Detailed information for compound 25486

Basic information

Technical information
  • TDR Targets ID: 25486
  • Name: (2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-y l)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo- 3,4-dihydro-1H-tetracene-2-carboxylic acid
  • MW: 529.493 | Formula: C26H27NO11
  • H donors: 6 H acceptors: 8 LogP: -1.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1cccc2c1C(=O)c1c(C2=O)c(O)c2c(c1O)[C@H](OC1CC(N)C(C(O1)C)O)C[C@@](C2)(O)C(=O)O
  • InChi: 1S/C26H27NO11/c1-9-20(28)12(27)6-15(37-9)38-14-8-26(35,25(33)34)7-11-17(14)24(32)19-18(22(11)30)21(29)10-4-3-5-13(36-2)16(10)23(19)31/h3-5,9,12,14-15,20,28,30,32,35H,6-8,27H2,1-2H3,(H,33,34)/t9?,12?,14-,15?,20?,26-/m0/s1
  • InChiKey: UOZJSBYGENSCDJ-ZXLBUDMUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,4S)-4-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxylic acid
  • (2S,4S)-4-[(4-amino-5-hydroxy-6-methyl-2-tetrahydropyranyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxylic acid
  • (2S,4S)-4-(4-azanyl-5-hydroxy-6-methyl-oxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxylic acid
  • (2S,4S)-4-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-2,5,12-trihydroxy-6,11-diketo-7-methoxy-3,4-dihydro-1H-tetracene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adenoreceptor 0.1353 0.2638 0.7605
Loa Loa (eye worm) BEN-1 protein 0.1544 0.3017 0.8559
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0145 0.0242 0.0693
Plasmodium vivax tubulin beta chain, putative 0.1544 0.3017 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0233 0.0667
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1353 0.2638 0.7605
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.0168
Schistosoma mansoni growth hormone secretagogue receptor 0.1353 0.2638 0.7605
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1353 0.2638 0.2638
Loa Loa (eye worm) brahma associated protein 0.0129 0.0211 0.0599
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0095 0.0305
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni ephrin receptor 0.0053 0.006 0.0167
Trypanosoma brucei trypanothione reductase 0.0071 0.0095 0.0305
Plasmodium falciparum plasmepsin V 0.0142 0.0236 0.0773
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1353 0.2638 0.2638
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi glutathione reductase 0.0071 0.0095 0.0095
Toxoplasma gondii melibiase subfamily protein 0.0106 0.0165 0.0535
Loa Loa (eye worm) beta-tubulin 0.1544 0.3017 0.8559
Loa Loa (eye worm) aspartyl protease 6 0.0142 0.0236 0.067
Echinococcus multilocularis neuropeptides capa receptor 0.1353 0.2638 0.469
Echinococcus granulosus tubulin beta 1 chain 0.1544 0.3017 0.5365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.015 0.015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0025 0.0003 0.091
Echinococcus multilocularis ring and YY1 binding protein 0.0046 0.0046 0.0077
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0051 0.0055 0.0094
Echinococcus multilocularis integrin alpha ps 0.0034 0.0021 0.0034
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0016 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.18 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Leishmania major hypothetical protein, conserved 0.0046 0.0046 0.0152
Brugia malayi larval opioid receptor 0.1353 0.2638 0.2638
Plasmodium vivax aspartyl protease, putative 0.0142 0.0236 0.0773
Echinococcus granulosus integrin alpha ps 0.007 0.0094 0.0164
Entamoeba histolytica tubulin family protein 0.1544 0.3017 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0233 0.0667
Echinococcus multilocularis allatostatin A receptor 0.1764 0.3453 0.6141
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Onchocerca volvulus 0.0046 0.0046 0.0133
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0046 0.0046 0.0133
Schistosoma mansoni integrin alpha 0.0157 0.0266 0.0761
Onchocerca volvulus 0.1353 0.2638 0.7639
Toxoplasma gondii beta tubulin 0.1544 0.3017 1
Schistosoma mansoni CD36-like class B scavenger receptor 0.0145 0.0242 0.0693
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0024 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0037 0.0112
Plasmodium falciparum plasmepsin I 0.0601 0.1146 0.3792
Echinococcus granulosus G protein coupled receptor 139 0.1353 0.2638 0.469
Echinococcus multilocularis CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Brugia malayi Tachykinin-like peptides receptor 99D 0.1353 0.2638 0.2638
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0016 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi hypothetical protein 0.0142 0.0236 0.0236
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0046 0.0046 0.0077
