Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0139 | 0.0589 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0336 | 0.8913 | 0.8666 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0196 | 0.3019 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0196 | 0.3019 | 0.1439 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0336 | 0.8913 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0362 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0336 | 0.8913 | 0.8666 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0139 | 0.0589 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0139 | 0.0589 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0336 | 0.8913 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0336 | 0.8913 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0139 | 0.0589 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0139 | 0.0589 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0193 | 0.2878 | 0.1266 |
Leishmania major | 0.0336 | 0.8913 | 0.5 | |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0336 | 0.8913 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0139 | 0.0589 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0336 | 0.8913 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0336 | 0.8913 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0336 | 0.8913 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reversal (functional) | = 13 % | Reversal of electroconvulsive shock induced amnesia in mice following 1 mg/Kg p.o. | ChEMBL. | 3820221 |
Reversal (functional) | = 13 % | Reversal of electroconvulsive shock induced amnesia in mice following 1 mg/Kg p.o. | ChEMBL. | 3820221 |
Reversal (functional) | = 16 % | Reversal of electroconvulsive shock induced amnesia in mice following 100 mg/Kg p.o. | ChEMBL. | 3820221 |
Reversal (functional) | = 16 % | Reversal of electroconvulsive shock induced amnesia in mice following 100 mg/Kg p.o. | ChEMBL. | 3820221 |
Reversal (functional) | = 60 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, at a dose of 10 mg/Kg administered perorally | ChEMBL. | 3820221 |
Reversal (functional) | = 60 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, at a dose of 10 mg/Kg administered perorally | ChEMBL. | 3820221 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.