TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 611.729 | Formula: C32H45N5O7
H donors: 4 H acceptors: 6 LogP: 3.79 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CC[C@H]([C@@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H]2N(C1=O)CCCC2)CCCCCC(=O)O)Cc1cn(c2c1cccc2)OC)C
InChi: 1S/C32H45N5O7/c1-4-20(2)28-32(43)36-17-11-10-15-26(36)31(42)33-23(13-6-5-7-16-27(38)39)29(40)34-24(30(41)35-28)18-21-19-37(44-3)25-14-9-8-12-22(21)25/h8-9,12,14,19-20,23-24,26,28H,4-7,10-11,13,15-18H2,1-3H3,(H,33,42)(H,34,40)(H,35,41)(H,38,39)/t20?,23-,24-,26+,28-/m0/s1
InChiKey: VXHZOOMBKKPXQS-MEXPMVNWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	histone deacetylase, putative	0.0355	0.0158	0.0158
Echinococcus granulosus	Oxysterol binding protein 11	0.0328	0.0136	0.0203
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0328	0.0136	0.0203
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	FTZ F1 alpha	0.0452	0.0241	0.0359
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0452	0.0241	0.0241
Brugia malayi	hypothetical protein	0.0213	0.0038	0.0038
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0328	0.0136	0.014
Brugia malayi	conserved hypotetical protein	0.0213	0.0038	0.0038
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Echinococcus granulosus	oxysterol binding protein 9	0.0328	0.0136	0.0203
Echinococcus granulosus	pleckstrin y domain containing family A	0.0328	0.0136	0.0203
Trypanosoma brucei	histone deacetylase 4	0.0355	0.0158	0.0158
Schistosoma mansoni	histone deacetylase 4 5	0.0355	0.0158	0.0237
Loa Loa (eye worm)	AGC/NDR protein kinase	0.3991	0.3238	0.3238
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.3991	0.3238	0.3238
Trypanosoma brucei	histone deacetylase 1	0.0388	0.0186	0.0186
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0452	0.0241	0.0359
Brugia malayi	Protein kinase domain containing protein	0.3991	0.3238	0.3238
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0388	0.0186	0.0105
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Entamoeba histolytica	protein kinase, putative	0.0414	0.0209	0.0074
Schistosoma mansoni	vav2	0.0328	0.0136	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0452	0.0241	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0452	0.0241	0.0241
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0452	0.0241	0.0241
Onchocerca volvulus		0.0328	0.0136	0.5642
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0452	0.0241	0.0241
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0328	0.0136	0.5642
Loa Loa (eye worm)	DR-78	0.0213	0.0038	0.0038
Entamoeba histolytica	protein kinase, putative	1.1973	1	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0328	0.0136	0.0136
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0213	0.0038	0.0057
Echinococcus multilocularis	histone deacetylase 6	0.0355	0.0158	0.0237
Echinococcus granulosus	histone deacetylase	0.0355	0.0158	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0452	0.0241	0.0241
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Echinococcus granulosus	serine threonine protein kinase nrc	0.774	0.6414	0.9584
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0239	0.006	0.009
Trypanosoma cruzi	histone deacetylase 1, putative	0.0388	0.0186	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.7654	0.6341	0.9475
Toxoplasma gondii	hypothetical protein	0.0328	0.0136	0.014
Brugia malayi	Oxysterol binding protein	0.0328	0.0136	0.0136
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0452	0.0241	0.0359
Trichomonas vaginalis	hypothetical protein	0.0328	0.0136	0.0054
Echinococcus granulosus	myotubularin protein 13	0.0328	0.0136	0.0203
Brugia malayi	probable spectrin beta chain	0.0328	0.0136	0.0136
Toxoplasma gondii	AGC kinase	1.1645	0.9722	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0328	0.0136	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0452	0.0241	0.0241
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Echinococcus granulosus	histone deacetylase 3	0.0388	0.0186	0.0278
Brugia malayi	hypothetical protein	0.0328	0.0136	0.0136
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	histone deacetylase 1	0.0388	0.0186	0.0186
Loa Loa (eye worm)	oxysterol binding protein	0.0328	0.0136	0.0136
Brugia malayi	nuclear hormone receptor	0.0213	0.0038	0.0038
Leishmania major	folate/biopterin transporter, putative	0.0414	0.0209	1
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0452	0.0241	0.0241
Brugia malayi	hypothetical protein	0.0239	0.006	0.006
Schistosoma mansoni	myotubularin-related protein	0.0328	0.0136	0.0203
Brugia malayi	Histone deacetylase family protein	0.0355	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0414	0.0209	1
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Plasmodium vivax	histone deacetylase 1, putative	0.0388	0.0186	0.029