Onchocerca volvulus 0.0046 0.0046 0.0133
Brugia malayi Melibiase family protein 0.0071 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0055 0.0156
Loa Loa (eye worm) hypothetical protein 0.0071 0.0095 0.0268
Echinococcus granulosus Zinc finger RanBP2 type 0.0046 0.0046 0.0077
Echinococcus multilocularis Tubulin beta 2C chain 0.1544 0.3017 0.5365
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0071 0.0095 0.0164
Echinococcus multilocularis Tubulin beta 2C chain 0.1544 0.3017 0.5365
Onchocerca volvulus 0.0142 0.0236 0.0684
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.0601 0.1146 0.3252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1353 0.2638 0.7605
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1353 0.2638 0.7605
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0106 0.0165 0.0289
Brugia malayi Thioredoxin reductase 0.0071 0.0095 0.0095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0165 0.0468
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0046 0.0046 0.0077
Echinococcus multilocularis dro:myosuppressin receptor 0.1353 0.2638 0.469
Schistosoma mansoni CD36-like class B scavenger receptor 0.0145 0.0242 0.0693
Loa Loa (eye worm) tubulin beta-1 chain 0.1544 0.3017 0.8559
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.0003 0.0002
Loa Loa (eye worm) TK/EPH protein kinase 0.0068 0.0089 0.0252
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0046 0.0046 0.0141
Schistosoma mansoni RNA binding protein 0.0046 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Plasmodium falciparum glutathione reductase 0.0071 0.0095 0.0305
Echinococcus granulosus integrin alpha 3 0.012 0.0193 0.034
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0061
Plasmodium falciparum plasmepsin X 0.0142 0.0236 0.0773
Plasmodium falciparum plasmepsin III 0.0142 0.0236 0.0773
Loa Loa (eye worm) neuropeptide F receptor 0.1353 0.2638 0.7484
Leishmania major beta tubulin 0.1544 0.3017 1
Treponema pallidum NADH oxidase 0.0025 0.0003 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0129 0.0211 0.0689
Echinococcus multilocularis neuropeptides capa receptor 0.1353 0.2638 0.469
Schistosoma mansoni brg-1 associated factor 0.0129 0.0211 0.0602
Schistosoma mansoni neuropeptide f receptor 76f 0.1353 0.2638 0.7605
Brugia malayi YY1-associated factor 2 0.0046 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0046 0.0046 0.0141
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0051 0.0055 0.0094
Trypanosoma brucei beta tubulin 0.1544 0.3017 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0052 0.0057 0.0163
Schistosoma mansoni hypothetical protein 0.1353 0.2638 0.7605
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0165 0.0468
Echinococcus granulosus fmrfamide receptor 0.1353 0.2638 0.469
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0106 0.0165 0.0289
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0129 0.0211 0.0689
Echinococcus multilocularis lysosome membrane protein 2 0.0145 0.0242 0.0427
Giardia lamblia Beta tubulin 0.1544 0.3017 1
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni biogenic amine (5HT) receptor 0.1353 0.2638 0.7605
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus multilocularis Tubulin beta 2C chain 0.1544 0.3017 0.5365
Echinococcus multilocularis beta tubulin 0.1544 0.3017 0.5365
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Schistosoma mansoni hypothetical protein 0.1353 0.2638 0.7605
Leishmania major beta tubulin 0.1544 0.3017 1
Plasmodium vivax plasmepsin IV, putative 0.0601 0.1146 0.3792
Plasmodium falciparum plasmepsin IV 0.0601 0.1146 0.3792
Echinococcus multilocularis neuropeptide receptor A26 0.1353 0.2638 0.469
Echinococcus multilocularis neuropeptide FF receptor 2 0.1353 0.2638 0.469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Echinococcus granulosus Tubulin beta 2C chain 0.1544 0.3017 0.5365
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0601 0.1146 0.3792
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni amine GPCR 0.1353 0.2638 0.7605
Schistosoma mansoni histamine h1 receptor 0.1353 0.2638 0.7605
Leishmania major beta tubulin 0.1544 0.3017 1
Onchocerca volvulus 0.1353 0.2638 0.7639
Echinococcus multilocularis GPCR, family 2 0.0031 0.0016 0.0025
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0106 0.0165 0.0289
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1353 0.2638 0.469
Echinococcus multilocularis SWI:SNF matrix associated 0.0129 0.0211 0.0371
Onchocerca volvulus 0.1353 0.2638 0.7639
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi SWIB/MDM2 domain containing protein 0.0129 0.0211 0.0211
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1353 0.2638 0.2638
