Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0654 | 1 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0654 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0654 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0654 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0153 | 0.0153 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0153 | 0.0153 |
Schistosoma mansoni | tyrosine kinase | 0.0122 | 0.1288 | 0.1288 |
Echinococcus granulosus | thymidylate synthase | 0.0654 | 1 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0122 | 0.1288 | 0.1259 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0122 | 0.1288 | 0.1288 |
Echinococcus granulosus | twitchin | 0.0046 | 0.0033 | 0.0033 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0214 | 0.2787 | 0.1574 |
Brugia malayi | hypothetical protein | 0.0311 | 0.438 | 0.3435 |
Echinococcus granulosus | neuroglian | 0.0046 | 0.0033 | 0.0033 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0053 | 0.0153 | 0.0153 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0122 | 0.1288 | 0.1288 |
Loa Loa (eye worm) | TK protein kinase | 0.0132 | 0.1441 | 0.1441 |
Echinococcus multilocularis | roundabout 2 | 0.0053 | 0.0153 | 0.0121 |
Schistosoma mansoni | nephrin | 0.0046 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0214 | 0.2787 | 0.2787 |
Loa Loa (eye worm) | thymidylate synthase | 0.0654 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0654 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0654 | 1 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0179 | 0.2221 | 0.026 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0311 | 0.438 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0654 | 1 | 1 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0122 | 0.1288 | 0.1259 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | Inhibitory activity against Vascular endothelial growth factor receptor 2 | ChEMBL. | 10602697 |
IC50 (binding) | = 0.24 uM | Inhibitory activity against Vascular endothelial growth factor receptor 2 | ChEMBL. | 10602697 |
IC50 (binding) | = 0.77 uM | Inhibitory activity against Fibroblast growth factor receptor 1 | ChEMBL. | 10602697 |
IC50 (binding) | = 0.77 uM | Inhibitory activity against Fibroblast growth factor receptor 1 | ChEMBL. | 10602697 |
IC50 (binding) | = 4.19 uM | Inhibitory activity against Platelet-derived growth factor receptor beta | ChEMBL. | 10602697 |
IC50 (binding) | = 4.19 uM | Inhibitory activity against Platelet-derived growth factor receptor beta | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against VEGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against FGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against PDGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity against ligand-dependent EGF cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against VEGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against FGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity of compound against PDGF induced cell proliferation | ChEMBL. | 10602697 |
IC50 (functional) | > 50 uM | Inhibitory activity against ligand-dependent EGF cell proliferation | ChEMBL. | 10602697 |
IC50 (binding) | > 100 uM | Inhibitory activity against Epidermal growth factor receptor | ChEMBL. | 10602697 |
IC50 (binding) | > 100 uM | Inhibitory activity against Epidermal growth factor receptor | ChEMBL. | 10602697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.