Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | pteridine reductase 1 | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0029 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0427 | 0.5484 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0029 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1669 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0029 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0427 | 0.5484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1669 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0427 | 0.5484 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0427 | 0.5484 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0029 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0427 | 0.5484 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0029 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0029 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0427 | 0.5484 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.1669 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0427 | 0.5484 | 0.5484 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.1669 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0427 | 0.5484 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1669 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1669 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0029 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0427 | 0.5484 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.12 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Log Ki (binding) | = 7.12 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.