Schistosoma mansoni memapsin-2 (A01 family) 0.0142 0.0236 0.0675
Echinococcus granulosus neuropeptides capa receptor 0.1353 0.2638 0.469
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.0003 0.0002
Trypanosoma brucei unspecified product 0.0035 0.0024 0.0068
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Echinococcus granulosus sodium channel protein 0.0037 0.0027 0.0044
Brugia malayi Serotonin receptor 0.1353 0.2638 0.2638
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0142 0.0236 0.067
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Brugia malayi neuropeptide F receptor 0.1353 0.2638 0.2638
Echinococcus granulosus neuropeptide receptor 0.1353 0.2638 0.469
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0129 0.0211 0.0689
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0046 0.0046 0.0141
Plasmodium falciparum thioredoxin reductase 0.0071 0.0095 0.0305
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0046 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0129 0.0211 0.0602
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Echinococcus granulosus dna polymerase kappa 0.0042 0.0037 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni hypothetical protein 0.1353 0.2638 0.7605
Brugia malayi AKH receptor 0.1353 0.2638 0.2638
Echinococcus multilocularis SWI:SNF matrix associated 0.0129 0.0211 0.0371
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Echinococcus granulosus integrin alpha ps 0.0034 0.0021 0.0034
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0046 0.0141
Toxoplasma gondii aspartyl protease ASP1 0.0601 0.1146 0.3792
Echinococcus granulosus allatostatin A receptor 0.1764 0.3453 0.6141
Loa Loa (eye worm) TYRA-2 protein 0.1353 0.2638 0.7484
Brugia malayi Melatonin receptor type 1A 0.1353 0.2638 0.2638
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0046 0.0046 0.0141
Echinococcus granulosus thioredoxin glutathione reductase 0.0071 0.0095 0.0166
Brugia malayi Serotonin receptor 0.1353 0.2638 0.2638
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0213 0.0375
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1353 0.2638 0.7484
Trichomonas vaginalis tubulin, putative 0.1544 0.3017 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1353 0.2638 0.7605
Echinococcus granulosus CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Echinococcus granulosus tubulin subunit beta 0.1544 0.3017 0.5365
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Brugia malayi Dopamine receptor protein 2 0.1353 0.2638 0.2638
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1353 0.2638 0.7639
Onchocerca volvulus 0.1353 0.2638 0.7639
Brugia malayi beta-tubulin, identical 0.1544 0.3017 0.3017
Echinococcus multilocularis orexin receptor type 2 0.1353 0.2638 0.469
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0016 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0071 0.0095 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.019 0.0539
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni hypothetical protein 0.013 0.0213 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Echinococcus multilocularis G protein coupled receptor 139 0.1649 0.3225 0.5736
Loa Loa (eye worm) hypothetical protein 0.0087 0.0126 0.0358
Loa Loa (eye worm) tubulin beta chain 0.1544 0.3017 0.8559
Schistosoma mansoni opsin-like receptor 0.1353 0.2638 0.7605
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1353 0.2638 0.469
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0037 0.0027 0.0044
Brugia malayi Eukaryotic aspartyl protease family protein 0.0142 0.0236 0.0236
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0601 0.1146 0.2036
Echinococcus multilocularis g protein coupled receptor 0.1353 0.2638 0.469
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0085 0.0148
Echinococcus multilocularis Tubulin beta 2C chain 0.1544 0.3017 0.5365
Schistosoma mansoni neuropeptide F-like receptor 0.1353 0.2638 0.7605
Onchocerca volvulus 0.1353 0.2638 0.7639
Echinococcus granulosus hypothetical protein 0.1353 0.2638 0.469
Echinococcus multilocularis neuropeptide s receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) G-protein coupled receptor 0.1353 0.2638 0.7484
Brugia malayi hypothetical protein 0.0142 0.0236 0.0236
Schistosoma mansoni integrin alpha-ps 0.007 0.0094 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.1353 0.2638 0.7484
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.013
Brugia malayi G protein-coupled receptor F59B2.13 0.1353 0.2638 0.2638
Loa Loa (eye worm) neuropeptide F receptor 0.1353 0.2638 0.7484
Echinococcus multilocularis thioredoxin glutathione reductase 0.0071 0.0095 0.0166
Brugia malayi CD36 family protein 0.0145 0.0242 0.0242
