Detailed information for compound 254861

Basic information

Technical information
  • TDR Targets ID: 254861
  • Name: 1-hydroxy-1-(7-phenoxy-2,3-dihydro-1H-inden-1 -yl)urea
  • MW: 284.31 | Formula: C16H16N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)N(C1CCc2c1c(ccc2)Oc1ccccc1)O
  • InChi: 1S/C16H16N2O3/c17-16(19)18(20)13-10-9-11-5-4-8-14(15(11)13)21-12-6-2-1-3-7-12/h1-8,13,20H,9-10H2,(H2,17,19)
  • InChiKey: GGKNWMLKBDFJRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-hydroxy-1-(7-phenoxyindan-1-yl)urea
  • 1-hydroxy-1-(7-phenoxy-1-indanyl)urea
  • 1-hydroxy-1-[7-(phenoxy)-2,3-dihydro-1H-inden-1-yl]urea
  • 1-hydroxy-1-[7-(phenoxy)indan-1-yl]urea
  • 1-hydroxy-1-[7-(phenoxy)-1-indanyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0081 0.0079
Onchocerca volvulus 0.0035 0.0837 0.1397
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0548 0.0545
Loa Loa (eye worm) hypothetical protein 0.0026 0.0548 0.1047
Brugia malayi serine/threonine-protein kinase plk-2 0.0077 0.2145 0.4119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Entamoeba histolytica alcohol dehydrogenase, putative 0.0046 0.1182 0.2455
Loa Loa (eye worm) oxidoreductase 0.0159 0.4691 0.9007
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0081 0.0151
Toxoplasma gondii aldo-keto reductase 0.0046 0.1182 0.2455
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0005 0.0009
Echinococcus multilocularis aldehyde reductase 0.0113 0.326 0.3259
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0489 0.0487
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0128 0.0148
Schistosoma mansoni hypothetical protein 0.001 0.0047 0.0042
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0489 0.0487
Onchocerca volvulus 0.0009 0.004 0.006
Echinococcus granulosus cpg binding protein 0.0025 0.0512 0.0509
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0741 0.1237
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0548 0.0545
Schistosoma mansoni aldehyde dehydrogenase 0.01 0.286 0.2857
Brugia malayi hypothetical protein 0.0024 0.0489 0.094
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.4691 0.7857
Loa Loa (eye worm) hypothetical protein 0.0159 0.4691 0.9007
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Mycobacterium leprae Conserved hypothetical protein 0.0113 0.326 0.5922
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0741 0.1184
Schistosoma mansoni cpg binding protein 0.0025 0.0512 0.0508
Trypanosoma cruzi polo-like protein kinase, putative 0.0077 0.2145 0.4052
Plasmodium vivax SET domain protein, putative 0.0026 0.0548 0.4441
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0005 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0005 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0548 0.0543
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Schistosoma mansoni rab6-interacting 0.0024 0.0489 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0128 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0005 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.1182 0.1929
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0331 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0452 0.0696
Plasmodium falciparum aldo-keto reductase, putative 0.0046 0.1182 1
Entamoeba histolytica aldose reductase, putative 0.0159 0.4691 1
Schistosoma mansoni chromobox protein 0.0057 0.1517 0.1513
Echinococcus multilocularis cpg binding protein 0.0025 0.0512 0.0509
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0077 0.2145 0.4116
Onchocerca volvulus 0.0024 0.0489 0.0814
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.4691 0.9008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Brugia malayi hypothetical protein 0.0024 0.0489 0.094
Echinococcus granulosus Chromo domain 0.0009 0.004 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0005 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Brugia malayi Associated with TFs and helicases family protein 0.0009 0.004 0.0078
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0159 0.4691 1
Trichomonas vaginalis chromobox protein, putative 0.0057 0.1517 0.2494
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.01 0.286 0.5723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0009 0.004 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1182 0.1929
Onchocerca volvulus 0.0046 0.1182 0.1978
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0116 0.0128
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0005 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0503 0.05
Trichomonas vaginalis chromobox protein, putative 0.0057 0.1517 0.2494
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0471 0.09
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0005 0.0002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0081 0.0079
Brugia malayi Doublecortin family protein 0.0024 0.0489 0.094
