Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 194 ug kg-1 | Beta agonist activity against heart rate in rats | ChEMBL. | 6142955 |
ED30 (functional) | = 194 ug kg-1 | Beta agonist activity against heart rate in rats | ChEMBL. | 6142955 |
ED50 (functional) | = 24 ug kg-1 | Inhibition of isoprenaline induced tachycardia in anaesthetised rats. | ChEMBL. | 6142955 |
ED50 (functional) | = 24 ug kg-1 | Inhibition of isoprenaline induced tachycardia in anaesthetised rats. | ChEMBL. | 6142955 |
ED50 (functional) | = 523 ug kg-1 | Beta-2 adrenergic receptor antagonism in rats anesthetized with pentobarbitone sodium (75 mg/kg ip) | ChEMBL. | 6142955 |
ED50 (functional) | = 523 ug kg-1 | Beta-2 adrenergic receptor antagonism in rats anesthetized with pentobarbitone sodium (75 mg/kg ip) | ChEMBL. | 6142955 |
pKa (ADMET) | < 0.6 | Acid dissociation constant of the compound was determined | ChEMBL. | 6142955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.