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1353 0.2638 0.469
Trypanosoma brucei beta tubulin 0.1544 0.3017 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0037 0.0062
Brugia malayi G-protein coupled receptor 0.1353 0.2638 0.2638
Toxoplasma gondii beta-tubulin, putative 0.1544 0.3017 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0017 0.0046
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni hypothetical protein 0.1353 0.2638 0.7605
Brugia malayi ORL1-like opioid receptor 0.1353 0.2638 0.2638
Echinococcus multilocularis fmrfamide receptor 0.1353 0.2638 0.469
Echinococcus granulosus GPCR family 2 0.0031 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0046 0.0141
Onchocerca volvulus 0.1353 0.2638 0.7639
Brugia malayi G protein-coupled receptor 0.1353 0.2638 0.2638
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0037 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1353 0.2638 0.2638
Plasmodium falciparum plasmepsin VII 0.0142 0.0236 0.0773
Echinococcus granulosus CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0129 0.0211 0.0689
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1353 0.2638 0.7605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0041
Schistosoma mansoni amine GPCR 0.1353 0.2638 0.7605
Brugia malayi G-protein coupled receptor 0.1353 0.2638 0.2638
Schistosoma mansoni amine GPCR 0.1353 0.2638 0.7605
Loa Loa (eye worm) guanylate kinase 0.0024 0.0002 0.0006
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1353 0.2638 0.469
Plasmodium falciparum plasmepsin VI 0.0601 0.1146 0.3792
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Echinococcus multilocularis g protein coupled receptor 0.1353 0.2638 0.469
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0046 0.0046 0.0077
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0037 0.0112
Echinococcus multilocularis G-protein coupled receptor, putative 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0046
Echinococcus granulosus zinc finger protein Ran binding 0.0046 0.0046 0.0077
Echinococcus granulosus beta tubulin 0.1544 0.3017 0.5365
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1353 0.2638 0.7605
Brugia malayi Guanylate kinase family protein 0.0024 0.0002 0.0002
Brugia malayi Tubulin beta-1 chain 0.1544 0.3017 0.3017
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0003 0.0033
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1353 0.2638 0.469
Schistosoma mansoni cathepsin D (A01 family) 0.1771 0.3468 1
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0051 0.0055 0.0153
Schistosoma mansoni fusion 0.0046 0.0046 0.0126
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1353 0.2638 0.7605
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.0142 0.0236 0.067
Onchocerca volvulus 0.1353 0.2638 0.7639
Trypanosoma brucei beta tubulin 0.1544 0.3017 1
Schistosoma mansoni integrin alpha-ps 0.0037 0.0027 0.0072
Echinococcus multilocularis integrin alpha ps 0.007 0.0094 0.0164
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Plasmodium vivax aspartyl proteinase, putative 0.0601 0.1146 0.3792
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1353 0.2638 0.7484
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.015 0.0425
Onchocerca volvulus 0.1353 0.2638 0.7639
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0025 0.0003 1
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus granulosus neuropeptide s receptor 0.1353 0.2638 0.469
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0016 0.0025
Trypanosoma cruzi beta tubulin, putative 0.1544 0.3017 1
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0211 0.0689
Echinococcus granulosus sex peptide receptor 0.1353 0.2638 0.469
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus granulosus g-protein coupled receptor 0.1353 0.2638 0.469
Echinococcus granulosus ring and YY1 binding protein 0.0046 0.0046 0.0077
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0145 0.0242 0.0702
Echinococcus granulosus neuropeptide Y receptor 0.1353 0.2638 0.469
Schistosoma mansoni cd36 antigen 0.0145 0.0242 0.0693
Toxoplasma gondii beta-1 tubulin, putative 0.1544 0.3017 1
Echinococcus granulosus tm gpcr rhodopsin 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.013
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0046 0.0046 0.0141
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0025 0.0003 0.091
Brugia malayi putative neuropeptide receptor NPR1 0.1353 0.2638 0.2638
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.0067 0.0088 0.025
Toxoplasma gondii aspartyl protease ASP3 0.0142 0.0236 0.0773
Brugia malayi putative neuropeptide receptor 0.1353 0.2638 0.2638
