TDR Targets

Basic information

Technical information

TDR Targets ID: 257087
Name: 3-(4-hydroxyphenyl)propyl 3,5-dihydroxy-4-(2- hydroxy-6-methoxycarbonylbenzoyl)benzoate
MW: 466.437 | Formula: C25H22O9
H donors: 4 H acceptors: 7 LogP: 4.41 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1cccc(c1C(=O)c1c(O)cc(cc1O)C(=O)OCCCc1ccc(cc1)O)O
InChi: 1S/C25H22O9/c1-33-25(32)17-5-2-6-18(27)21(17)23(30)22-19(28)12-15(13-20(22)29)24(31)34-11-3-4-14-7-9-16(26)10-8-14/h2,5-10,12-13,26-29H,3-4,11H2,1H3
InChiKey: PEHFMYWGWHPKOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(4-hydroxyphenyl)propyl 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonyl-benzoyl)benzoate
3,5-dihydroxy-4-[(2-hydroxy-6-methoxycarbonylphenyl)-oxomethyl]benzoic acid 3-(4-hydroxyphenyl)propyl ester
3-(4-hydroxyphenyl)propyl 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonyl-phenyl)carbonyl-benzoate
4-(2-carbomethoxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 3-(4-hydroxyphenyl)propyl ester
Acyclic Balanol Analog 21c

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, eta	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, alpha		References
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, beta		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium berghei	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Theileria parva	cAMP-dependent protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania major	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	protein kinase A catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase DC2, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania braziliensis	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania donovani	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma congolense	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania mexicana	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium knowlesi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Theileria parva	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Cryptosporidium hominis	protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Leishmania braziliensis	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Cryptosporidium parvum	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	protein kinase, cAMP-dependent, catalytic, beta	358 aa	320 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0066	0.0156	0.0155
Echinococcus granulosus	carboxylesterase 5A	0.3462	1	1
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0147	0.0391	1
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0025	0.0025
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0066	0.0156	0.0156
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0019	0.0014
Echinococcus multilocularis	protein kinase c epsilon type	0.0286	0.0793	0.0793
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0066	0.0156	0.0155
Echinococcus granulosus	serine:threonine protein kinase N2	0.017	0.0456	0.0456
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0009	0.0227
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0009	0.0227
Entamoeba histolytica	protein kinase, putative	0.0066	0.0156	0.173
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.005	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Echinococcus granulosus	lamin	0.0027	0.0042	0.0041
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0019	0.0019
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.0648	0.3904
Treponema pallidum	fructose-bisphosphate aldolase	0.0291	0.0808	0.5
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0096	0.0096
Echinococcus granulosus	Protein kinase C brain isozyme	0.0262	0.0724	0.0724
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0046	0.0096	0.0096
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0046	0.0096	0.0087
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0019	0.001
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0262	0.0724	0.0724
Brugia malayi	Ras association domain family 1 isoform A	0.0046	0.0096	0.0091
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0	0.5
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0049	0.0105	0.0099
Echinococcus granulosus	para nitrobenzyl esterase	0.0585	0.166	0.1659
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.0391	0.0391
Echinococcus granulosus	BC026374 protein S09 family	0.0585	0.166	0.1659
Schistosoma mansoni	rac gtpase activating protein	0.0046	0.0096	0.0087
Echinococcus multilocularis	protein kinase c iota type	0.0112	0.0288	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Onchocerca volvulus		0.0036	0.0068	0.0407
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0188	0.051	0.051
Schistosoma mansoni	hypothetical protein	0.0169	0.0453	0.0444
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0139	0.013
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0585	0.166	1
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0144	0.0382	0.0382
Entamoeba histolytica	protein kinase, putative	0.0066	0.0156	0.173
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.3462	1	1
Mycobacterium ulcerans	glutaminase	0.0272	0.0754	0.4308
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0049	0.0105	0.0105
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0042	0.0042
Leishmania major	protein kinase, putative	0.0016	0.0009	0.0227
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0066	0.0156	0.0155
Echinococcus granulosus	intermediate filament protein	0.0027	0.0042	0.0041
Echinococcus multilocularis	para nitrobenzyl esterase	0.0585	0.166	0.1659
Echinococcus multilocularis	acetylcholinesterase	0.3462	1	1
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Loa Loa (eye worm)	glutaminase	0.0272	0.0754	0.0754
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0066	0.0156	0.0156
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0009	0.0234
Brugia malayi	Carboxylesterase family protein	0.0585	0.166	0.1655
Echinococcus granulosus	serine:threonine protein kinase N2	0.0066	0.0156	0.0155
Schistosoma mansoni	protein kinase C mu	0.0049	0.0105	0.0096
Schistosoma mansoni	protein kinase C mu	0.0046	0.0096	0.0087
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0028	0.0019
Brugia malayi	hypothetical protein	0.0585	0.166	0.1655
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0009
Schistosoma mansoni	vav2	0.0046	0.0096	0.0087
Echinococcus multilocularis	carboxylesterase 5A	0.3462	1	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0139	0.3479
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0147	0.0391	1
Echinococcus multilocularis	N chimaerin	0.0046	0.0096	0.0096
