Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1723 | 0.9139 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Echinococcus multilocularis | geminin | 0.035 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0157 | 0.4264 | 0.5335 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1723 | 0.9139 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.6816 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.5363 | 0.6736 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0202 | 0.0122 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0752 | 0.0996 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0076 | 0.1877 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Schistosoma mansoni | synaptojanin | 0.0015 | 0.0081 | 0.0081 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0022 | 0.0273 | 0.0194 |
Onchocerca volvulus | 0.0038 | 0.0752 | 0.1345 | |
Schistosoma mansoni | cpg binding protein | 0.0093 | 0.2379 | 0.2379 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.347 | 0.347 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0343 | 0.1057 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0162 | 0.0104 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0343 | 0.1057 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0335 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.5363 | 0.6736 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0076 | 0.1877 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.347 | 0.3417 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0752 | 0.3438 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0035 | 0.0662 | 0.2916 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Brugia malayi | RNA binding protein | 0.013 | 0.347 | 0.4322 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0016 | 0.011 | 0.0163 |
Toxoplasma gondii | exonuclease III APE | 0.0076 | 0.1877 | 0.401 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0407 | 0.0416 |
Giardia lamblia | GTOR | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2797 | 0.3463 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1723 | 0.9139 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0076 | 0.1877 | 0.2667 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.3651 | 0.3651 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0752 | 0.0996 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Echinococcus granulosus | serine protein kinase ATM | 0.0027 | 0.0417 | 0.0339 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0202 | 0.0155 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0202 | 0.0122 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0752 | 0.0856 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.1094 | 0.1021 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0076 | 0.1877 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.1723 | 0.1723 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0019 | 0.0202 | 0.0675 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1094 | 0.1094 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0407 | 0.1817 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0407 | 0.1817 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.028 | 0.7923 | 1 |
Schistosoma mansoni | nocturnin | 0.0015 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0752 | 0.0856 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0027 | 0.0422 | 0.0435 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0015 | 0.0081 | 0.0081 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0184 | 0.507 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1043 | 0.1043 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Schistosoma mansoni | ap endonuclease | 0.0076 | 0.1877 | 0.1877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1043 | 0.1043 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0752 | 0.3438 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1723 | 0.1723 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0343 | 0.0335 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.3651 | 0.3651 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0035 | 0.0662 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0167 | 0.4561 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0343 | 0.1461 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0076 | 0.1877 | 1 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0019 | 0.0203 | 0.0681 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.347 | 0.4322 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0133 | 0.0077 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.347 | 0.347 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0019 | 0.0202 | 0.0675 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.1094 | 0.1292 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0019 | 0.0202 | 0.0271 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0076 | 0.1877 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0076 | 0.1877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0162 | 0.0104 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0662 | 0.0662 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0027 | 0.0417 | 0.0417 |
Schistosoma mansoni | hypothetical protein | 0.035 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0343 | 0.1057 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.3352 | 0.3352 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0752 | 0.0996 |
Echinococcus granulosus | ferritin | 0.0035 | 0.0662 | 0.0586 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0133 | 0.0077 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0417 | 0.1872 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1043 | 0.1227 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0076 | 0.1877 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1723 | 0.9139 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0081 | 0.0081 |
Trichomonas vaginalis | ferritin, putative | 0.0035 | 0.0662 | 0.0741 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0752 | 0.3735 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0752 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.3651 | 0.3599 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0131 | 0.0063 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0407 | 0.1817 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0162 | 0.0104 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0752 | 0.0752 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0752 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0162 | 0.0104 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Onchocerca volvulus | 0.0038 | 0.0752 | 0.1345 | |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.347 | 0.347 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0015 | 0.0081 | 0.0081 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0133 | 0.0077 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.3352 | 0.3297 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0343 | 0.1461 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0752 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.1723 | 0.1655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Schistosoma mansoni | cript-related | 0.0015 | 0.0081 | 0.0081 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Schistosoma mansoni | ferritin light chain | 0.0035 | 0.0662 | 0.0662 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1043 | 0.097 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0752 | 0.0856 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0662 | 0.0662 |
Brugia malayi | CXXC zinc finger family protein | 0.0088 | 0.2231 | 0.2742 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0752 | 0.0996 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.347 | 0.347 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0407 | 0.1817 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0752 | 0.0856 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0343 | 0.0335 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.1094 | 0.1021 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1043 | 0.1227 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1723 | 0.2094 |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.1094 | 0.1021 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1043 | 0.097 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0752 | 0.0856 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.1723 | 0.1655 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0662 | 0.0586 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Trichomonas vaginalis | helicase, putative | 0.002 | 0.0217 | 0.0173 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.347 | 0.4322 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0076 | 0.1877 | 0.2291 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0752 | 0.3438 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0752 | 0.0856 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0752 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0306 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0162 | 0.0452 |