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0452	0.0241	0.0359
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0328	0.0136	0.0203
Brugia malayi	Variant SH3 domain containing protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0328	0.0136	0.0203
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0452	0.0241	0.0359
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Echinococcus multilocularis	ecdysone induced protein 78C	0.0452	0.0241	0.0359
Echinococcus granulosus	dynamin 1	0.0328	0.0136	0.0203
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Echinococcus multilocularis	Pleckstrin y	0.0328	0.0136	0.0203
Brugia malayi	Histone deacetylase 1	0.0388	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus granulosus	histone deacetylase 7	0.0355	0.0158	0.0237
Schistosoma mansoni	atypical protein kinase C	0.3991	0.3238	0.4838
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0452	0.0241	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0239	0.006	0.006
Brugia malayi	orphan nuclear receptor NR2E1	0.0213	0.0038	0.0038
Trypanosoma brucei	rac serine-threonine kinase, putative	1.1973	1	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.3991	0.3238	0.3238
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0414	0.0209	0.0074
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0328	0.0136	0.0203
Echinococcus granulosus	histone deacetylase 1	0.0388	0.0186	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.3991	0.3238	0.3182
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Brugia malayi	TBC domain containing protein	0.0328	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor E75	0.0213	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0213	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Brugia malayi	nuclear receptor NHR-67	0.0213	0.0038	0.0038
Schistosoma mansoni	nuclear hormone receptor	0.0213	0.0038	0.0057
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Brugia malayi	Hr1 repeat family protein	0.3991	0.3238	0.3238
Onchocerca volvulus	Protein melted homolog	0.0328	0.0136	0.5642
Giardia lamblia	Kinase, AGC PKA	0.774	0.6414	1
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Echinococcus granulosus	Rho GTPase activating protein 24	0.0328	0.0136	0.0203
Onchocerca volvulus	Putative zinc finger protein	0.0328	0.0136	0.5642
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0213	0.0038	0.0057
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0452	0.0241	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0414	0.0209	0.0215
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Echinococcus multilocularis	nervana 2	0.7654	0.6341	0.9475
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0328	0.0136	0.0203
Trypanosoma brucei	histone deacetylase 3	0.0355	0.0158	0.0158
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Brugia malayi	Pleckstrin Homology Domain	0.0328	0.0136	0.0136
Loa Loa (eye worm)	histone deacetylase 7A	0.0355	0.0158	0.0158
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0414	0.0209	0.0312
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0328	0.0136	0.0203
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0328	0.0136	0.0203
Trichomonas vaginalis	alpha chimerin, putative	0.0328	0.0136	0.0054
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0414	0.0209	0.0209
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0414	0.0209	0.0074
Brugia malayi	Nuclear hormone receptor-like 1	0.0239	0.006	0.006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0452	0.0241	0.0241
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0239	0.006	0.006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0452	0.0241	0.0359
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Trichomonas vaginalis	kinesin light chain, putative	0.0328	0.0136	0.0054
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0328	0.0136	0.0203
Plasmodium falciparum	histone deacetylase, putative	0.0355	0.0158	0.0036
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.4319	0.3516	0.3463
Echinococcus multilocularis	histone deacetylase 6	0.0363	0.0165	0.0246
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0452	0.0241	0.0241
Echinococcus granulosus	nervana 2	0.7654	0.6341	0.9475
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Brugia malayi	tailless protein	0.0213	0.0038	0.0038
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0213	0.0038	0.159
Schistosoma mansoni	oxysterol-binding protein 1	0.0328	0.0136	0.0203
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.774	0.6414	0.9584
Plasmodium vivax	hypothetical protein, conserved	0.0328	0.0136	0.0212
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.3991	0.3238	0.3238
Echinococcus multilocularis	cytohesin 1	0.0328	0.0136	0.0203