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0025	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.005	0.005
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0147	0.0391	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.005	0.1168
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0147	0.0391	1
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0156	0.015
Schistosoma mansoni	lamin	0.0027	0.0042	0.0032
Brugia malayi	hypoxia-induced factor 1	0.015	0.0399	0.0393
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0019	0.0019
Brugia malayi	RhoGAP domain containing protein	0.0046	0.0096	0.0091
Echinococcus granulosus	unc 13 munc13	0.0053	0.0118	0.0118
Loa Loa (eye worm)	raf kinase	0.0046	0.0096	0.0096
Brugia malayi	Carboxylesterase family protein	0.0585	0.166	0.1655
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0156	0.015
Brugia malayi	Pre-SET motif family protein	0.003	0.005	0.0045
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0009	0.0009
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0009	0.0227
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.0391	0.2353
Loa Loa (eye worm)	carboxylesterase	0.0585	0.166	0.166
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0147	0.0391	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Trichomonas vaginalis	glutaminase, putative	0.0272	0.0754	0.4539
Leishmania major	protein kinase, putative	0.0016	0.0009	0.0227
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0019	0.0019
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.005	0.005
Toxoplasma gondii	AGC kinase	0.0147	0.0391	1
Brugia malayi	intermediate filament protein	0.0027	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0096	0.0091
Leishmania major	protein kinase A catalytic subunit	0.0147	0.0391	1
Entamoeba histolytica	protein kinase, putative	0.0066	0.0156	0.173
Echinococcus granulosus	neuroligin	0.0585	0.166	0.1659
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.0391	0.0382
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0046	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0066	0.0156	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Brugia malayi	RhoGAP domain containing protein	0.0046	0.0096	0.0091
Brugia malayi	C1-like domain containing protein	0.0049	0.0105	0.0099
Onchocerca volvulus		0.0027	0.0042	0.0249
Brugia malayi	Carboxylesterase family protein	0.3462	1	1
Schistosoma mansoni	glutaminase	0.0272	0.0754	0.0745
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0156	0.0146
Schistosoma mansoni	unc-13 (munc13)	0.0053	0.0118	0.0109
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0013	0.0003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Toxoplasma gondii	AGC kinase	0.0066	0.0156	0.3906
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0009	0.0004
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0046	0.0096	0.0096
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0019	0.001
Onchocerca volvulus		0.0236	0.0648	0.3904
Schistosoma mansoni	unc-13 (munc13)	0.0055	0.0124	0.0114
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0147	0.0391	1
Brugia malayi	Carboxylesterase family protein	0.0585	0.166	0.1655
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0096	0.0096
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0019	0.0019
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0019	0.0019
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0585	0.166	0.1659
Brugia malayi	protein kinase C3,putative	0.0049	0.0105	0.0099
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0018	0.0223
Entamoeba histolytica	diacylglycerol kinase, putative	0.0046	0.0096	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0019	0.0019
Echinococcus granulosus	N chimaerin	0.0046	0.0096	0.0096
Brugia malayi	Protein kinase c protein 2	0.0199	0.0541	0.0536
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0009
Onchocerca volvulus		0.0053	0.0118	0.0709
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0066	0.0156	0.0156
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0009
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0147	0.0391	1
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0156	0.0146
Brugia malayi	Carboxylesterase family protein	0.0585	0.166	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0447	0.0447
Toxoplasma gondii	diacylglycerol kinase, putative	0.0046	0.0096	0.236
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0019	0.0019
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0019	0.001
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0142	0.0376	0.2223
Echinococcus granulosus	single minded 2	0.0036	0.0068	0.0067
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0066	0.0156	0.0155
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0142	0.0376	1
Onchocerca volvulus		0.0585	0.166	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0139	0.0449
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.3462	1	1
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Brugia malayi	diacylglycerol kinase	0.0046	0.0096	0.0091
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0139	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0233	0.0639	0.0639
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0025	0.002
Schistosoma mansoni	atypical protein kinase C	0.0112	0.0288	0.0279
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0049	0.0105	0.0105
Echinococcus multilocularis	neuroligin	0.0585	0.166	0.1659
Echinococcus multilocularis	geminin	0.0169	0.0453	0.0453
Onchocerca volvulus		0.003	0.005	0.03
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0019	0.0019
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0144	0.0382	0.0382
Schistosoma mansoni	acetylcholinesterase	0.0585	0.166	0.1652
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Schistosoma mansoni	serine/threonine kinase	0.0066	0.0156	0.0146
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0022	0.0028	0.0028
Brugia malayi	diacylglycerol kinase	0.0046	0.0096	0.0091
Echinococcus multilocularis	protein kinase c eta type	0.0046	0.0096	0.0096
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0019	0.0019
Echinococcus granulosus	NDR protein kinase	0.0066	0.0156	0.0155
Brugia malayi	glutaminase DH11.1	0.0272	0.0754	0.0748
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.0378	0.0378
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0019	0.001
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0066	0.0156	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0585	0.166	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0022	0.0028	0.0023
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0009	0.0009