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0051 0.0055 0.0094
Echinococcus granulosus neuropeptide receptor A26 0.1353 0.2638 0.469
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1353 0.2638 0.469
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0046 0.0046 0.0046
Brugia malayi Pepsin A precursor 0.0142 0.0236 0.0236
Trichomonas vaginalis tubulin gamma chain, putative 0.1544 0.3017 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1353 0.2638 0.469
Trypanosoma brucei beta tubulin 0.1544 0.3017 1
Schistosoma mansoni amine GPCR 0.1353 0.2638 0.7605
Onchocerca volvulus 0.0053 0.0059 0.0171
Echinococcus multilocularis CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Echinococcus multilocularis fmrfamide receptor 0.1353 0.2638 0.469
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0016 0.0016
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0025 0.0003 0.0033
Schistosoma mansoni neuropeptide receptor 0.1353 0.2638 0.7605
Plasmodium vivax aspartyl protease, putative 0.0142 0.0236 0.0773
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0046 0.0046 0.0046
Echinococcus multilocularis neuropeptide receptor 0.1353 0.2638 0.469
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0037 1
Brugia malayi brahma associated protein 60 kDa 0.0129 0.0211 0.0211
Leishmania major beta tubulin 0.1544 0.3017 1
Onchocerca volvulus 0.1353 0.2638 0.7639
Onchocerca volvulus 0.1353 0.2638 0.7639
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1353 0.2638 0.7605
Echinococcus multilocularis tubulin subunit beta 0.1544 0.3017 0.5365
Loa Loa (eye worm) tubulin beta-4 chain 0.1544 0.3017 0.8559
Echinococcus granulosus CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0213 0.0375
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Echinococcus granulosus serotonin receptor 0.1353 0.2638 0.469
Echinococcus multilocularis tubulin beta 1 chain 0.1544 0.3017 0.5365
Schistosoma mansoni myosin xvIII 0.1353 0.2638 0.7605
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0022
Leishmania major beta tubulin 0.1544 0.3017 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0025 0.0003 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0601 0.1146 0.3301
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus multilocularis zinc finger protein Ran binding 0.0046 0.0046 0.0077
Schistosoma mansoni hypothetical protein 0.0034 0.0021 0.0055
Plasmodium falciparum plasmepsin VIII, putative 0.0142 0.0236 0.0773
Echinococcus granulosus peptide allatostatin:somatostatin 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.013
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Trichomonas vaginalis tubulin epsilon chain, putative 0.1544 0.3017 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0046 0.0046 0.0141
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0601 0.1146 0.3792
Leishmania major beta tubulin 0.1544 0.3017 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1353 0.2638 0.7605
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Onchocerca volvulus 0.1353 0.2638 0.7639
Loa Loa (eye worm) hypothetical protein 0.0098 0.015 0.0425
Echinococcus granulosus biogenic amine 5HT receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0095 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.015 0.015
Echinococcus granulosus neuropeptide receptor 0.1649 0.3225 0.5736
Schistosoma mansoni biogenic amine receptor 0.1353 0.2638 0.7605
Schistosoma mansoni biogenic amine receptor 0.1353 0.2638 0.7605
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0003 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0025 0.0003 0.091
Echinococcus granulosus tm gpcr rhodopsin 0.1353 0.2638 0.469
Echinococcus granulosus SWI:SNF matrix associated 0.0129 0.0211 0.0371
Onchocerca volvulus 0.1353 0.2638 0.7639
Leishmania major beta tubulin 0.1544 0.3017 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0142 0.0236 0.0236
Onchocerca volvulus 0.1353 0.2638 0.7639
Brugia malayi ephrin receptor 1 precursor 0.0025 0.0005 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0025 0.0003 0.0003
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0129 0.0211 0.0371
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1764 0.3453 0.9958
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0024 0.0002 0.0006
Echinococcus granulosus dro:myosuppressin receptor 0.1353 0.2638 0.469
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus granulosus beta tubulin 0.1544 0.3017 0.5365
Echinococcus multilocularis g-protein coupled receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus granulosus g protein coupled receptor 0.1353 0.2638 0.469
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1353 0.2638 0.7605