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Entamoeba histolytica serine/threonine protein kinase, putative 0.0077 0.2145 0.4525
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0489 0.0935
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Onchocerca volvulus 0.0023 0.0471 0.0783
Echinococcus granulosus hypothetical protein 0.0159 0.4691 0.469
Echinococcus multilocularis aldo keto reductase 0.0159 0.4691 0.469
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0009 0.004 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Entamoeba histolytica alcohol dehydrogenase, putative 0.0046 0.1182 0.2455
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.01 0.286 0.2858
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0005 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.4165 0.4164
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.041 0.324
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0489 0.0487
Schistosoma mansoni cpg binding protein 0.0023 0.0471 0.0467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0005 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Echinococcus multilocularis aldo keto reductase 0.0159 0.4691 0.469
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0005 0.0002
Schistosoma mansoni aldo-keto reductase 0.0159 0.4691 0.4689
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Loa Loa (eye worm) oxidoreductase 0.0159 0.4691 0.9007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0005 0.0009
Echinococcus granulosus Chromobox protein 3 0.0009 0.004 0.0038
Onchocerca volvulus 0.02 0.5959 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0489 0.0487
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Echinococcus granulosus chromobox protein 1 0.0057 0.1517 0.1514
Schistosoma mansoni lipoxygenase 0.0142 0.4165 0.4163
Trypanosoma cruzi polo-like protein kinase, putative 0.0077 0.2145 0.4052
Plasmodium vivax aldehyde reductase, putative 0.0046 0.1182 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.4165 0.4164
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Giardia lamblia Aldose reductase 0.0159 0.4691 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0005 0.0002
Schistosoma mansoni aldo-keto reductase 0.0159 0.4691 0.4689
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.4691 0.9008
Brugia malayi CXXC zinc finger family protein 0.0023 0.0471 0.0905
Schistosoma mansoni lipoxygenase 0.01 0.2837 0.2834
Echinococcus granulosus RUN 0.0024 0.0489 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0005 0.0009
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0159 0.4691 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0009 0.004 0.0038
Onchocerca volvulus 0.0159 0.4691 0.787
Brugia malayi nuclear hormone receptor 0.0008 0.0005 0.0009
Brugia malayi Valyl-tRNA synthetase 0.0009 0.004 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0331 1 1
Entamoeba histolytica aldose reductase, putative 0.0159 0.4691 1
Onchocerca volvulus 0.0025 0.0527 0.0878
Schistosoma mansoni rab6-interacting 0.0024 0.0489 0.0485
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.4691 0.7857
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Echinococcus granulosus aldehyde reductase 0.0113 0.326 0.3259
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0005 0.0009
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.4691 0.7857
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0548 0.0545
Loa Loa (eye worm) hypothetical protein 0.0021 0.041 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0741 0.1184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0005 0.0009
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Trypanosoma brucei prostaglandin f synthase 0.0159 0.4691 1
Onchocerca volvulus 0.0024 0.0489 0.0814
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0009 0.004 0.0036
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Trypanosoma brucei polo-like protein kinase 0.0077 0.2145 0.4052
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.2145 0.2141
Brugia malayi hypothetical protein 0.0009 0.004 0.0078
Entamoeba histolytica aldose reductase, putative 0.0159 0.4691 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.01 0.286 0.4782
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0046 0.1182 0.1929
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0005 0.0002
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.4691 0.7857
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.01 0.286 0.4782
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Schistosoma mansoni chromobox protein 0.0057 0.1517 0.1513
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0159 0.4691 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0005 0.0004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0005 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0837 0.0832
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Schistosoma mansoni chromobox protein 0.0009 0.004 0.0036