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0068	0.0067
Mycobacterium ulcerans	carboxylesterase, LipT	0.0585	0.166	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0009	0.0234
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0025	0.0025
Schistosoma mansoni	lamin	0.0027	0.0042	0.0032
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0019	0.0014
Brugia malayi	Pre-SET motif family protein	0.0207	0.0565	0.056
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0046	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.3462	1	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0053	0.0118	0.0118
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0001	0.0001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0014
Onchocerca volvulus		0.0585	0.166	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0046	0.0096	0.0974
Echinococcus granulosus	geminin	0.0169	0.0453	0.0453
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0233	0.0639	0.0639
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0046	0.0096	0.0096
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0286	0.0793	0.0793
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0046	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.003	0.005	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0163	0.0435	0.043
Echinococcus granulosus	Diacylglycerol kinase theta	0.0046	0.0096	0.0096
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.0156	0.0156
Trichomonas vaginalis	spcc417.12 protein, putative	0.0585	0.166	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0585	0.166	0.1659
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0009	0.0004
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.0378	0.0378
Toxoplasma gondii	AGC kinase	0.0147	0.0391	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0046	0.0096	0.0087
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Schistosoma mansoni	hypothetical protein	0.0052	0.0113	0.0104
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0019	0.001
Brugia malayi	PXA domain containing protein	0.0019	0.0019	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0042
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0139	0.3557
Loa Loa (eye worm)	acetylcholinesterase 1	0.3462	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0139	0.013
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0585	0.166	0.1652
Echinococcus granulosus	acetylcholinesterase	0.3462	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0585	0.166	0.1652
Onchocerca volvulus		0.0585	0.166	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0066	0.0156	0.0156
Brugia malayi	Hr1 repeat family protein	0.0066	0.0156	0.015
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0019	0.001
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0046	0.0096	0.0087
Echinococcus granulosus	raf serine:threonine protein kinase	0.0046	0.0096	0.0096
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0066	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0019	0.0019
Echinococcus multilocularis	expressed protein	0.0372	0.1042	0.1042
Echinococcus multilocularis	unc 13 (munc13)	0.0053	0.0118	0.0118
Echinococcus granulosus	protein kinase C gamma type	0.0217	0.0592	0.0592
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0009	0.0115
Brugia malayi	RhoGEF domain containing protein	0.0046	0.0096	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	lamin dm0	0.0027	0.0042	0.0041
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0019	0.0014
Echinococcus granulosus	protein kinase c iota type	0.0112	0.0288	0.0288
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0019	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0028	0.0019
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0153	0.0409	0.0409
Schistosoma mansoni	diacylglycerol kinase theta	0.0046	0.0096	0.0087
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0063	0.0147	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0585	0.166	1
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0019	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Brugia malayi	PAS domain containing protein	0.0048	0.0104	0.0099
Echinococcus granulosus	lamin dm0	0.0027	0.0042	0.0041
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0147	0.0391	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0001	0.0001
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0019	0.001
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0147	0.0391	0.0385
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0104	0.0095
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0585	0.166	0.1652
Echinococcus multilocularis	lamin	0.0027	0.0042	0.0041
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0046	0.0096	0.0096
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0066	0.0156	0.3835
Schistosoma mansoni	BC026374 protein (S09 family)	0.0585	0.166	0.1652
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0156	0.0936
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0022	0.0028	0.0028
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0049	0.0105	0.0105
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.0808	1
Schistosoma mansoni	protein kinase C	0.0053	0.0118	0.0109
Echinococcus granulosus	Rac GTPase activating protein 1	0.0046	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.0391	0.0382
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.0391	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0142	0.0376	0.1938
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.0391	0.0382
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0066	0.0156	0.0155
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0026	0.004	0.004
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0019	0.0114
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0019	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.005	0.0041
Plasmodium vivax	SET domain protein, putative	0.003	0.005	0.1156
Schistosoma mansoni	diacylglycerol kinase theta	0.0046	0.0096	0.0087
Onchocerca volvulus		0.0167	0.0447	0.2692
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0579	0.0579
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0042	0.0032
Brugia malayi	protein kinase C II.	0.0286	0.0793	0.0788
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0019	0.0019
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0047	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.005	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0001
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.0028	0.0028
Echinococcus granulosus	protein kinase c epsilon type	0.0286	0.0793	0.0793