Echinococcus multilocularis sex peptide receptor 0.1353 0.2638 0.469
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1353 0.2638 0.7605
Brugia malayi neuropeptide F receptor 0.1353 0.2638 0.2638
Echinococcus multilocularis neuropeptide Y receptor 0.1353 0.2638 0.469
Echinococcus granulosus neuropeptide FF receptor 2 0.1353 0.2638 0.469
Schistosoma mansoni opsin-like receptor 0.1353 0.2638 0.7605
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2857 0.5621 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1353 0.2638 0.469
Schistosoma mansoni TRABID protein (C64 family) 0.0046 0.0046 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Plasmodium vivax plasmepsin V, putative 0.0142 0.0236 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Schistosoma mansoni biogenic amine receptor 0.1353 0.2638 0.7605
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0025 0.0003 0.0011
Schistosoma mansoni amine GPCR 0.1353 0.2638 0.7605
Plasmodium vivax glutathione reductase, putative 0.0071 0.0095 0.0305
Chlamydia trachomatis DNA topoisomerase I 0.0129 0.0211 1
Leishmania major beta tubulin 0.1544 0.3017 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1353 0.2638 0.7639
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0003 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0025 0.0003 0.0033
Brugia malayi Dopamine receptor 0.1353 0.2638 0.2638
Plasmodium falciparum plasmepsin II 0.0601 0.1146 0.3792
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1353 0.2638 0.7484
Echinococcus multilocularis sodium channel protein 0.0037 0.0027 0.0044
Echinococcus multilocularis SWI:SNF matrix associated 0.0129 0.0211 0.0371
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1353 0.2638 0.7605
Brugia malayi hypothetical protein 0.0145 0.0242 0.0242
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Plasmodium falciparum plasmepsin IX 0.0142 0.0236 0.0773
Onchocerca volvulus 0.1353 0.2638 0.7639
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1353 0.2638 0.469
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1353 0.2638 0.469
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1353 0.2638 0.469
Leishmania major beta tubulin 0.1544 0.3017 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Loa Loa (eye worm) thioredoxin reductase 0.0071 0.0095 0.0271
Toxoplasma gondii thioredoxin reductase 0.0071 0.0095 0.0305
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Leishmania major hypothetical protein, conserved 0.0046 0.0046 0.0152
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0095 0.0267
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1544 0.3017 0.5365
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Plasmodium vivax aspartyl protease, putative 0.0142 0.0236 0.0773
Brugia malayi aspartic protease BmAsp-2, identical 0.0142 0.0236 0.0236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0016 0.0025
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Plasmodium vivax thioredoxin reductase, putative 0.0071 0.0095 0.0305
Loa Loa (eye worm) glutathione reductase 0.0071 0.0095 0.0271
Loa Loa (eye worm) melatonin receptor type 1A 0.1353 0.2638 0.7484
Brugia malayi follicle stimulating hormone receptor 0.18 0.3525 0.3525
Echinococcus multilocularis integrin alpha ps 0.007 0.0094 0.0164
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Schistosoma mansoni zinc finger protein 0.0046 0.0046 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0233 0.0411
Brugia malayi RE15519p 0.1353 0.2638 0.2638
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0049
Schistosoma mansoni neuropeptide receptor 0.1353 0.2638 0.7605
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Onchocerca volvulus 0.1353 0.2638 0.7639
Trichomonas vaginalis tubulin epsilon chain, putative 0.1544 0.3017 1
Leishmania major beta tubulin 0.1544 0.3017 1
Schistosoma mansoni neuropeptide F-like receptor 0.1353 0.2638 0.7605
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.0003 0.0003
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0129 0.0211 0.0371
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.0123 0.0199 0.0565
Brugia malayi Guanylate kinase family protein 0.0024 0.0002 0.0002
Echinococcus granulosus Tubulin beta 2C chain 0.1544 0.3017 0.5365
Schistosoma mansoni hypothetical protein 0.0067 0.0088 0.0248
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Leishmania major trypanothione reductase 0.0071 0.0095 0.0316
Trichomonas vaginalis tubulin beta chain, putative 0.1544 0.3017 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus multilocularis integrin alpha 3 0.012 0.0193 0.034
Loa Loa (eye worm) hypothetical protein 0.1764 0.3453 0.9797
Echinococcus multilocularis neuropeptide receptor 0.1649 0.3225 0.5736
