Detailed information for compound 257121

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.613 | Formula: C28H30N2O5S
  • H donors: 2 H acceptors: 2 LogP: 3.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSc1ccc2c(cc1=O)[C@@H](CCc1c2c(OC)c(c(c1)OC)OC)NC(=O)C(c1ccccc1)N
  • InChi: 1S/C28H30N2O5S/c1-33-22-14-17-10-12-20(30-28(32)25(29)16-8-6-5-7-9-16)19-15-21(31)23(36-4)13-11-18(19)24(17)27(35-3)26(22)34-2/h5-9,11,13-15,20,25H,10,12,29H2,1-4H3,(H,30,32)/t20-,25?/m0/s1
  • InChiKey: DCDXTMCBYGXOBW-JINQPTGOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0013 0.0049 0.0048
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0016 0.0088 0.0087
Leishmania major hypothetical protein, conserved 0.0064 0.0769 0.074
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0176 0.2375 0.2374
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0064 0.0769 0.2331
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.0769 0.0785
Brugia malayi Tachykinin-like peptides receptor 99D 0.0134 0.1779 0.1819
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Trichomonas vaginalis discs large, putative 0.0013 0.0049 0.0144
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.024 0.3292 0.3291
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0134 0.1779 0.1819
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0134 0.1779 0.1777
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.0619
Schistosoma mansoni guanylate kinase 0.0013 0.0049 0.0047
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.1751 0.1792
Brugia malayi Cell death protein 3 precursor 0.0173 0.2333 0.2387
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0016 0.0088 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0769 0.0785
Brugia malayi GnHR receptor homolog 0.0134 0.1779 0.1819
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0439 0.1328
Trichomonas vaginalis apoptosis inducing factor, putative 0.0064 0.0769 0.2331
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0493 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.0769 0.0767
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0122
Echinococcus multilocularis Protein lozenge 0.0055 0.0644 0.0643
Echinococcus granulosus lamin dm0 0.0027 0.0239 0.0237
Loa Loa (eye worm) hypothetical protein 0.0132 0.1751 0.1791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0062 0.0061
Onchocerca volvulus 0.0027 0.0239 0.0387
Echinococcus granulosus caspase 2 0.0173 0.2333 0.2332
Treponema pallidum thioredoxin reductase (trxB) 0.0064 0.0769 0.2331
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Leishmania major geranylgeranyltransferase, putative 0.0044 0.0493 0.0457
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.0769 0.0767
Schistosoma mansoni hypothetical protein 0.0064 0.0769 0.0767
Echinococcus granulosus thioredoxin glutathione reductase 0.0692 0.9769 0.9769
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi sulfakinin receptor protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0439 0.0437
Trypanosoma brucei metacaspase MCA2 0.0132 0.1751 0.1791
Echinococcus granulosus biogenic amine 5HT receptor 0.0134 0.1779 0.1777
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0123 0.037
Schistosoma mansoni caspase-3 (C14 family) 0.0276 0.3806 0.3805
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0118
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.024 0.3292 0.337
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0493 0.0503
Echinococcus granulosus caspase 8 0.0132 0.1751 0.175
Plasmodium falciparum metacaspase-like protein 0.0132 0.1751 0.1791
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0118
Trypanosoma cruzi guanylate kinase, putative 0.0013 0.0049 0.0048
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0124 0.1635 0.1633
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0176 0.238 0.2435
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0044 0.0493 0.0503
Trypanosoma cruzi metacaspase 5, putative 0.0132 0.1751 0.1791
Brugia malayi eukaryotic initiation factor 4A 0.0176 0.2375 0.243
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0013 0.0049 0.0048
Schistosoma mansoni DNA polymerase eta 0.0014 0.0062 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0297 0.0303
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0064 0.0769 0.3236
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0064 0.0769 0.0767
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1259 0.1258
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0123 0.037
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.1635 0.1672
Echinococcus multilocularis neuropeptide receptor 0.0134 0.1779 0.1777
Brugia malayi intermediate filament protein 0.0027 0.0239 0.0243
Leishmania major hypothetical protein, conserved 0.0064 0.0769 0.074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0061 0.0728 0.0727
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0176 0.2375 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0138 0.0136
Schistosoma mansoni glutamate synthase 0.0064 0.0769 0.0767
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0007
Brugia malayi glutathione reductase 0.0692 0.9769 1
Entamoeba histolytica thioredoxin reductase, putative 0.0064 0.0769 0.3236
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0134 0.1779 0.1777
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0176 0.2375 0.243
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.024 0.3292 0.337
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0064 0.0769 0.0785
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0127 0.167 0.1708
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0138 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.024 0.3292 0.337