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.3991	0.3238	0.3238
Echinococcus multilocularis	oxysterol binding protein 1	0.0328	0.0136	0.0203
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0213	0.0038	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Trypanosoma cruzi	NIMA-related kinase, putative	0.0414	0.0209	0.0312
Trypanosoma cruzi	histone deacetylase, putative	0.0355	0.0158	0.0237
Onchocerca volvulus		0.0328	0.0136	0.5642
Schistosoma mansoni	hypothetical protein	0.0328	0.0136	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Schistosoma mansoni	histone deacetylase hda2	0.0363	0.0165	0.0246
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0239	0.006	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	dynamin 1	0.0328	0.0136	0.0203
Echinococcus granulosus	protein kinase c iota type	0.3991	0.3238	0.4838
Onchocerca volvulus		0.0265	0.0082	0.3405
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0213	0.0038	0.0057
Onchocerca volvulus		0.0213	0.0038	0.159
Brugia malayi	Oxysterol-binding protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Schistosoma mansoni	serine/threonine-protein kinase	0.8069	0.6693	1
Trichomonas vaginalis	centaurin gamma, putative	0.0328	0.0136	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Schistosoma mansoni	nuclear receptor nhr-48	0.0213	0.0038	0.0057
Echinococcus granulosus	thyroid hormone receptor alpha	0.0213	0.0038	0.0057
Trypanosoma cruzi	PH domain containing protein, putative	0.0328	0.0136	0.0203
Schistosoma mansoni	histone deacetylase	0.0388	0.0186	0.0278
Brugia malayi	photoreceptor-specific nuclear receptor	0.0452	0.0241	0.0241
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0414	0.0209	0.0209
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Loa Loa (eye worm)	uncoordinated protein 104	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Brugia malayi	nuclear receptor RXR	0.0213	0.0038	0.0038
Schistosoma mansoni	nuclear hormone receptor	0.0213	0.0038	0.0057
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0239	0.006	0.006
Schistosoma mansoni	serine/threonine-protein kinase	0.8069	0.6693	1
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Toxoplasma gondii	hypothetical protein	0.0328	0.0136	0.014
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0328	0.0136	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0328	0.0136	0.0203
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0213	0.0038	0.0057
Echinococcus multilocularis	histone deacetylase 6	0.0355	0.0158	0.0237
Trypanosoma cruzi	Protein kinase B	0.8069	0.6693	1
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Brugia malayi	nuclear hormone receptor	0.0452	0.0241	0.0241
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0452	0.0241	0.0359
Echinococcus granulosus	Pleckstrin y	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0239	0.006	0.006
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0414	0.0209	1
Schistosoma mansoni	goodpasture antigen-binding protein	0.0328	0.0136	0.0203
Echinococcus granulosus	nuclear receptor nhr 48	0.0213	0.0038	0.0057
Schistosoma mansoni	nuclear receptor	0.0213	0.0038	0.0057
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Echinococcus granulosus	protein kinase c epsilon type	0.3991	0.3238	0.4838
Plasmodium falciparum	histone deacetylase 2	0.0355	0.0158	0.0036
Schistosoma mansoni	centaurin alpha	0.0328	0.0136	0.0203
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0414	0.0209	0.0074
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0213	0.0038	0.0057
Brugia malayi	Dynamin	0.0328	0.0136	0.0136
Echinococcus granulosus	calcium dependent secretion activator 1	0.0328	0.0136	0.0203
Leishmania major	histone deacetylase, putative	0.0355	0.0158	0.3117
Brugia malayi	nuclear receptor NHR-88	0.0452	0.0241	0.0241
Schistosoma mansoni	coup transcription factor	0.0452	0.0241	0.0359
Trypanosoma cruzi	PH domain containing protein, putative	0.0328	0.0136	0.0203
Entamoeba histolytica	protein kinase 2, putative	0.774	0.6414	0.6365
Loa Loa (eye worm)	Plekhf2 protein	0.0328	0.0136	0.0136
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0452	0.0241	0.0359
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0388	0.0186	0.0105
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.7654	0.6341	0.9475
Echinococcus multilocularis	Glutaredoxin protein 5	0.7654	0.6341	0.9475
Brugia malayi	ecdysteroid receptor	0.0452	0.0241	0.0241
Trypanosoma cruzi	histone deacetylase, putative	0.0355	0.0158	0.0237
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0328	0.0136	0.5642
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.3991	0.3238	0.4838
Schistosoma mansoni	hypothetical protein	0.0328	0.0136	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Brugia malayi	steroid hormone receptor	0.0452	0.0241	0.0241
