Detailed information for compound 254864

Basic information

Technical information
  • TDR Targets ID: 254864
  • Name: (3S)-5-[(2-chlorophenyl)methylsulfanyl]-4-oxo -3-[[5-[[[3-(5-oxo-2H-1,2,4-oxadiazol-3-yl)ph enyl]sulfonylamino]methyl]thiophene-2-carbony l]amino]pentanoic acid
  • MW: 651.131 | Formula: C26H23ClN4O8S3
  • H donors: 4 H acceptors: 9 LogP: 3.65 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C[C@@H](C(=O)CSCc1ccccc1Cl)NC(=O)c1ccc(s1)CNS(=O)(=O)c1cccc(c1)c1noc(n1)O
  • InChi: 1S/C26H23ClN4O8S3/c27-19-7-2-1-4-16(19)13-40-14-21(32)20(11-23(33)34)29-25(35)22-9-8-17(41-22)12-28-42(37,38)18-6-3-5-15(10-18)24-30-26(36)39-31-24/h1-10,20,28H,11-14H2,(H,29,35)(H,33,34)(H,30,31,36)/t20-/m0/s1
  • InChiKey: USVOMZAPZHSFMM-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-5-[(2-chlorophenyl)methylthio]-4-oxo-3-[[oxo-[5-[[[3-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]sulfonylamino]methyl]-2-thienyl]methyl]amino]pentanoic acid
  • (3S)-5-[(2-chlorophenyl)methylsulfanyl]-4-oxo-3-[[5-[[[3-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]sulfonylamino]methyl]thiophen-2-yl]carbonylamino]pentanoic acid
  • (3S)-5-[(2-chlorobenzyl)thio]-4-keto-3-[[5-[[[3-(5-keto-2H-1,2,4-oxadiazol-3-yl)phenyl]sulfonylamino]methyl]thiophene-2-carbonyl]amino]valeric acid
  • Inhibitor 77

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0207 0.0665 0.1398
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0034 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0034 0.0042
Echinococcus granulosus dna polymerase eta 0.0049 0.0123 0.0172
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0051 0.0046
Echinococcus granulosus polycomb protein SCMH1 0.0036 0.0076 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0152
Schistosoma mansoni ran 0.0052 0.0132 0.0186
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0081 0.0168
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0056 0.0073
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0049 0.0123 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0204 0.0286
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0058 0.0063
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0108 0.0145
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0052 0.0132 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Schistosoma mansoni alpha-glucosidase 0.0116 0.0352 0.0494
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0034 0.0048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0052 0.0132 0.0127
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.003 0.0058 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Onchocerca volvulus Huntingtin homolog 0.0101 0.0299 0.2528
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0365 0.0399
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0114 0.016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0168
Trypanosoma cruzi metacaspase, putative 0.0032 0.0064 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0058 0.0074
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0225 0.0727 0.0722
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0151 0.047 0.2215
Brugia malayi Importin beta-1 subunit 0.0071 0.0196 0.0269
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0107 0.032 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0034 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0034 0.0141
Echinococcus granulosus importin subunit beta 1 0.0071 0.0196 0.0276
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0068 0.0186 0.0262
Echinococcus granulosus snurportin 1 0.0755 0.2543 0.3571
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0064 0.0083
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0076 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0052 0.0133 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0056 0.0073
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0056 0.0073
Plasmodium falciparum fructose-bisphosphate aldolase 0.0068 0.0186 0.0255
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0068 0.0186 0.0182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0032 0.0063
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2089 0.712 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0005 0.0007
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2089 0.712 1
Echinococcus granulosus caspase 3 0.0088 0.0255 0.0358
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0014
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0034 0.0141
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0064 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2928 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0034 0.0141
Leishmania major importin beta-1 subunit, putative 0.0057 0.015 0.0146
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0068 0.0186 0.0204
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0068 0.0186 0.0182
Schistosoma mansoni transcription factor LCR-F1 0.009 0.0264 0.0371
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0068 0.0186 0.0182
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2928 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0058 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.0446 0.062
Echinococcus granulosus cpg binding protein 0.0026 0.0041 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0049 0.0123 0.0166