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0134 0.1779 0.1819
Brugia malayi Serotonin receptor 0.0134 0.1779 0.1819
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0064 0.0769 0.074
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0398 0.0397
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0064 0.0769 0.0785
Echinococcus multilocularis caspase 3 0.0144 0.1912 0.1911
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0088 0.111 0.1109
Trypanosoma cruzi NADH dehydrogenase, putative 0.0064 0.0769 0.0785
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.024 0.3292 0.3291
Onchocerca volvulus 0.0134 0.1779 0.2899
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0134 0.1779 0.1777
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0138 0.0414
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0064 0.0769 0.0787
Trichomonas vaginalis glutamate synthase, putative 0.0064 0.0769 0.2331
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0127 0.167 0.5072
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0062 0.0061
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0276 0.3806 0.3805
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.0699
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0176 0.2375 0.7213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0529 0.0528
Schistosoma mansoni cell polarity protein 0.0018 0.0121 0.0119
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0064 0.0769 0.0758
Plasmodium vivax metacaspase 1, putative 0.0132 0.1751 0.1792
Echinococcus multilocularis somatostatin receptor 0.0134 0.1779 0.1777
Echinococcus granulosus neuropeptide Y receptor 0.0134 0.1779 0.1777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Plasmodium falciparum thioredoxin reductase 0.024 0.3292 0.3368
Onchocerca volvulus 0.0024 0.0205 0.0332
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0134 0.1779 0.1777
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0117 0.0118
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.024 0.3292 0.3348
Schistosoma mansoni intermediate filament proteins 0.0027 0.0239 0.0237
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.024 0.3292 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.0744
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Echinococcus multilocularis neuropeptides capa receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0046 0.052 0.0531
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0064 0.0769 0.2331
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.018 0.2429 0.2462
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0124 0.1635 0.1672
Echinococcus granulosus tm gpcr rhodopsin 0.0134 0.1779 0.1777
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0529 0.0528
Echinococcus granulosus guanylate kinase 0.0013 0.0049 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0138 0.0139
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0493 0.1493
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0176 0.2375 0.2374
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0134 0.1779 0.1777
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.024 0.3292 1
Trypanosoma cruzi metacaspase, putative 0.0132 0.1751 0.1791
Schistosoma mansoni amine GPCR 0.0134 0.1779 0.1777
Echinococcus granulosus orexin receptor type 2 0.0134 0.1779 0.1777
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0176 0.238 0.2435
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0061 0.0728 0.0745
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0209
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0044 0.0493 0.0504
Mycobacterium ulcerans flavoprotein disulfide reductase 0.024 0.3292 1
Echinococcus granulosus lamin 0.0027 0.0239 0.0237
Trypanosoma cruzi guanylate kinase, putative 0.0013 0.0049 0.0048
Schistosoma mansoni MAGUK homolog 0.0016 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0041 0.0439 0.0448
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0176 0.2375 0.3872
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0134 0.1779 0.1819
Schistosoma mansoni glutamate synthase 0.0064 0.0769 0.0767
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.0619
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0176 0.2375 0.7213
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.024 0.3292 1
Schistosoma mansoni maguk P55 subfamily member 26 0.0013 0.0049 0.0047
Echinococcus multilocularis Kelch repeat type 1 0.0098 0.1263 0.1262
Entamoeba histolytica recQ family helicase, putative 0.002 0.0138 0.058
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0062 0.0062
Echinococcus multilocularis dna polymerase eta 0.0014 0.0062 0.006
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.0744
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0728 0.0744
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0064 0.0769 0.0767
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0064 0.0769 0.0787
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.0013 0.0049 0.0018
Brugia malayi Dopamine receptor protein 1 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0209
Schistosoma mansoni opsin-like receptor 0.0134 0.1779 0.1777
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0064 0.0769 0.0785
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.024 0.3292 0.3368
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1635 0.4963
Schistosoma mansoni MAGUK homolog 0.0016 0.0088 0.0087
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0124 0.1635 0.4963
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0123 0.0122
Plasmodium vivax conserved Plasmodium protein, unknown function 0.008 0.0999 0.1022
