Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 564 aa | 29.4 % | |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 562 aa | 25.1 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 480 aa | 24.6 % |
Echinococcus granulosus | neuroligin | Acetylcholinesterase | 586 aa | 493 aa | 21.5 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 586 aa | 551 aa | 40.7 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 546 aa | 29.3 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 586 aa | 535 aa | 31.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 571 aa | 25.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 586 aa | 588 aa | 28.1 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 612 aa | 25.5 % | |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 586 aa | 474 aa | 31.6 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 586 aa | 552 aa | 37.7 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 586 aa | 602 aa | 24.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 586 aa | 643 aa | 32.2 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Acetylcholinesterase | 586 aa | 577 aa | 33.6 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 586 aa | 487 aa | 23.0 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 509 aa | 24.8 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 586 aa | 648 aa | 32.6 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 592 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0298 | 1 | 1 | |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0229 | 0.6544 | 0.6544 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0229 | 0.6544 | 0.6544 |
Onchocerca volvulus | Putative nachr subunit | 0.0229 | 0.6544 | 0.6544 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.9435 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0229 | 0.6544 | 0.6936 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 0.9435 | 0.9435 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.9435 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0229 | 0.6544 | 0.6936 |
Onchocerca volvulus | 0.0298 | 1 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 0.9435 | 0.9435 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 0.9435 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0298 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 0.9435 | 0.9435 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.9435 | 0.9435 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.9435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7968 | 0.7968 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0229 | 0.6544 | 0.6936 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.9435 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.9435 | 0.9435 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0229 | 0.6544 | 0.6936 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0229 | 0.6544 | 0.6936 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 1 | 1 |
Onchocerca volvulus | 0.0298 | 1 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 0.9435 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0229 | 0.6544 | 0.6936 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.9435 | 0.9435 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.9435 | 0.9435 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.6544 | 0.6544 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.63 uM | In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 4.63 uM | In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 50.6 uM | In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 50.6 uM | In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 3.25 uM | In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 3.25 uM | In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 9.05 uM | In vitro binding affinity was determined against acetylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 9.05 uM | In vitro binding affinity was determined against acetylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.