Echinococcus granulosus caspase 8 0.0032 0.0064 0.0089
Trichomonas vaginalis glutaminase, putative 0.0433 0.144 0.2017
Echinococcus granulosus histone acetyltransferase MYST2 0.0041 0.0093 0.013
Echinococcus granulosus dna polymerase kappa 0.003 0.0058 0.0081
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0058 0.0081
Loa Loa (eye worm) hypothetical protein 0.0196 0.0625 0.1315
Echinococcus granulosus SAM and MBT domain containing protein 0.0036 0.0076 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0034 0.0042
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2089 0.712 1
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0123 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0041 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0104 0.0146
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0064 0.0059
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0034 0.0042
Schistosoma mansoni ran 0.0052 0.0132 0.0186
Schistosoma mansoni DNA polymerase eta 0.0049 0.0123 0.0172
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0056 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0204 0.0223
Schistosoma mansoni cpg binding protein 0.0026 0.0041 0.0058
Schistosoma mansoni alpha-glucosidase 0.0116 0.0352 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0014 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0056 0.0073
Echinococcus granulosus survival motor neuron protein 1 0.0196 0.0625 0.0878
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0058 0.0053
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0064 0.0083
Echinococcus multilocularis caspase 0.012 0.0365 0.0399
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0058 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0156
Echinococcus granulosus microtubule associated protein 2 0.1083 0.3669 0.5153
Brugia malayi N-terminal motif family protein 0.0138 0.0426 0.0593
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2089 0.712 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Echinococcus multilocularis muscleblind protein 1 0.0234 0.0757 0.0827
Echinococcus multilocularis lysosomal alpha glucosidase 0.0135 0.0416 0.0455
Trypanosoma brucei importin beta-1 subunit, putative 0.0071 0.0196 0.0191
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0755 0.2543 0.5355
Echinococcus multilocularis survival motor neuron protein 1 0.0196 0.0625 0.0684
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2089 0.712 0.7119
Brugia malayi RNA recognition motif domain containing protein 0.0052 0.0133 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0034 0.0042
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0052 0.0132 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0034 0.003
Brugia malayi Bromodomain containing protein 0.0061 0.0162 0.0221
Plasmodium vivax metacaspase 1, putative 0.0032 0.0064 0.0083
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0068 0.0186 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Loa Loa (eye worm) glutaminase 2 0.0433 0.144 0.303
Mycobacterium ulcerans lipase LipD 0.0024 0.0034 0.0042
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0138 0.0426 0.3739
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0064 0.0059
Mycobacterium tuberculosis Conserved protein 0.0024 0.0034 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.0204 0.0426
Echinococcus granulosus zinc finger protein 0.0017 0.0011 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0058 0.0074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.009 0.0264 0.0289
Echinococcus granulosus GTP binding nuclear protein Ran 0.0052 0.0132 0.0186
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0064 0.0302
Echinococcus multilocularis cpg binding protein 0.0026 0.0041 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Trypanosoma cruzi metacaspase, putative 0.0032 0.0064 0.0059
Trypanosoma brucei unspecified product 0.0021 0.0025 0.0021
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2089 0.712 0.7119
Echinococcus multilocularis Protein lozenge 0.0041 0.0096 0.0105
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0041 0.0093 0.0124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0052 0.0132 0.0127
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0056 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0204 0.0286
Brugia malayi jmjC domain containing protein 0.0044 0.0104 0.014
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0019 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0204 0.0223
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0003 0.0005
Echinococcus multilocularis dna polymerase kappa 0.003 0.0058 0.0063
Trypanosoma cruzi metacaspase, putative 0.0032 0.0064 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0627 0.2105 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0034 0.0141
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0123 0.0118
Schistosoma mansoni microtubule-associated protein tau 0.1083 0.3669 0.5153
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1319 0.4478 0.9434
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2089 0.712 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.033 0.1088 0.2288
