Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.077 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0052 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0347 | 0.4112 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0347 | 0.4112 | 1 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.077 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.077 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.077 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.077 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.077 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0052 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 0.4112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.4112 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.077 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 0.4112 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.4112 | 1 |
Onchocerca volvulus | 0.0319 | 0.3719 | 0.9045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4700 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Ki app (binding) | = 4700 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.