Detailed information for compound 256877

Basic information

Technical information
  • TDR Targets ID: 256877
  • Name: N-[(E)-3-(2-amino-1H-imidazol-5-yl)prop-2-eny l]-4,5-dibromo-1H-pyrrole-2-carboxamide
  • MW: 389.046 | Formula: C11H11Br2N5O
  • H donors: 4 H acceptors: 2 LogP: 2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc([nH]1)/C=C/CNC(=O)c1[nH]c(c(c1)Br)Br
  • InChi: 1S/C11H11Br2N5O/c12-7-4-8(18-9(7)13)10(19)15-3-1-2-6-5-16-11(14)17-6/h1-2,4-5,18H,3H2,(H,15,19)(H3,14,16,17)/b2-1+
  • InChiKey: QKJAXHBFQSBDAR-OWOJBTEDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(E)-3-(2-amino-1H-imidazol-5-yl)allyl]-4,5-dibromo-1H-pyrrole-2-carboxamide
  • N-[(E)-3-(2-azanyl-1H-imidazol-5-yl)prop-2-enyl]-4,5-dibromo-1H-pyrrole-2-carboxamide
  • oroidin
  • N-[(E)-3-(2-amino-3H-imidazol-4-yl)prop-2-enyl]-4,5-dibromo-1H-pyrrole-2-carboxamide
  • N-[3-(2-amino-3H-imidazol-4-yl)prop-2-enyl]-4,5-dibromo-1H-pyrrole-2-carboxamide
  • 34649-22-4
  • 1H-Pyrrole-2-carboxamide, N-(3-(2-amino-1H-imidazol-4-yl)-2-propenyl)-4,5-dibromo-, (E)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase References
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase kinase 1 Starlite/ChEMBL References
Plasmodium falciparum enoyl-acyl carrier reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) Get druggable targets OG5_127304 All targets in OG5_127304
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana protein kinase, putative,mitogen activated protein kinase, putative Get druggable targets OG5_127304 All targets in OG5_127304
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Trypanosoma brucei gambiense protein kinase, putative,MAP kinase kinase, putative Get druggable targets OG5_127304 All targets in OG5_127304
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus dual specificity mitogen activated protein Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Candida albicans likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma brucei mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania braziliensis mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Cryptosporidium hominis protein kinase NPK2 (EC 2.7.1.-) Get druggable targets OG5_127304 All targets in OG5_127304
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 Get druggable targets OG5_127304 All targets in OG5_127304
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum protein kinase NPK2 Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Schistosoma japonicum Dual specificity mitogen-activated protein kinase kinase 1, putative Get druggable targets OG5_127304 All targets in OG5_127304
Giardia lamblia Kinase, STE STE20 Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma congolense mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus multilocularis dual specificity mitogen activated protein Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans member of the HOG1 MAPK cascade Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Leishmania infantum mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Schistosoma japonicum Dual specificity mitogen-activated protein kinase kinase 2, putative Get druggable targets OG5_127304 All targets in OG5_127304
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.009 0.3046 1
Onchocerca volvulus 0.0015 0 0.5
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.009 0.3046 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.8452 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1905 0.6255
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0015 0 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1905 0.6255
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.8452 1
Echinococcus multilocularis dual specificity mitogen activated protein 0.009 0.3046 0.3046
Schistosoma mansoni serine/threonine protein kinase 0.0262 1 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.5404 0.5432
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1905 0.1915
Brugia malayi Raf kinase 0.0253 0.963 1
Onchocerca volvulus 0.0015 0 0.5
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.8452 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.8452 1
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1905 0.1905
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.8452 1
Echinococcus granulosus dual specificity mitogen activated protein 0.009 0.3046 0.3046
Trichomonas vaginalis STE family protein kinase 0.009 0.3046 0.1742
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1905 0.1905
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1905 0.2254
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1905 0.6255
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.8452 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1905 0.1905
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1905 0.6255
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1905 0.6255
Trichomonas vaginalis hypothetical protein 0.0223 0.8452 1
Trichomonas vaginalis STE family protein kinase 0.009 0.3046 0.1742
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.009 0.3046 0.3061
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.009 0.3046 0.3163
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.009 0.3046 1
Trypanosoma brucei protein kinase, putative 0.0062 0.1905 0.6255
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1905 0.6255
Brugia malayi MAP kinase sur-1 0.0062 0.1905 0.1978
Schistosoma mansoni protein kinase 0.009 0.3046 0.3046
Giardia lamblia Kinase, STE STE20 0.009 0.3046 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1905 0.6255
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.8452 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1905 0.1905
Loa Loa (eye worm) raf kinase 0.026 0.9948 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.8452 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1905 0.1905
Trichomonas vaginalis STE family protein kinase 0.009 0.3046 0.1742