Schistosoma mansoni myelin transcription factor 1 myt1 0.0041 0.0093 0.013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0123 0.0255
Brugia malayi mbt repeat family protein 0.0036 0.0076 0.01
Mycobacterium ulcerans beta-lactamase 0.0024 0.0034 0.0042
Entamoeba histolytica hypothetical protein 0.009 0.0264 0.0364
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0068 0.0186 0.0204
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0019 0.0021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0044 0.0104 0.0146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Leishmania major fructose-1,6-bisphosphate aldolase 0.0068 0.0186 0.0182
Loa Loa (eye worm) hypothetical protein 0.0234 0.0757 0.1591
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0081 0.0108
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0365 0.0512
Schistosoma mansoni importin beta-1 0.0071 0.0196 0.0276
Schistosoma mansoni ap endonuclease 0.0015 0.0005 0.0007
Brugia malayi Glycosyl hydrolases family 31 protein 0.0135 0.0416 0.0579
Brugia malayi glutaminase DH11.1 0.0433 0.144 0.2017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0049 0.0123 0.0118
Plasmodium vivax importin-beta 2, putative 0.0071 0.0196 0.0269
Loa Loa (eye worm) hypothetical protein 0.0101 0.0299 0.0626
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2928 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Schistosoma mansoni cpg binding protein 0.0026 0.0041 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0032 0.0062 0.0058
Trypanosoma brucei unspecified product 0.003 0.0058 0.0053
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0062 0.0058
Mycobacterium tuberculosis Conserved protein 0.0024 0.0034 0.0141
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0056 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0057 0.015 0.0205
Loa Loa (eye worm) hypothetical protein 0.0101 0.0299 0.0626
Schistosoma mansoni glutaminase 0.0433 0.144 0.2022
Trypanosoma brucei metacaspase 0.0032 0.0064 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.0071 0.0196 0.0191
Brugia malayi jmjC domain containing protein 0.0047 0.0114 0.0153
Trichomonas vaginalis esterase, putative 0.0024 0.0034 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0034 0.0042
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2089 0.712 1
Echinococcus granulosus caspase 2 0.0032 0.0064 0.0089
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0135 0.0416 0.0874
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0041 0.0093 0.0101
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0068 0.0186 0.0182
Loa Loa (eye worm) mbt repeat family protein 0.0036 0.0076 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.0446 0.062
Onchocerca volvulus 0.0024 0.0034 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0361 0.1695
Loa Loa (eye worm) hypothetical protein 0.0138 0.0426 0.0895
Treponema pallidum fructose-bisphosphate aldolase 0.1177 0.399 0.5601
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0056 0.0052
Leishmania major DNA polymerase eta, putative 0.0049 0.0123 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0039 0.0086 0.0081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.012 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0058 0.0053
Echinococcus multilocularis transcription factor Dp 1 0.0029 0.0051 0.0056
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1319 0.4478 0.9434
Brugia malayi beta-lactamase family protein 0.0024 0.0034 0.0042
Trypanosoma brucei Metacaspase-4 0.0032 0.0064 0.0059
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2089 0.712 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0058 0.0081
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.041
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2089 0.712 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0034 0.0141
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0692 0.2327 0.2323
Entamoeba histolytica hypothetical protein 0.009 0.0264 0.0364
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0034 0.0048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0204 0.0286
Echinococcus granulosus dnaJ subfamily B 0.0324 0.1065 0.1496
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0058 0.0074
Loa Loa (eye worm) runx1 0.0041 0.0096 0.0199
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1397 0.4747 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0052 0.0132 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0034 0.0048
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0064 0.0089
Brugia malayi mbt repeat family protein 0.0036 0.0076 0.01
Onchocerca volvulus 0.0078 0.0221 0.1796
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0049 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0052 0.0133 0.0186
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0052 0.0132 0.0144
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 0.7119
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0058 0.0074
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0052 0.0132 0.0127
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2089 0.712 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Loa Loa (eye worm) hypothetical protein 0.0234 0.0757 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0068 0.0186 0.0389