Echinococcus granulosus rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus granulosus g protein coupled receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) BEN-1 protein 0.1544 0.3017 0.8559
Schistosoma mansoni cathepsin D (A01 family) 0.1771 0.3468 1
Echinococcus granulosus Tubulin beta 2C chain 0.1544 0.3017 0.5365
Schistosoma mansoni opsin-like receptor 0.1353 0.2638 0.7605
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0046 0.0046 0.0141
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0129 0.0211 0.0689
Trichomonas vaginalis tubulin alpha chain, putative 0.1544 0.3017 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0051 0.0055 0.0094
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0041
Schistosoma mansoni neuropeptide receptor 0.1353 0.2638 0.7605
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1353 0.2638 0.469
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0037 0.0112
Brugia malayi Dopamine receptor protein 1 0.1353 0.2638 0.2638
Echinococcus granulosus neuropeptides capa receptor 0.1353 0.2638 0.469
Schistosoma mansoni hypothetical protein 0.0129 0.0211 0.0602
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1353 0.2638 0.469
Leishmania major beta tubulin 0.1544 0.3017 1
Brugia malayi Peripheral plasma membrane protein CASK 0.0024 0.0002 0.0002
Echinococcus granulosus somatostatin receptor 0.1353 0.2638 0.469
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0119 0.019 0.019
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0129 0.0211 0.0599
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1353 0.2638 0.469
Echinococcus multilocularis serotonin receptor 0.1353 0.2638 0.469
Echinococcus granulosus 7TM GPCR rhodopsin 0.1353 0.2638 0.469
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Echinococcus multilocularis CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Giardia lamblia Beta tubulin 0.1544 0.3017 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0142 0.0236 0.0773
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.013
Onchocerca volvulus 0.1764 0.3453 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Echinococcus granulosus tubulin beta 4A class IVa 0.1544 0.3017 0.5365
Trypanosoma cruzi WLM domain containing protein, putative 0.0046 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Plasmodium falciparum tubulin beta chain 0.1544 0.3017 1
Plasmodium vivax aspartyl proteinase, putative 0.0142 0.0236 0.0773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Schistosoma mansoni hypothetical protein 0.0046 0.0046 0.0126
Brugia malayi Integrin alpha pat-2 precursor 0.0157 0.0266 0.0266
Onchocerca volvulus 0.0046 0.0046 0.0133
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0046 0.0046 0.0141
Onchocerca volvulus 0.0142 0.0236 0.0684
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1353 0.2638 0.2638
Toxoplasma gondii aspartyl protease 0.0142 0.0236 0.0773
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0046 0.0046 0.0141
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0037 0.0027 0.009
Echinococcus multilocularis serotonin receptor 0.1353 0.2638 0.469
Echinococcus granulosus CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus granulosus Tubulin beta 2C chain 0.1544 0.3017 0.5365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Brugia malayi hypothetical protein 0.1559 0.3046 0.3046
Brugia malayi hypothetical protein 0.0145 0.0242 0.0242
Leishmania major beta tubulin 0.1544 0.3017 1
Loa Loa (eye worm) integrin alpha pat-2 0.0242 0.0434 0.1233
Leishmania major hypothetical protein, conserved 0.0046 0.0046 0.0152
Echinococcus granulosus CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0165 0.0468
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0017 0.0046
Leishmania major hypothetical protein, conserved 0.0046 0.0046 0.0152
Schistosoma mansoni hypothetical protein 0.0129 0.0211 0.0602
Brugia malayi brahma associated protein 60 kDa 0.0129 0.0211 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.2857 0.5621 1
Echinococcus multilocularis 0.0071 0.0095 0.0164
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus granulosus neuropeptide Y receptor 0.1353 0.2638 0.469
Toxoplasma gondii ran binding protein 0.0046 0.0046 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1353 0.2638 0.7605
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0601 0.1146 0.2036
Loa Loa (eye worm) hypothetical protein 0.0142 0.0236 0.067
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1353 0.2638 0.469
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0085 0.0148
Echinococcus granulosus lysosome membrane protein 2 0.0145 0.0242 0.0427
Schistosoma mansoni hypothetical protein 0.031 0.0569 0.1636