Entamoeba histolytica	protein kinase, putative	0.0414	0.0209	0.0074
Echinococcus granulosus	protein kinase C gamma type	0.3991	0.3238	0.4838
Echinococcus multilocularis	oxysterol binding protein 9	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Entamoeba histolytica	protein kinase, putative	0.0414	0.0209	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0414	0.0209	0.0312
Schistosoma mansoni	hypothetical protein	0.0328	0.0136	0.0203
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0328	0.0136	0.0136
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Brugia malayi	histone deacetylase 3 (HD3)	0.0388	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Trichomonas vaginalis	centaurin beta, putative	0.0328	0.0136	0.0054
Leishmania major	histone deacetylase, putative	0.0388	0.0186	0.6917
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0328	0.0136	0.0203
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.774	0.6414	1
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Loa Loa (eye worm)	steroid hormone receptor	0.0452	0.0241	0.0241
Brugia malayi	Histone deacetylase family protein	0.0355	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0452	0.0241	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Echinococcus granulosus	beta 1 syntrophin	0.0328	0.0136	0.0203
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0328	0.0136	0.0136
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0328	0.0136	0.0212
Schistosoma mansoni	RAR-like nuclear receptor	0.0452	0.0241	0.0359
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0452	0.0241	0.0359
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0328	0.0136	0.0136
Echinococcus granulosus	oxysterol binding protein 1	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Echinococcus granulosus	FTZ F1 alpha	0.0452	0.0241	0.0359
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0452	0.0241	0.0359
Plasmodium falciparum	histone deacetylase 1	0.0388	0.0186	0.008
Entamoeba histolytica	hypothetical protein	0.0414	0.0209	0.0074
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.3991	0.3238	0.4838
Echinococcus multilocularis	oxysterol binding protein 3	0.0328	0.0136	0.0203
Echinococcus multilocularis	serine threonine protein kinase	0.3991	0.3238	0.4838
Onchocerca volvulus		0.0213	0.0038	0.159
Schistosoma mansoni	hypothetical protein	0.0328	0.0136	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0452	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Schistosoma mansoni	growth factor receptor-bound protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	AGC/AKT protein kinase	1.1973	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Entamoeba histolytica	protein kinase, putative	0.3991	0.3238	0.3145
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0328	0.0136	0.0203
Trypanosoma cruzi	PH domain containing protein, putative	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0328	0.0136	0.0203
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Echinococcus granulosus	oxysterol binding protein 3	0.0328	0.0136	0.0203
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0414	0.0209	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0328	0.0136	0.0203
Trichomonas vaginalis	protein transport protein sec7, putative	0.0328	0.0136	0.0054
Echinococcus multilocularis	histone deacetylase 1	0.0388	0.0186	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0213	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0022	0.0022
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0328	0.0136	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Onchocerca volvulus		0.0328	0.0136	0.5642
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.3991	0.3238	0.4838
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0328	0.0136	0.0136
Schistosoma mansoni	dynamin	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Entamoeba histolytica	PH domain containing protein kinase, putative	0.8069	0.6693	0.6647
Schistosoma mansoni	thyroid hormone receptor	0.0452	0.0241	0.0359
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0414	0.0209	0.0215
Schistosoma mansoni	nuclear hormone receptor	0.0452	0.0241	0.0359
Schistosoma mansoni	rho gtpase activating protein	0.0328	0.0136	0.0203
Schistosoma mansoni	dynamin	0.0328	0.0136	0.0203
Brugia malayi	nuclear receptor NHR-88	0.0213	0.0038	0.0038
Plasmodium vivax	PH domain containing protein	0.0328	0.0136	0.0212
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0328	0.0136	0.0203
Brugia malayi	hypothetical protein	0.0213	0.0038	0.0038
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0328	0.0136	0.0203
Echinococcus granulosus	Pleckstrin y	0.0328	0.0136	0.0203
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Echinococcus multilocularis	rac serine:threonine kinase	0.8069	0.6693	1