Schistosoma mansoni polycystin 1-related 0.0024 0.0489 0.0485
Toxoplasma gondii aldose reductase, putative 0.0159 0.4691 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0046 0.1182 0.118
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.4691 0.7857
Brugia malayi CHD4 protein 0.0011 0.0081 0.0156
Loa Loa (eye worm) helicase 0.0009 0.004 0.0072
Leishmania major prostaglandin f synthase, putative 0.0159 0.4691 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0005 0.0009
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0005 0.0004
Trypanosoma cruzi aldo/keto reductase, putative 0.0159 0.4691 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.1182 0.1929
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0046 0.1182 0.227
Echinococcus granulosus aldo keto reductase 0.0159 0.4691 0.469
Echinococcus multilocularis voltage gated potassium channel subunit 0.0046 0.1182 0.118
Schistosoma mansoni chromobox protein 0.0009 0.004 0.0036
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0005 0.0002
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.4691 0.7857
Loa Loa (eye worm) oxidoreductase 0.0159 0.4691 0.9007
Schistosoma mansoni potassium channel beta 0.0046 0.1182 0.1178
Echinococcus granulosus chromobox protein 2 0.0009 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0452 0.0696
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0489 0.0935
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0046 0.1182 0.2455
Schistosoma mansoni hypothetical protein 0.0009 0.004 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.041 0.324
Mycobacterium tuberculosis Probable oxidoreductase 0.0159 0.4691 1
Plasmodium falciparum aldehyde reductase, putative 0.0046 0.1182 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.1143 0.2372
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0489 0.3932
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.1307 0.1302
Echinococcus multilocularis aldo keto reductase 0.0159 0.4691 0.469
Echinococcus multilocularis chromobox protein 1 0.0057 0.1517 0.1514
Brugia malayi Pre-SET motif family protein 0.0176 0.5208 1
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.041 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0005 0.0009
Trichomonas vaginalis set domain proteins, putative 0.02 0.5959 1
Brugia malayi hypothetical protein 0.0021 0.041 0.0788
Mycobacterium ulcerans oxidoreductase 0.0159 0.4691 1
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0005 0.0002
Onchocerca volvulus 0.0159 0.4691 0.787
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0046 0.1182 0.118
Onchocerca volvulus 0.0159 0.4691 0.787
Echinococcus multilocularis Chromo domain 0.0009 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.01 0.286 0.2858
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0489 0.0487
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.4691 0.9008
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0077 0.2145 0.2143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0005 0.0009
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0077 0.2145 0.4052
Leishmania major aldo-keto reductase-like protein 0.0159 0.4691 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Brugia malayi chromobox protein homolog 3 0.0032 0.0741 0.1423
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.1182 0.1929
Schistosoma mansoni hypothetical protein 0.0024 0.0489 0.0485
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0009 0.004 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0548 0.0543
Brugia malayi NADH-dependent xylose reductase 0.0046 0.1182 0.227
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0005 0.0004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0005 0.0002
Echinococcus granulosus aldo keto reductase 0.0159 0.4691 0.469
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0936 0.1514
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0936 0.1514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0203 0.0275
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0489 0.3932
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0548 0.109
Echinococcus multilocularis Chromobox protein 3 0.0009 0.004 0.0038
Echinococcus multilocularis chromobox protein 2 0.0009 0.004 0.0038
Onchocerca volvulus Serine\/threonine kinase homolog 0.0077 0.2145 0.3594
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0176 0.5208 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Schistosoma mansoni loxhd1 0.0024 0.0489 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0005 0.0004
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0081 0.0077
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0005 0.0009
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0046 0.1182 0.2266
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0816 0.1363