Echinococcus multilocularis beta tubulin 0.1544 0.3017 0.5365
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0077
Brugia malayi hypothetical protein 0.1353 0.2638 0.2638
Echinococcus multilocularis Tubulin beta 2C chain 0.1544 0.3017 0.5365
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1353 0.2638 0.7484
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0016 0.0025
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0071 0.0095 0.0942
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0088 0.0088
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0046 0.0046 0.0046
Echinococcus granulosus 7tm_1 domain containing protein 0.1353 0.2638 0.469
Echinococcus granulosus alpha 1A adrenergic receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus multilocularis CD36 class B scavenger receptor 0.0145 0.0242 0.0427
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1353 0.2638 0.469
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0165 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Echinococcus granulosus orexin receptor type 2 0.1353 0.2638 0.469
Leishmania major hypothetical protein, conserved 0.0046 0.0046 0.0152
Entamoeba histolytica tubulin family protein 0.1544 0.3017 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0601 0.1146 0.3252
Loa Loa (eye worm) tubulin beta-2A chain 0.1544 0.3017 0.8559
Schistosoma mansoni tubulin subunit beta 0.1544 0.3017 0.8699
Onchocerca volvulus 0.0046 0.0046 0.0133
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0051 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0071 0.0095 0.0267
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0037 0.0112
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Echinococcus granulosus Tubulin beta 2C chain 0.1544 0.3017 0.5365
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.1559 0.3046 0.8643
Brugia malayi PDZ domain containing protein 0.0052 0.0057 0.0057
Brugia malayi polk-prov protein 0.0032 0.0017 0.0017
Onchocerca volvulus 0.0129 0.0211 0.0611
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Echinococcus multilocularis somatostatin receptor 0.1353 0.2638 0.469
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0041
Echinococcus granulosus g protein coupled receptor 0.1353 0.2638 0.469
Giardia lamblia Beta tubulin 0.1544 0.3017 1
Schistosoma mansoni neuropeptide receptor 0.1649 0.3225 0.9301
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0046 0.0141
Brugia malayi sulfakinin receptor protein 0.1559 0.3046 0.3046
Echinococcus granulosus biogenic amine 5HT receptor 0.1353 0.2638 0.469
Mycobacterium tuberculosis Possible exported protein 0.0534 0.1013 1
Chlamydia trachomatis SWIB complex protein 0.0129 0.0211 1
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0211 0.0689
Loa Loa (eye worm) hypothetical protein 0.1353 0.2638 0.7484
Loa Loa (eye worm) hypothetical protein 0.0024 0.0002 0.0006
Echinococcus multilocularis g protein coupled receptor 0.1353 0.2638 0.469
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.013
Onchocerca volvulus 0.1353 0.2638 0.7639
Loa Loa (eye worm) hypothetical protein 0.0145 0.0242 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0037 0.0112
Trypanosoma cruzi WLM domain containing protein, putative 0.0046 0.0046 0.0141
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1353 0.2638 0.7605
Echinococcus multilocularis rhodopsin orphan GPCR 0.1353 0.2638 0.469
Trypanosoma brucei RNA helicase, putative 0.031 0.0569 0.1878
Schistosoma mansoni alpha-1 adrenergic receptor 0.1353 0.2638 0.7605
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0025 0.0003 0.0033
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0142 0.0236 0.0675
Onchocerca volvulus 0.0024 0.0002 0.0007
Leishmania major beta tubulin 0.1544 0.3017 1
Echinococcus multilocularis neuropeptide Y receptor 0.1353 0.2638 0.469

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.007 uM In vitro cytotoxic activity against human breast cancer cell line MD-MB-468 after 72 h of drug exposure determined by the SRB assay ChEMBL. 14980672
IC50 (functional) = 0.007 uM In vitro cytotoxic activity against human breast cancer cell line T-47D after 72 h of drug exposure determined by the SRB assay ChEMBL. 14980672
IC50 (functional) = 0.02 uM In vitro cytotoxic activity against human ovarian carcinoma cell line SK-OV-3 after 72 h of drug exposure determined by the SRB assay ChEMBL. 14980672
IC50 (functional) = 0.025 uM In vitro cytotoxic activity against human colon cancer cell line HCT15 after 72 h of drug exposure determined by the SRB assay ChEMBL. 14980672

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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