Onchocerca volvulus		0.0328	0.0136	0.5642
Echinococcus granulosus	NDR protein kinase	0.3991	0.3238	0.4838
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Trichomonas vaginalis	AGC family protein kinase	0.3991	0.3238	0.3182
Echinococcus multilocularis	Pleckstrin y	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0239	0.006	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus granulosus	nervana 2	0.7654	0.6341	0.9475
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0414	0.0209	0.0209
Leishmania major	histone deacetylase, putative	0.0388	0.0186	0.6917
Brugia malayi	Syntrophin-1	0.0328	0.0136	0.0136
Echinococcus granulosus	Glutaredoxin protein 5	0.7654	0.6341	0.9475
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0239	0.006	0.006
Onchocerca volvulus		0.0328	0.0136	0.5642
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0452	0.0241	0.0359
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0213	0.0038	0.0038
Trypanosoma cruzi	hypothetical protein	0.0328	0.0136	0.0203
Echinococcus multilocularis	Pleckstrin y	0.0328	0.0136	0.0203
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0328	0.0136	0.0054
Onchocerca volvulus		0.0328	0.0136	0.5642
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus granulosus	Protein kinase C brain isozyme	0.3991	0.3238	0.4838
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0213	0.0038	0.0057
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0452	0.0241	0.0359
Echinococcus multilocularis	actin binding protein anillin	0.0328	0.0136	0.0203
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0213	0.0038	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0328	0.0136	0.0203
Toxoplasma gondii	histone deacetylase HDAC3	0.0388	0.0186	0.0191
Brugia malayi	ecdysone receptor	0.0213	0.0038	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.3991	0.3238	0.3182
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0414	0.0209	0.0325
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0213	0.0038	0.0038
Schistosoma mansoni	thyroid hormone receptor	0.0452	0.0241	0.0359
Brugia malayi	Nuclear hormone receptor-like 1	0.0452	0.0241	0.0241
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0452	0.0241	0.0241
Schistosoma mansoni	zinc finger protein	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Echinococcus granulosus	serine/threonine protein kinase	0.8069	0.6693	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Entamoeba histolytica	protein kinase, putative	1.1645	0.9722	0.9718
Echinococcus granulosus	DCC interacting protein 13 beta	0.0328	0.0136	0.0203
Trypanosoma brucei	PH domain containing protein, putative	0.0328	0.0136	0.0136
Onchocerca volvulus		0.0452	0.0241	1
Schistosoma mansoni	syntrophin	0.0328	0.0136	0.0203
Brugia malayi	Pre-SET motif family protein	0.0233	0.0055	0.0055
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.3991	0.3238	0.4838
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0414	0.0209	0.0209
Loa Loa (eye worm)	histone deacetylase 3	0.0388	0.0186	0.0186
Brugia malayi	protein kinase C II.	0.3991	0.3238	0.3238
Schistosoma mansoni	hypothetical protein	0.0328	0.0136	0.0203
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.8069	0.6693	1
Entamoeba histolytica	protein kinase, putative	0.0414	0.0209	0.0074
Loa Loa (eye worm)	cytohesin 3	0.0328	0.0136	0.0136
Onchocerca volvulus	outspread protein homolog	0.0328	0.0136	0.5642
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0452	0.0241	0.0241
Echinococcus granulosus	histone deacetylase 6	0.0363	0.0165	0.0246
Schistosoma mansoni	zinc finger protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0213	0.0038	0.159
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0016	0.0016
Echinococcus multilocularis	pdz domain containing protein	0.0328	0.0136	0.0203
Echinococcus multilocularis	histone deacetylase 7	0.0355	0.0158	0.0237
Toxoplasma gondii	histone deacetylase HDAC1	0.0355	0.0158	0.0163
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0213	0.0038	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor-like 1	0.0239	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Schistosoma mansoni	serine/threonine kinase	0.3991	0.3238	0.4838
Echinococcus multilocularis	protein kinase c iota type	0.3991	0.3238	0.4838
Echinococcus multilocularis	Oxysterol binding protein 11	0.0328	0.0136	0.0203
Brugia malayi	Nuclear hormone receptor E75	0.0213	0.0038	0.0038
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0452	0.0241	0.0359
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0452	0.0241	0.0241
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0414	0.0209	0.0312
Brugia malayi	nuclear hormone receptor family member odr-7	0.0213	0.0038	0.0038
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0328	0.0136	0.0054