Onchocerca volvulus		0.0585	0.166	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0147	0.0391	0.4711
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0139	0.0449
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0585	0.166	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.015	0.0399	0.0399
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0147	0.0391	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.005	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0585	0.166	0.166
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0118	0.0118
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0009	0.0227
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0105	0.0096
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0025	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0156	0.015
Entamoeba histolytica	hypothetical protein	0.0046	0.0096	0.0974
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0009	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0009
Onchocerca volvulus		0.0585	0.166	1
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0096	0.0091
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0019	0.0014
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0019	0.0014
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0019	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.0724	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0042	0.0042
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0585	0.166	0.1652
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0019	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0096	0.0087
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0139	0.0139
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.0378	0.0378
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0066	0.0156	0.0155
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0019	0.001
Giardia lamblia	Fructose-bisphosphate aldolase	0.0291	0.0808	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0009	0.0009
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0585	0.166	0.1659
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0139	0.0786
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.0565	0.0565
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.0808	1
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0105	0.0099
Loa Loa (eye worm)	carboxylesterase	0.3462	1	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0009	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Entamoeba histolytica	protein kinase, putative	0.0066	0.0156	0.173
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0808	0.4869
Echinococcus granulosus	expressed protein	0.0372	0.1042	0.1042
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0068	0.0062
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.0724	0.0715
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0147	0.0391	0.4711
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0019	0.0114
Echinococcus multilocularis	serine threonine protein kinase	0.0217	0.0592	0.0592
Onchocerca volvulus		0.0046	0.0096	0.0577
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0046	0.0096	0.0096
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0147	0.0391	1
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0049	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0447	0.0447
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0028	0.0019
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0435	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0053	0.0118	0.0118
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.0391	0.0391
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0096	0.0096
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0156	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0378	0.0378
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.005	0.0041
Brugia malayi	p70 ribosomal S6 kinase beta	0.0066	0.0156	0.015
Echinococcus multilocularis	musashi	0.0027	0.0042	0.0041
Onchocerca volvulus		0.0027	0.0042	0.0249
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0139	0.0139
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0025	0.0151
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0066	0.0156	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0156	0.0146
Echinococcus multilocularis	acetylcholinesterase	0.3462	1	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0019	0.0019
Entamoeba histolytica	PH domain containing protein kinase, putative	0.017	0.0456	0.5535
Loa Loa (eye worm)	carboxylesterase	0.0585	0.166	0.166
Echinococcus granulosus	acetylcholinesterase	0.3462	1	1
Echinococcus granulosus	protein kinase c eta type	0.0046	0.0096	0.0096
Onchocerca volvulus		0.0046	0.0096	0.0577
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0009	0.0103
Brugia malayi	PXA domain containing protein	0.0019	0.0019	0.0014
Schistosoma mansoni	single-minded	0.0048	0.0104	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0096
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Schistosoma mansoni	gliotactin	0.0585	0.166	0.1652
Schistosoma mansoni	serine/threonine protein kinase	0.0286	0.0793	0.0784
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0105	0.0096
Loa Loa (eye worm)	glutaminase 2	0.0272	0.0754	0.0754
Schistosoma mansoni	hypothetical protein	0.0169	0.0453	0.0444

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0 uM	Evaluated against recombinant human Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (binding)	= 0.17 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.17 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.3 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.3 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.46 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.46 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.75 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 0.75 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 1.3 uM	Inhibition of Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (binding)	= 1.3 uM	Inhibition of Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (binding)	= 4.1 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	= 4.1 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	= 7.8 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 7.8 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 13 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850
IC50 (binding)	= 13 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL149313
PubChem: 5327963

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 257087