Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.0281 | 0.1995 | 0.1995 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1042 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1042 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0281 | 0.1995 | 0.1995 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1042 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0281 | 0.1995 | 0.1995 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1042 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1042 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1042 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1042 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1042 | 1 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0281 | 0.1995 | 0.1995 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1042 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0281 | 0.1995 | 0.1995 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1042 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0645 | 0.5821 | 0.5821 |
Plasmodium falciparum | adenosine deaminase | 0.0281 | 0.1995 | 0.1995 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0327 | 0.2478 | 0.0603 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1042 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1042 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0281 | 0.1995 | 0.1995 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0645 | 0.5821 | 0.5821 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1042 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0281 | 0.1995 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0281 | 0.1995 | 0.1995 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1042 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1042 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1031 | 0.1031 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0645 | 0.5821 | 0.5821 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1031 | 0.1031 |
Echinococcus multilocularis | adenosine deaminase | 0.0281 | 0.1995 | 0.1995 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0645 | 0.5821 | 0.5821 |
Schistosoma mansoni | adenosine deaminase | 0.0281 | 0.1995 | 0.1995 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1995 | 0.1995 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1031 | 0.1031 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0281 | 0.1995 | 0.1995 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1031 | 0.1031 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1042 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0281 | 0.1995 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0281 | 0.1995 | 0.1995 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1042 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1042 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = -7.2 | -log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836622 |
EC50 (functional) | = -6.64 | in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator assay | ChEMBL. | 9836622 |
Ki (binding) | = -7.87 | Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) | ChEMBL. | 9836622 |
Log EC50 (functional) | = 6.64 | in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator assay | ChEMBL. | 9836622 |
Log EC50 (functional) | = 7.2 | -log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836622 |
Log Ki (binding) | = 7.87 | Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) | ChEMBL. | 9836622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.