Echinococcus multilocularis | cpg binding protein | 0.0093 | 0.2379 | 0.2317 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.347 | 0.4322 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0019 | 0.0202 | 0.0202 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Onchocerca volvulus | 0.0088 | 0.2231 | 0.4309 | |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0019 | 0.0203 | 0.0681 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0202 | 0.0122 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0027 | 0.0417 | 0.1872 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0662 | 0.0662 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.2797 | 0.2797 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0202 | 0.0122 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0022 | 0.0273 | 0.0194 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0752 | 0.3735 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0022 | 0.0273 | 0.0194 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0752 | 0.0856 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0752 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1094 | 0.1094 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0157 | 0.4264 | 0.5335 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0752 | 0.3735 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0662 | 0.0586 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0076 | 0.1877 | 1 |
Toxoplasma gondii | FATC domain-containing protein | 0.0027 | 0.0417 | 0.0751 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0027 | 0.0417 | 0.1872 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0076 | 0.1877 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0088 | 0.2231 | 0.2742 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0343 | 0.1057 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0076 | 0.1877 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0162 | 0.0104 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0076 | 0.1877 | 0.1811 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0752 | 0.3438 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0035 | 0.0662 | 0.3236 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0023 | 0.0306 | 0.1255 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 0.7923 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.028 | 0.7923 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0752 | 0.0996 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1043 | 0.1043 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0407 | 0.1817 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1094 | 0.1094 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0019 | 0.0202 | 0.0675 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0019 | 0.0202 | 0.0675 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0343 | 0.1057 |
Loa Loa (eye worm) | histone methyltransferase | 0.0027 | 0.0432 | 0.0448 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0343 | 0.1057 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0343 | 0.0335 |
Leishmania major | pantothenate kinase subunit, putative | 0.0016 | 0.011 | 0.0163 |
Schistosoma mansoni | synaptojanin | 0.0015 | 0.0081 | 0.0081 |
Schistosoma mansoni | ferritin light chain | 0.0035 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0335 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0752 | 0.0996 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0752 | 0.0996 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0407 | 0.0729 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0752 | 0.0856 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0752 | 0.3438 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0076 | 0.1877 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0752 | 0.0996 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1094 | 0.1094 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.347 | 0.3417 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0019 | 0.0202 | 0.0675 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0202 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.4264 | 0.5335 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0162 | 0.0452 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0752 | 0.0752 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0343 | 0.1461 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.1094 | 0.1021 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0076 | 0.1877 | 0.2291 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1043 | 0.097 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0022 | 0.0273 | 0.0194 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0035 | 0.0662 | 0.0863 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0343 | 0.1461 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0162 | 0.0121 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0015 | 0.0081 | 0.0081 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0027 | 0.0432 | 0.0354 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0752 | 0.1498 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0019 | 0.0202 | 0.0675 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.507 | 0.6362 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0343 | 0.1461 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0343 | 0.039 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.347 | 0.347 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0035 | 0.0662 | 0.7807 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.2797 | 0.3463 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Onchocerca volvulus | 0.0038 | 0.0752 | 0.1345 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.1094 | 0.1292 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0407 | 0.1817 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0752 | 0.0996 |
Schistosoma mansoni | ap endonuclease | 0.0076 | 0.1877 | 0.1877 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0417 | 0.0429 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0187 | 0.5151 | 0.5151 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0343 | 0.1057 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0022 | 0.0273 | 0.0273 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0407 | 0.1817 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.1094 | 0.1021 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0157 | 0.4264 | 0.5335 |
Schistosoma mansoni | cpg binding protein | 0.0088 | 0.2231 | 0.2231 |
Schistosoma mansoni | cpg binding protein | 0.0093 | 0.2379 | 0.2379 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Echinococcus granulosus | cpg binding protein | 0.0093 | 0.2379 | 0.2317 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0407 | 0.0416 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.1094 | 0.1021 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0019 | 0.0202 | 0.0202 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0162 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0343 | 0.1057 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Brugia malayi | TAR-binding protein | 0.013 | 0.347 | 0.4322 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0752 | 0.0676 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.1094 | 0.1292 |
Onchocerca volvulus | 0.0024 | 0.0343 | 0.0526 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0752 | 0.0676 |
Echinococcus multilocularis | ferritin | 0.0035 | 0.0662 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0335 |
Schistosoma mansoni | apoferritin-2 | 0.0035 | 0.0662 | 0.0662 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0027 | 0.0432 | 0.0354 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0202 | 0.0155 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0027 | 0.0417 | 0.0339 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0133 | 0.0077 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0752 | 0.3735 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0217 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1094 | 0.1292 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0343 | 0.039 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0035 | 0.0662 | 0.0863 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1043 | 0.097 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0752 | 0.3735 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0343 | 0.1461 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0752 | 0.0856 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.3352 | 0.3297 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0217 | 0.0173 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.347 | 0.4322 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0752 | 0.0856 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0076 | 0.1877 | 0.1811 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0752 | 0.0996 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0027 | 0.0417 | 0.0429 |
Schistosoma mansoni | hypothetical protein | 0.035 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0076 | 0.1877 | 0.2291 |
Schistosoma mansoni | apoferritin-2 | 0.0035 | 0.0662 | 0.0662 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0076 | 0.1877 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 uM | Cytotoxicity of the compound was determined in L1210 cell lines | ChEMBL. | 14613316 |
IC50 (functional) | = 2.3 uM | Cytotoxicity of the compound was determined in DFMO treated L1210 cell lines | ChEMBL. | 14613316 |
IC50 (functional) | = 9.1 uM | Cytotoxicity of the compound was determined in CHO-MG cell lines | ChEMBL. | 14613316 |
IC50 (functional) | = 9.5 uM | Cytotoxicity of the compound was determined in CHO cell lines | ChEMBL. | 14613316 |
Ki (binding) | = 12.5 | Binding affinity of the compound towards polyamine transporter was determined in L1210 cell lines | ChEMBL. | 14613316 |
Ratio (functional) | = 0.7 | Ratio of IC50 value determined in L1210 cell lines to the IC50 value determined in DFMO treated L1210 cell lines was evaluated | ChEMBL. | 14613316 |
Ratio (functional) | = 1 | Ratio of IC50 value determined in CHO cell lines to the IC50 value determined in CHO-MG cell lines was evaluated | ChEMBL. | 14613316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.