Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Cryptosporidium parvum | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Cryptosporidium hominis | chain A, crystal structure of Dhfr | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 181 aa | 174 aa | 31.6 % |
Activity type | Activity value | Assay description | Source | Reference | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 | |||||||||||||||||||||||||
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 | |||||||||||||||||||||||||
Activity scale (binding) | > 1000 nM |
ChEMBL.
|
11754578
|
Activity scale (binding)
|
> 1000 nM
|
|
ChEMBL.
|
11754578
|
IC50 (binding)
|
= 5.3 nM
|
Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)
|
ChEMBL.
|
11754578
|
IC50 (binding)
|
= 5.3 nM
|
Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)
|
ChEMBL.
|
11754578
|
IC50 (binding)
|
= 1900 nM
|
Antimycobacterial activity against human dihydrofolate reductase (hDHFR)
|
ChEMBL.
|
11754578
|
IC50 (binding)
|
= 1900 nM
|
Antimycobacterial activity against human dihydrofolate reductase (hDHFR)
|
ChEMBL.
|
11754578
|
|
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.