Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0224 | 0.2922 | 0.5 |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 0.2922 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0224 | 0.2922 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0224 | 0.2922 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0224 | 0.2922 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0224 | 0.2922 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0224 | 0.2922 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0224 | 0.2922 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Schistosoma mansoni | pol-related | 0.0224 | 0.2922 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0224 | 0.2922 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0224 | 0.2922 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0224 | 0.2922 | 0.5 |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 0.2922 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0224 | 0.2922 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Onchocerca volvulus | 0.0224 | 0.2922 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0381 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 0.2922 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0224 | 0.2922 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 0.2922 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0224 | 0.2922 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0224 | 0.2922 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 0.2922 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0224 | 0.2922 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 21 mg kg-1 | Inhibition of irritant electrically-induced coughing in guinea pig trachea following p.o. administration. | ChEMBL. | 7853344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.