Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Cryptosporidium hominis | chain A, crystal structure of Dhfr | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Cryptosporidium parvum | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 181 aa | 174 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | < 100 nM | Antimycobacterial activity scale found to be highly active against human dihydrofolate reductase. | ChEMBL. | 11754578 |
Activity scale (binding) | < 100 nM | Antimycobacterial activity scale found to be highly active against human dihydrofolate reductase. | ChEMBL. | 11754578 |
IC50 (binding) | = 0.78 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 0.78 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 33 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 33 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.