Onchocerca volvulus Glucosylceramidase homolog 0.0136 0.042 0.3682
Loa Loa (eye worm) beta-lactamase 0.0024 0.0034 0.0069
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 0.7119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.032 0.0315
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0052 0.0132 0.0179
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0058 0.0074
Echinococcus multilocularis lysine specific demethylase 5A 0.0044 0.0104 0.0114
Brugia malayi TAR-binding protein 0.0052 0.0133 0.018
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1462 0.4969 0.6976
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0056 0.0052
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0068 0.0186 0.0262
Brugia malayi RNA, U transporter 1 0.0201 0.0643 0.0897
Entamoeba histolytica hypothetical protein 0.009 0.0264 0.0364
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0068 0.0186 0.0262
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2089 0.712 0.7119
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.0021
Echinococcus multilocularis caspase 3 0.0088 0.0255 0.0279
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1319 0.4478 0.4896
Schistosoma mansoni hypothetical protein 0.0025 0.0041 0.0057
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0575 0.1926 0.9145
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0052 0.0132 0.0179
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0091 0.0121
Echinococcus granulosus tar DNA binding protein 0.0052 0.0133 0.0186
Plasmodium falciparum metacaspase 1 0.0032 0.0064 0.0083
Mycobacterium ulcerans hypothetical protein 0.0119 0.0361 0.05
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0068 0.0186 0.0204
Giardia lamblia DINP protein human, muc B family 0.003 0.0058 0.0074
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2089 0.712 1
Loa Loa (eye worm) hypothetical protein 0.033 0.1088 0.2288
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0056 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Brugia malayi beta-lactamase family protein 0.0024 0.0034 0.0042
Schistosoma mansoni hypothetical protein 0.0219 0.0706 0.0992
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0056 0.0073
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2089 0.712 1
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0068 0.0186 0.0255
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0068 0.0186 0.0255
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0068 0.0186 0.0182
Leishmania major metacaspase, putative 0.0032 0.0064 0.0059
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0365 0.0512
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0068 0.0186 0.0262
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0056 0.0079
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0049 0.0123 0.0255
Mycobacterium tuberculosis Conserved protein 0.0024 0.0034 0.0141
Schistosoma mansoni alpha glucosidase 0.003 0.0056 0.0079
Echinococcus multilocularis geminin 0.0399 0.1323 0.1446
Echinococcus granulosus muscleblind protein 0.0234 0.0757 0.1063
Onchocerca volvulus 0.033 0.1088 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0135 0.0416 0.0455
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0064 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0034 0.0042
Brugia malayi hypothetical protein 0.033 0.1088 0.1522
Schistosoma mansoni hypothetical protein 0.0399 0.1323 0.1858
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.001 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0064 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0143 0.0445 0.0625
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2089 0.712 0.7785
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2089 0.712 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0056 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0225 0.0727 0.0722
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Giardia lamblia Fructose-bisphosphate aldolase 0.1177 0.399 0.5601
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0000084556
Echinococcus multilocularis muscleblind protein 0.0234 0.0757 0.0827
Brugia malayi hypothetical protein 0.0196 0.0625 0.0872
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2089 0.712 0.7119
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1319 0.4478 0.6287
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0575 0.1926 0.9133
Echinococcus multilocularis SAM and MBT domain containing protein 0.0036 0.0076 0.0083
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0032 0.0062 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0068 0.0186 0.0255
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.012 0.0169
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0058 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0058 0.0053
Toxoplasma gondii HEAT repeat-containing protein 0.0071 0.0196 0.0269
Entamoeba histolytica Ran family GTPase 0.0052 0.0132 0.0179
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2679 0.9146 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0692 0.2327 0.2323
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.032 0.0315
Echinococcus multilocularis histone acetyltransferase MYST2 0.0041 0.0093 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0034 0.0141