Brugia malayi	nuclear receptor RXR	0.0239	0.006	0.006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0452	0.0241	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Echinococcus granulosus	Pleckstrin y	0.0328	0.0136	0.0203
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0328	0.0136	0.0212
Echinococcus multilocularis	histone deacetylase 3	0.0388	0.0186	0.0278
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0452	0.0241	0.0359
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Plasmodium vivax	histone deacetylase, putative	0.0355	0.0158	0.0247
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.3904	0.3165	0.3109
Echinococcus granulosus	serine:threonine protein kinase N2	0.3991	0.3238	0.4838
Trypanosoma cruzi	PH domain containing protein, putative	0.0328	0.0136	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Echinococcus granulosus	ecdysone induced protein 78C	0.0452	0.0241	0.0359
Trypanosoma cruzi	histone deacetylase, putative	0.0355	0.0158	0.0237
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	histone deacetylase	0.0355	0.0158	0.0158
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0213	0.0038	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Loa Loa (eye worm)	PH domain-containing protein	0.0328	0.0136	0.0136
Brugia malayi	Cadps2 protein	0.0328	0.0136	0.0136
Brugia malayi	Plekhf2 protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0328	0.0136	0.0054
Entamoeba histolytica	histone deacetylase, putative	0.0388	0.0186	0.0051
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0414	0.0209	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus granulosus	histone deacetylase 6	0.0355	0.0158	0.0237
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.3991	0.3238	0.4838
Schistosoma mansoni	retinoic acid receptor RXR	0.0452	0.0241	0.0359
Onchocerca volvulus		0.0328	0.0136	0.5642
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.774	0.6414	0.9584
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Schistosoma mansoni	goodpasture antigen-binding protein	0.0328	0.0136	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Echinococcus multilocularis	serine:threonine protein kinase 38	0.3991	0.3238	0.4838
Schistosoma mansoni	nuclear receptor	0.0213	0.0038	0.0057
Trypanosoma brucei	protein kinase, putative	0.0414	0.0209	0.0209
Echinococcus multilocularis	beta 1 syntrophin	0.0328	0.0136	0.0203
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.3991	0.3238	0.4838
Loa Loa (eye worm)	nuclear hormone receptor	0.0213	0.0038	0.0038
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0452	0.0241	0.0241
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0414	0.0209	0.0128
Trypanosoma cruzi	NIMA-related kinase, putative	0.0414	0.0209	0.0312
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0328	0.0136	0.0136
Loa Loa (eye worm)	AGC/PKN protein kinase	0.3991	0.3238	0.3238
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0452	0.0241	0.0241
Echinococcus granulosus	histone deacetylase 6	0.0355	0.0158	0.0237
Entamoeba histolytica	protein kinase, putative	1.1973	1	1
Echinococcus granulosus	pdz domain containing protein	0.0328	0.0136	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0414	0.0209	0.0128
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0328	0.0136	0.0203
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0452	0.0241	0.0359
Plasmodium vivax	histone deacetylase 2, putative	0.0355	0.0158	0.0247
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0328	0.0136	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0328	0.0136	0.0203
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0452	0.0241	0.0241
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	1.1645	0.9722	0.9722
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0452	0.0241	0.0359
Schistosoma mansoni	histone deacetylase	0.0388	0.0186	0.0278
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0328	0.0136	0.0203
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.774	0.6414	0.9584
Trichomonas vaginalis	centaurin alpha, putative	0.0328	0.0136	0.0054
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0328	0.0136	0.0203
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0452	0.0241	0.0359
Onchocerca volvulus	Protein ultraspiracle homolog	0.0452	0.0241	1
Brugia malayi	PH domain containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0328	0.0136	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0038	0.0038
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0388	0.0186	0.0105
Brugia malayi	Cytohesin 3	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0414	0.0209	0.0074
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0452	0.0241	0.0359
Brugia malayi	MAX-1A	0.0328	0.0136	0.0136
Trichomonas vaginalis	histone deacetylase, putative	0.0388	0.0186	0.0105