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antifungal activity against Cryptococcus neoformans ChEMBL. 17190452
Activity (functional) Antileishmanial activity against Leishmania donovani ChEMBL. 17190452
Activity (functional) = 35 % Induction of apoptosis in human HepG2 cells at 50 uM incubated for 24 hrs by Annexin V-FITC and propidium iodide staining based microcapillary flow cytometry ChEMBL. No reference
Activity (ADMET) = 650 uM Toxicity in Caenorhabditis elegans L4 stage larva assessed as toxicity threshold after 6 to 7 days ChEMBL. 19719234
Dry weight (functional) = 2.1 % Distribution of the compound in Carribean Agelas conifera was determined and expressed as % dry weight ChEMBL. No reference
Dry weight (functional) = 2.1 % Distribution of the compound in Carribean Agelas clathrodes was determined and expressed as % dry weight ChEMBL. No reference
Dry weight (functional) = 4.1 % Distribution of the compound in Carribean Agelas longissima was determined and expressed as % dry weight ChEMBL. No reference
Dry weight (functional) = 4.2 % Distribution of the compound in Carribean Agelas dispar was determined and expressed as % dry weight ChEMBL. No reference
GI (functional) = 30 % Antimicrobial activity against Pdrp5 overexpressing Saccharomyces cerevisiae AD124567 assessed as growth yield reduction at 200 uM after 48 hrs by chemosensitization assay ChEMBL. 21207971
GI (functional) = 30 % Antimicrobial activity against Pdrp5-deficient Saccharomyces cerevisiae AD124567 assessed as growth yield reduction at 200 uM after 48 hrs by chemosensitization assay ChEMBL. 21207971
GI50 (functional) > 50 uM Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 24508308
IC50 (functional) = 1200 ng/ml Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 17190452
IC50 (binding) > 2500 nM Inhibition of kinase activity of Raf/MEK/ERK kinase cascade in ELISA ChEMBL. 11784156
IC50 (binding) = 2500 nM Inhibition of MEK1 phosphorylation by activated human recombinant Raf ChEMBL. 11784156
IC50 (binding) > 2500 nM Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 ChEMBL. 11784156
IC50 (binding) > 2500 nM Inhibition of kinase activity of Raf/MEK/ERK kinase cascade in ELISA ChEMBL. 11784156
IC50 (binding) = 2500 nM Inhibition of MEK1 phosphorylation by activated human recombinant Raf ChEMBL. 11784156
IC50 (binding) > 2500 nM Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 ChEMBL. 11784156
IC50 (functional) > 10000 nM Inhibition of human adenocarcinoma cell line Caco-2 proliferation ChEMBL. 11784156
IC50 (functional) > 10000 nM Inhibition of human adenocarcinoma cell line LoVo proliferation ChEMBL. 11784156
IC50 (functional) > 10000 nM Inhibition of human adenocarcinoma cell line Caco-2 proliferation ChEMBL. 11784156
IC50 (functional) > 10000 nM Inhibition of human adenocarcinoma cell line LoVo proliferation ChEMBL. 11784156
IC50 (binding) = 0.3 ug ml-1 Inhibition of Plasmodium falciparum FabI ChEMBL. 17765547
IC50 (binding) = 0.3 ug ml-1 Inhibition of Plasmodium falciparum FabI ChEMBL. 17765547
IC50 (functional) = 3.9 ug ml-1 Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs ChEMBL. 17765547
IC50 (functional) = 3.9 ug ml-1 Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs ChEMBL. 17765547
IC50 (functional) = 17.3 ug ml-1 Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by Alamar blue assay ChEMBL. 17765547
IC50 (functional) = 17.3 ug ml-1 Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by Alamar blue assay ChEMBL. 17765547
IC50 (functional) > 30 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi after 72 hrs ChEMBL. 17765547
IC50 (functional) > 30 ug ml-1 Antileishmanial activity against Leishmania donovani after 72 hrs by Alamar blue assay ChEMBL. 17765547
IC50 (functional) > 30 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi after 72 hrs ChEMBL. 17765547
IC50 (functional) > 30 ug ml-1 Antileishmanial activity against Leishmania donovani after 72 hrs by Alamar blue assay ChEMBL. 17765547
IC50 (ADMET) = 88.6 ug ml-1 Cytotoxicity against rat L6 cells after 72 hrs ChEMBL. 17765547
Inhibition (functional) = 71 % Antimycobacterial activity against Mycobacterium tuberculosis at 128 ug/mL ChEMBL. 17190452
Ki (binding) = 0.4 uM Inhibition of Plasmodium falciparum FabI in presence of variable crotonyl-coA level ChEMBL. 17765547
Ki (binding) = 0.4 uM Inhibition of Plasmodium falciparum FabI in presence of variable crotonyl-coA level ChEMBL. 17765547
Ki (binding) = 0.8 uM Inhibition of Plasmodium falciparum FabI in presence of variable NADH levels ChEMBL. 17765547
Ki (binding) = 0.8 uM Inhibition of Plasmodium falciparum FabI in presence of variable NADH levels ChEMBL. 17765547
MIC (functional) Antimicrobial activity against Candida albicans after 24 hrs by microdilution method ChEMBL. 26872204
pD2 (binding) = 4.02 Apparent affinity of the compound towards histamine receptor was determined and expressed as pD2 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 17190452
Homo sapiens ChEMBL23 11784156

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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