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Treponema pallidum NADH oxidase 0.024 0.3292 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Brugia malayi RE15519p 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0061 0.0728 0.0744
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0493 0.0504
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0061 0.0728 0.0727
Schistosoma mansoni glutamate synthase 0.0064 0.0769 0.0767
Schistosoma mansoni sulfide quinone reductase 0.0064 0.0769 0.0767
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1635 0.4963
Schistosoma mansoni DNA helicase recq5 0.002 0.0138 0.0136
Echinococcus multilocularis geminin 0.0174 0.2348 0.2346
Echinococcus multilocularis G protein coupled receptor 139 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0529 0.0528
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.3292 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0064 0.0769 0.2331
Toxoplasma gondii NADPH-glutathione reductase 0.024 0.3292 0.337
Loa Loa (eye worm) neuropeptide F receptor 0.0134 0.1779 0.1819
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0048
Echinococcus multilocularis high voltage activated calcium channel beta 0.0013 0.0049 0.0047
Giardia lamblia Rab geranylgeranyltransferase 0.0044 0.0493 0.1493
Echinococcus granulosus neuropeptide receptor 0.0134 0.1779 0.1777
Echinococcus multilocularis fmrfamide receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni maguk P55 subfamily member 35 0.0016 0.0088 0.0087
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0132 0.1751 0.175
Brugia malayi G protein-coupled receptor F59B2.13 0.0134 0.1779 0.1819
Echinococcus granulosus disks large 1 0.0013 0.0049 0.0047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0155 0.0128
Echinococcus multilocularis MAGUK p55 subfamily 0.0016 0.0088 0.0087
Echinococcus multilocularis neuropeptide receptor A26 0.0134 0.1779 0.1777
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0134 0.1779 0.1777
Schistosoma mansoni amine GPCR 0.0134 0.1779 0.1777
Leishmania major NADH dehydrogenase, putative 0.0064 0.0769 0.074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0123 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0157
Echinococcus multilocularis caspase 2 0.0173 0.2333 0.2332
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0061 0.0728 0.0744
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0123 0.0125
Trichomonas vaginalis sap-102, putative 0.0013 0.0049 0.0144
Trichomonas vaginalis glutamate synthase, putative 0.0064 0.0769 0.2331
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0124 0.1635 0.1672
Echinococcus multilocularis fmrfamide receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0176 0.2375 0.243
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0061 0.0728 0.0727
Loa Loa (eye worm) hypothetical protein 0.0125 0.1642 0.1679
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0792 0.0809
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0127 0.167 0.1669
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0205 0.0179
Echinococcus granulosus somatostatin receptor 0.0134 0.1779 0.1777
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Echinococcus granulosus dna polymerase kappa 0.0041 0.0439 0.0437
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0134 0.1779 0.1777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0176 0.2375 0.243
Treponema pallidum ATP-dependent RNA helicase 0.0176 0.2375 0.7213
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0769 0.2331
Trypanosoma cruzi lanosterol synthase, putative 0.018 0.2429 0.2485
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0173 0.2333 0.2387
Plasmodium falciparum ferrodoxin reductase-like protein 0.0064 0.0769 0.0785
Echinococcus granulosus glutamate synthase 0.0064 0.0769 0.0767
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0061 0.0728 0.0727
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0048
Echinococcus granulosus high voltage activated calcium channel beta 0.0013 0.0049 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0092 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0205 0.0179
Mycobacterium ulcerans dehydrogenase 0.0064 0.0769 0.2331
Leishmania major eukaryotic initiation factor 4a, putative 0.0176 0.2375 0.2393
Echinococcus granulosus caspase 3 0.0144 0.1912 0.1911
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0205 0.0619
Echinococcus multilocularis neuropeptides capa receptor 0.0134 0.1779 0.1777
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0134 0.1779 0.1777
Brugia malayi Dopamine receptor 0.0134 0.1779 0.1819
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0044 0.0493 0.2075
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0061 0.0728 0.2208
Echinococcus multilocularis neuropeptide Y receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0134 0.1779 0.1819
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0123 0.037
Giardia lamblia Thioredoxin reductase 0.0064 0.0769 0.2331
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.0074
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0064 0.0769 0.2331
Onchocerca volvulus 0.0134 0.1779 0.2899
Onchocerca volvulus 0.0064 0.0769 0.1251
Trypanosoma cruzi lanosterol synthase, putative 0.018 0.2429 0.2485
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0064 0.0769 0.0767
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0239 0.0243
Onchocerca volvulus 0.0134 0.1779 0.2899
Schistosoma mansoni neuropeptide F-like receptor 0.0134 0.1779 0.1777
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0205 0.0619
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0064 0.0769 0.0785
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0064 0.0769 0.2331
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0769 0.2331