Echinococcus multilocularis	myotubularin protein 13	0.0328	0.0136	0.0203
Loa Loa (eye worm)	syntrophin-1	0.0328	0.0136	0.0136
Entamoeba histolytica	p21-activated kinase	0.0414	0.0209	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Toxoplasma gondii	histone deacetylase HDAC2	0.0388	0.0186	0.0191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0452	0.0241	0.0241
Echinococcus multilocularis	nuclear receptor nhr 48	0.0213	0.0038	0.0057
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0452	0.0241	0.0359
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Echinococcus multilocularis	nervana 2	0.7654	0.6341	0.9475
Entamoeba histolytica	protein kinase, putative	0.0414	0.0209	0.0074
Brugia malayi	histone deacetylase 1 (HD1)	0.0388	0.0186	0.0186
Schistosoma mansoni	histone deacetylase 4 5	0.0355	0.0158	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0136	0.0136
Toxoplasma gondii	AtPH1 family protein	0.0328	0.0136	0.014
Echinococcus multilocularis	histone deacetylase	0.0355	0.0158	0.0237
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.774	0.6414	1
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0328	0.0136	0.0203
Entamoeba histolytica	hypothetical protein	0.0414	0.0209	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0452	0.0241	0.0241
Trichomonas vaginalis	centaurin/arf, putative	0.0328	0.0136	0.0054
Echinococcus multilocularis	serine:threonine protein kinase N2	0.3991	0.3238	0.4838
Brugia malayi	Uncoordinated protein 104	0.0328	0.0136	0.0136
Onchocerca volvulus	Bile acid receptor homolog	0.0452	0.0241	1
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0328	0.0136	0.0000000012005
Schistosoma mansoni	serine/threonine protein kinase	0.3991	0.3238	0.4838
Echinococcus multilocularis	serine:threonine protein kinase N2	0.3991	0.3238	0.4838
Leishmania major	histone deacetylase, putative	0.0355	0.0158	0.3117
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.3991	0.3238	0.4838
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0452	0.0241	0.0241
Trypanosoma cruzi	histone deacetylase 1, putative	0.0388	0.0186	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0136	0.0054
Schistosoma mansoni	zinc finger protein	0.0213	0.0038	0.0057
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0452	0.0241	0.0241
Trichomonas vaginalis	centaurin/arf, putative	0.0328	0.0136	0.0054
Brugia malayi	hypothetical protein	0.0239	0.006	0.006
Brugia malayi	Variant SH3 domain containing protein	0.0328	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Leishmania major	protein kinase, putative	0.0414	0.0209	1
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0328	0.0136	0.0054
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0239	0.006	0.009
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0414	0.0209	0.0312
Trichomonas vaginalis	protein transport protein sec7, putative	0.0328	0.0136	0.0054
Brugia malayi	Dynamin	0.0328	0.0136	0.0136
Leishmania major	serine/threonine-protein kinase a, putative	0.0414	0.0209	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0213	0.0038	0.0057
Leishmania major	protein kinase, putative	0.0414	0.0209	1
Brugia malayi	p70 ribosomal S6 kinase beta	1.1645	0.9722	0.9722
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.3991	0.3238	0.3238
Brugia malayi	Protein kinase domain containing protein	0.3991	0.3238	0.3238
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0414	0.0209	0.0128
Toxoplasma gondii	Oxysterol-binding protein	0.0328	0.0136	0.014
Entamoeba histolytica	PH domain containing protein kinase, putative	0.8069	0.6693	0.6647
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0414	0.0209	0.0312
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0239	0.006	0.009
Trichomonas vaginalis	AGC family protein kinase	1.1973	1	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0328	0.0136	0.0203
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0414	0.0209	0.0116
Echinococcus multilocularis	protein kinase c epsilon type	0.3991	0.3238	0.4838
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0414	0.0209	0.0312
Echinococcus granulosus	cytohesin 1	0.0328	0.0136	0.0203
Brugia malayi	Steroid receptor seven-up type 2	0.0452	0.0241	0.0241
Echinococcus granulosus	GRB2 associated binding protein 3	0.0328	0.0136	0.0203

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 1000 ng ml-1	Inhibitory concentration against P. falciparum in mice	ChEMBL.	14613312
IC50 (binding)	= 15 nM	Inhibitory concentration against human Histone deacetylase in Hela cells	ChEMBL.	14613312
IC50 (binding)	= 30 nM	Inhibitory concentration determined against Histone deacetylase from E. tenella	ChEMBL.	14613312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 346214

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 255070