Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0145 | 0.3312 | 0.328 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.3312 | 0.328 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.1093 | 0.2353 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0181 | 0.4488 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.1065 | 0.1022 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0181 | 0.4488 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0181 | 0.4488 | 0.4461 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.1093 | 0.2353 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.1065 | 0.1022 |
Leishmania major | 0.0181 | 0.4488 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0046 | 0.0048 | 0.0107 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0181 | 0.4488 | 0.4461 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0181 | 0.4488 | 0.4461 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.1093 | 0.2435 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0046 | 0.0048 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.1093 | 0.105 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0145 | 0.3312 | 0.7381 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.1093 | 0.105 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0181 | 0.4488 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0181 | 0.4488 | 1 |
Onchocerca volvulus | 0.0347 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.1065 | 0.1022 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0181 | 0.4488 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0181 | 0.4488 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0145 | 0.3312 | 0.7352 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0145 | 0.3312 | 0.328 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 5000 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.