065 0.0065
Brugia malayi beta-lactamase family protein 0.0074 0.0957 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0957 0.0957
Toxoplasma gondii exonuclease III APE 0.0021 0.0136 0.0089
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0287 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0277 0.0247
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0244 0.36 0.357
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0136 0.0105
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0277 0.0247
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3731 0.9134
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0957 0.1241
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0305 0.0275
Echinococcus multilocularis geminin 0.0369 0.5538 0.5524
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.095 0.0922
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0432 0.0432
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0031 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0277 0.0247
Leishmania major hypothetical protein, conserved 0.0016 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0046 0.0517 0.0488
Plasmodium falciparum thioredoxin reductase 0.005 0.0594 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0957 0.0957
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0957 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0164 0.0403
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0957 0.1241
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.095 0.095
Brugia malayi steroid hormone receptor 0.003 0.0277 0.0266
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.095 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.009 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0057 0.0047
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0164 0.0134
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0432 0.1058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0277 0.0266
Brugia malayi tailless protein 0.0014 0.0031 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0957 0.1241
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0136 0.0105
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0136 0.0332
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0083 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0277 0.0266
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0052
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2615 0.6403
Schistosoma mansoni ap endonuclease 0.0021 0.0136 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0235 0.0204
Brugia malayi hypothetical protein 0.0016 0.0057 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0277 0.0266
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0277 0.0266
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0657 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0277 0.0247
Leishmania major trypanothione reductase 0.005 0.0594 0.0594
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0083 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.3255 0.3235
Toxoplasma gondii thioredoxin reductase 0.005 0.0594 0.0549
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0957 0.1241
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0277 0.0247
Toxoplasma gondii fructose-bisphospatase I 0.0244 0.36 0.357
Schistosoma mansoni hypothetical protein 0.0369 0.5538 0.5524
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1596 0.2147
Brugia malayi beta-lactamase family protein 0.0074 0.0957 0.0948
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0136 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0052
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0657 1 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0957 0.1241
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0031 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0083 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0957 0.0929
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0957 0.2343
Brugia malayi nuclear receptor RXR 0.0016 0.0057 0.0047
Echinococcus granulosus zinc finger protein 0.0021 0.0135 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0277 0.0247
Onchocerca volvulus 0.0074 0.0957 0.2503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.058 0.0551
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0594 0.5994
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0164 0.0403
Mycobacterium tuberculosis Conserved protein 0.0074 0.0957 0.1241
Schistosoma mansoni inositol monophosphatase 0.004 0.0432 0.0402
Echinococcus granulosus lamin dm0 0.0059 0.0723 0.0694
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0104 0.0073
Echinococcus granulosus geminin 0.0369 0.5538 0.5524
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.095 0.0922
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0588 0.0558
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0957 0.2343
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0277 0.0664
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0657 1 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0957 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0136 0.1429
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0594 0.0594
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0305 0.0259
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1795 0.243
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.095 0.0922
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0026
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.03 0.027
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0594 0.0565
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0083 0.0035
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0134 0.1895 0.187
Loa Loa (eye worm) hypothetical protein 0.0075 0.0982 0.0954
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0657 1 1
Onchocerca volvulus 0.0032 0.0305 0.0742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0277 0.0247
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0277 0.0247
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0367 0.0404
Onchocerca volvulus 0.0059 0.0723 0.187
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0244 0.36 0.36
Schistosoma mansoni thyroid hormone receptor 0.0164 0.236 0.2336
Brugia malayi Cytochrome P450 family protein 0.0023 0.0169 0.0158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0406 0.0376
Loa Loa (eye worm) hypothetical protein 0.0074 0.0957 0.0929
Brugia malayi hypothetical protein 0.0014 0.0031 0.002
Brugia malayi nuclear receptor NHR-88 0.0014 0.0031 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0277 0.0266
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0277 0.0247
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0277 0.0266
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0244 0.36 0.36
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.095 0.095
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0083 0.0202
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1596 0.2147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1795 0.243
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0057 0.0026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.058 0.057
Echinococcus granulosus bloom syndrome protein 0.0023 0.0164 0.0134
Loa Loa (eye worm) inositol-1 0.004 0.0432 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0247
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0957 0.0929
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.3724 0.3705
Onchocerca volvulus 0.0074 0.0957 0.2503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0277 0.0247
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0136 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0277 0.0247
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0244 0.36 0.36
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0657 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.4085 1
Brugia malayi ecdysone receptor 0.0014 0.0031 0.002
Mycobacterium ulcerans hypothetical protein 0.0074 0.0957 1
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.03 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0485 0.0456

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.2 ug ml-1 Antifungal activity against Trichophyton mentagrophytes. ChEMBL. 3510297
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Epidermophyton floccosum. ChEMBL. 3510297
MIC (functional) = 50 ug ml-1 Antifungal activity against Microsporum canis ChEMBL. 3510297
MIC (functional) > 100 ug ml-1 Antifungal activity measured against Aspergillus fumigatus ChEMBL. 3510297
MIC (functional) = 100 ug ml-1 Antifungal activity measured against Sporothrix schenck ii. ChEMBL. 3510297
MIC (functional) > 100 ug ml-1 Antifungal activity against Candida parapsilosis. ChEMBL. 3510297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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