Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Cryptosporidium hominis | chain A, crystal structure of Dhfr | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Cryptosporidium parvum | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 181 aa | 174 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AStacin protease | 0.0061 | 0.0845 | 0.0845 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3372 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1687 | 0.1687 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0097 | 0.1789 | 0.1721 |
Brugia malayi | Fibulin-1 precursor | 0.0031 | 0.0082 | 0.0082 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0296 | 0.0296 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0097 | 0.1789 | 0.1789 |
Echinococcus granulosus | Tolloid protein 1 | 0.0097 | 0.1789 | 0.1721 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0082 | 0.0082 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3372 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3372 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.3372 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0031 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0031 | 0.0082 | 0.0082 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3372 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0097 | 0.1789 | 0.1789 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity scale (binding) | > 100 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | > 100 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | > 1000 nM | Antimycobacterial activity scale was evaluated and found to be inactive against human Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | > 1000 nM | Antimycobacterial activity scale was evaluated and found to be inactive against human Dihydrofolate reductase | ChEMBL. | 11754578 |
IC50 (binding) | = 280 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 280 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 3400 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 3400 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.