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0005 0.0002
Trypanosoma cruzi aldo/keto reductase, putative 0.0046 0.1182 0.1803
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.4691 0.9008
Toxoplasma gondii aldehyde dehydrogenase 0.01 0.286 0.6063
Onchocerca volvulus 0.0159 0.4691 0.787
Loa Loa (eye worm) hypothetical protein 0.0024 0.0489 0.0935
Mycobacterium ulcerans aldehyde dehydrogenase 0.01 0.286 0.4782
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0005 0.0002
Trypanosoma brucei aldo/keto reductase, putative 0.0046 0.1182 0.1803
Echinococcus multilocularis chromobox protein 1 0.0057 0.1517 0.1514
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0816 0.1311
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0816 0.1311
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0046 0.1182 0.1803
Brugia malayi nuclear receptor NHR-88 0.0008 0.0005 0.0009
Schistosoma mansoni pol-related 0.0159 0.4691 0.4689
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.4691 0.469
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0072
Echinococcus granulosus chromobox protein 1 0.0057 0.1517 0.1514
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Loa Loa (eye worm) oxidoreductase 0.0159 0.4691 0.9007
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Onchocerca volvulus 0.0009 0.004 0.006
Loa Loa (eye worm) heterochromatin protein 1 0.0057 0.1517 0.2909
Echinococcus multilocularis aldo keto reductase 0.0159 0.4691 0.469
Trypanosoma cruzi aldo-keto reductase 0.0159 0.4691 1
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.041 0.324
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0005 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.01 0.286 0.2857
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.4691 0.7857
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.4691 0.469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0005 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0489 0.0487
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0077 0.2145 0.2143
Brugia malayi ecdysteroid receptor 0.0008 0.0005 0.0009
Brugia malayi hypothetical protein 0.0014 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Giardia lamblia Aldose reductase 0.0159 0.4691 1
Trypanosoma brucei aldo-keto reductase, putative 0.0159 0.4691 1
Loa Loa (eye worm) oxidoreductase 0.0159 0.4691 0.9007
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0005 0.0009
Brugia malayi Pre-SET motif family protein 0.0026 0.0548 0.1051
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0046 0.1182 1
Onchocerca volvulus 0.0159 0.4691 0.787
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0047 0.0044
Echinococcus granulosus aldo keto reductase 0.0159 0.4691 0.469
Brugia malayi steroid hormone receptor 0.0008 0.0005 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0005 0.0002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0009 0.004 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0548 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0005 0.0009
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0046 0.1182 0.2455
Schistosoma mansoni cpg binding protein 0.0025 0.0512 0.0508
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0203 0.0275
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0203 0.0275
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0004
Brugia malayi Heterochromatin protein 1 0.0057 0.1517 0.2913
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.2145 0.3556
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0005 0.0002
Brugia malayi Protein cec-1. 0.0009 0.004 0.0078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0527 0.1008
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0005 0.0009
Echinococcus multilocularis RUN 0.0024 0.0489 0.0487
Schistosoma mansoni kinase 0.0039 0.0968 0.0964
Brugia malayi M-phase phosphoprotein, mpp8 0.0009 0.004 0.0078
Brugia malayi SET domain containing protein 0.0011 0.0085 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.01 0.286 0.4782
Onchocerca volvulus 0.0159 0.4691 0.787
Loa Loa (eye worm) hypothetical protein 0.0032 0.0741 0.1418
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0047 0.0044

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) % Compound was tested to inhibit Leukotriene formation in A-23,187-stimulated mouse whole blood using LTB4 specific RIA ex vivo, activity expressed as percent of control; NT= Not tested ChEMBL. 8978834
Activity (functional) 0 % Compound was tested to inhibit Leukotriene formation in A-23,187-stimulated mouse whole blood using LTB4 specific RIA ex vivo, activity expressed as percent of control; NT= Not tested ChEMBL. 8978834
IC50 (binding) = 5.6 uM Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay. ChEMBL. 8978834
IC50 (binding) = 5.6 uM Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay. ChEMBL. 8978834

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.