Schistosoma mansoni survival motor neuron protein 0.004 0.0091 0.0127
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0051 0.0065
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0064 0.0083
Plasmodium falciparum importin beta, putative 0.0071 0.0196 0.0269
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2089 0.712 0.7119
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0365 0.0512
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0068 0.0186 0.0262
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0049 0.0123 0.0118
Brugia malayi hypothetical protein 0.0101 0.0299 0.0413
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.077 0.2595 0.3641
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1319 0.4478 0.629
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0692 0.2327 0.2323
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2089 0.712 1
Brugia malayi beta-lactamase 0.0024 0.0034 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0665 0.0928
Onchocerca volvulus Huntingtin homolog 0.0101 0.0299 0.2528
Trypanosoma brucei metacaspase MCA3 0.0032 0.0064 0.0059
Brugia malayi RNA binding protein 0.0052 0.0133 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.1319 0.4478 0.9434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2089 0.712 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0143 0.0445 0.0487
Brugia malayi hypothetical protein 0.009 0.0264 0.0364
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 0.7119
Mycobacterium ulcerans hypothetical protein 0.0024 0.0034 0.0042
Trypanosoma cruzi metacaspase, putative 0.0032 0.0064 0.0059
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0225 0.0727 0.0722
Brugia malayi CXXC zinc finger family protein 0.0023 0.0032 0.0038
Leishmania major mitochondrial DNA polymerase beta 0.0225 0.0727 0.0722
Echinococcus granulosus geminin 0.0399 0.1323 0.1858
Echinococcus granulosus histone lysine methyltransferase setb 0.0014 0.0002 0.0002
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0068 0.0186 0.0389
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0068 0.0186 0.0204
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0052 0.0133 0.0276
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1397 0.4747 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0052 0.0133 0.0186
Loa Loa (eye worm) TAR-binding protein 0.0052 0.0133 0.0276
Loa Loa (eye worm) MBCTL1 0.0041 0.0093 0.0192
Trichomonas vaginalis importin beta-1, putative 0.0057 0.015 0.0205
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0207 0.0665 0.0928
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0005 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0034 0.003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1319 0.4478 0.6287
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2089 0.712 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Schistosoma mansoni hypothetical protein 0.009 0.0264 0.0371
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0692 0.2327 0.2323
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0076 0.0106
Trypanosoma brucei glucosidase, putative 0.003 0.0056 0.0052
Echinococcus multilocularis caspase 2 0.0032 0.0064 0.007
Leishmania major DNA polymerase kappa, putative 0.003 0.0058 0.0053
Schistosoma mansoni lozenge 0.0041 0.0096 0.0135
Echinococcus multilocularis importin subunit beta 1 0.0071 0.0196 0.0214
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0692 0.2327 0.3264
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2089 0.712 0.7119
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0034 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0058 0.0053
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0692 0.2327 0.2323
Plasmodium falciparum metacaspase-like protein 0.0032 0.0064 0.0083
Echinococcus granulosus transcription factor Dp 1 0.0029 0.0051 0.0072
Brugia malayi Cell death protein 3 precursor 0.0032 0.0064 0.0083
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.077 0.2595 0.3641
Schistosoma mansoni tar DNA-binding protein 0.0052 0.0133 0.0186
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0036 0.0076 0.0417
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0056 0.0073
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0058 0.0053
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2089 0.712 1
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0034 0.0042
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2089 0.712 0.7119
Trypanosoma brucei unspecified product 0.0021 0.0025 0.0021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0058 0.0118
Trichomonas vaginalis ran, putative 0.0052 0.0132 0.0179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0058 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0056 0.0073
Leishmania major hypothetical protein, conserved 0.0024 0.0034 0.003
Echinococcus multilocularis tar DNA binding protein 0.0052 0.0133 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0034 0.003
Echinococcus multilocularis zinc finger protein 0.0017 0.0011 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0204 0.0286
Schistosoma mansoni cpg binding protein 0.0023 0.0032 0.0045
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0036 0.0076 0.0106
Brugia malayi Muscleblind-like protein 0.0234 0.0757 0.1057
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0058 0.0081
Echinococcus multilocularis dna polymerase eta 0.0049 0.0123 0.0134
Schistosoma mansoni ap endonuclease 0.0015 0.0005 0.0007
Leishmania major GTP-binding protein, putative 0.0052 0.0132 0.0127
Schistosoma mansoni hypothetical protein 0.004 0.0091 0.0127
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0052 0.0132 0.0179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0051 0.0056
Onchocerca volvulus 0.004 0.0091 0.0558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0041 0.0093 0.013
Entamoeba histolytica hypothetical protein 0.0057 0.015 0.0205
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0114 0.016
Brugia malayi PHD-finger family protein 0.0021 0.0026 0.003
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2089 0.712 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0056 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0064 0.0083
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0056 0.0073
Onchocerca volvulus 0.0024 0.0034 0.0026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0051 0.0072
Loa Loa (eye worm) RNA binding protein 0.0052 0.0133 0.0276
Brugia malayi fructose-bisphosphate aldolase 1 0.0068 0.0186 0.0255
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0114 0.0236
Loa Loa (eye worm) glutaminase 0.0433 0.144 0.303
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2089 0.712 1
Echinococcus multilocularis microtubule associated protein 2 0.1083 0.3669 0.4012
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0049 0.0123 0.0134
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0627 0.2105 1
Echinococcus multilocularis caspase 8 0.0032 0.0064 0.007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0057 0.015 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0034 0.0042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.0204 0.028
Echinococcus multilocularis dnaJ subfamily B 0.0324 0.1065 0.1165
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.003 0.0058 0.0251
Schistosoma mansoni hypothetical protein 0.0324 0.1065 0.1496
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0049 0.0123 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0204 0.0286
Brugia malayi fructose-bisphosphate aldolase 2 0.0068 0.0186 0.0255
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0049 0.0123 0.0172
Echinococcus granulosus lysosomal alpha glucosidase 0.0135 0.0416 0.0585
Toxoplasma gondii ABC1 family protein 0.0024 0.0034 0.0042
Onchocerca volvulus 0.0036 0.0076 0.0417
Echinococcus granulosus caspase 0.012 0.0365 0.0512
Leishmania major DNA polymerase eta, putative 0.0028 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0069
Schistosoma mansoni hypothetical protein 0.0755 0.2543 0.3571
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2089 0.712 0.7119
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2089 0.712 0.7785
Toxoplasma gondii hypothetical protein 0.0036 0.0078 0.0103
Echinococcus multilocularis snurportin 1 0.0755 0.2543 0.278
Schistosoma mansoni zinc finger protein 0.0017 0.0011 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0056 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0057 0.015 0.0205
Entamoeba histolytica hypothetical protein 0.009 0.0264 0.0364
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0114 0.016
Trypanosoma brucei metacaspase MCA2 0.0032 0.0064 0.0059
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0123 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0058 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0119 0.0167
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0575 0.1926 0.27
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.009 0.0264 0.0371
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0064 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1177 0.399 0.5601
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0034 0.0038
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2089 0.712 0.7119
Mycobacterium ulcerans glutaminase 0.0433 0.144 0.2017
Echinococcus multilocularis polycomb protein SCMH1 0.0036 0.0076 0.0083
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0068 0.0186 0.0255
Brugia malayi Bromodomain containing protein 0.003 0.0058 0.0074
Onchocerca volvulus 0.0024 0.0034 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0052 0.0133 0.0186
Schistosoma mansoni bromodomain containing protein 0.0051 0.013 0.0183
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0131
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0019 0.0027
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0049 0.0123 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.042 0.0584
Schistosoma mansoni hypothetical protein 0.0399 0.1323 0.1858
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0044 0.0104 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0081 0.0108
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2089 0.712 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.31 uM Inhibitory activity against Caspase-3 ChEMBL. 12408711
Ki (binding) = 0.31 uM Inhibitory activity against Caspase-3 ChEMBL. 12408711

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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