Schistosoma mansoni hypothetical protein 0.0134 0.1779 0.1777
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0126
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.024 0.3292 0.3336
Echinococcus granulosus 7tm_1 domain containing protein 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0438 0.6132 0.6276
Schistosoma mansoni lozenge 0.0055 0.0644 0.0643
Leishmania major lanosterol synthase, putative 0.0135 0.1793 0.1794
Echinococcus granulosus dro:myosuppressin receptor 0.0134 0.1779 0.1777
Echinococcus granulosus high voltage activated calcium channel beta 0.0013 0.0049 0.0047
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0064 0.0769 0.2331
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0062 0.0062
Mycobacterium ulcerans guanylate kinase 0.0013 0.0049 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Brugia malayi putative neuropeptide receptor 0.0134 0.1779 0.1819
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0134 0.1779 0.1777
Plasmodium falciparum metacaspase 1 0.0132 0.1751 0.1791
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0176 0.2375 0.2374
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0138 0.0141
Trypanosoma brucei guanylate kinase, putative 0.0013 0.0049 0.0048
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0064 0.0769 0.2331
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0124 0.1635 0.6882
Echinococcus multilocularis disks large 3 0.0049 0.056 0.0558
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0792 0.0764
Schistosoma mansoni growth hormone secretagogue receptor 0.0134 0.1779 0.1777
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0209
Echinococcus multilocularis dro:myosuppressin receptor 0.0134 0.1779 0.1777
Leishmania major dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3336
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus bloom syndrome protein 0.002 0.0138 0.0136
Echinococcus granulosus alpha 1A adrenergic receptor 0.0134 0.1779 0.1777
Brugia malayi G-protein coupled receptor 0.0134 0.1779 0.1819
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0064 0.0769 0.2331
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.024 0.3292 0.3368
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0092 0.0092
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.3292 0.3348
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.024 0.3292 0.3368
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Echinococcus granulosus tm gpcr rhodopsin 0.0134 0.1779 0.1777
Onchocerca volvulus 0.0021 0.016 0.0259
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0031 0.0297 0.0303
Trichomonas vaginalis glutathione reductase, putative 0.024 0.3292 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0134 0.1779 0.1777
Schistosoma mansoni neuropeptide receptor 0.0134 0.1779 0.1777
Plasmodium falciparum glutathione reductase 0.024 0.3292 0.3368
Echinococcus multilocularis neuropeptide s receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0438 0.6132 0.6276
Schistosoma mansoni amine GPCR 0.0134 0.1779 0.1777
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0176 0.2375 0.7213
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0239 0.0243
Loa Loa (eye worm) runx1 0.0055 0.0644 0.0658
Trypanosoma cruzi trypanothione reductase, putative 0.024 0.3292 0.3368
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0041 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0493 0.0503
Schistosoma mansoni disulfide oxidoreductase 0.0064 0.0769 0.0767
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni hypothetical protein 0.0041 0.0439 0.0437
Echinococcus multilocularis high voltage activated calcium channel beta 0.0013 0.0049 0.0047
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.0769 0.0787
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.2208
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0123 0.0519
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0044 0.0493 0.0491
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0176 0.2375 0.7213
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0064 0.0769 0.2331
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0439 0.0437
Leishmania major dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3336
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0792 0.0809
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Plasmodium vivax ferrodoxin reductase, putative 0.0064 0.0769 0.0787
Echinococcus granulosus neuropeptides capa receptor 0.0134 0.1779 0.1777
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0064 0.0769 0.3236
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0493 0.0504
Schistosoma mansoni adenoreceptor 0.0134 0.1779 0.1777
Giardia lamblia Guanylate kinase 0.0013 0.0049 0.0144
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0064 0.0769 0.3236
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Chlamydia trachomatis thioredoxin reductase 0.0064 0.0769 0.2331
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0117 0.0089
Schistosoma mansoni biogenic amine (5HT) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0728 0.0744
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0137 0.1816 0.1857
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0061 0.0728 0.0744
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0064 0.0769 0.0785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0529 0.054
Chlamydia trachomatis guanylate kinase 0.0013 0.0049 0.0144
Echinococcus granulosus neuropeptides capa receptor 0.0134 0.1779 0.1777
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.3292 0.3348
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0134 0.1779 0.1777
Brugia malayi abnormal cell lineage protein 2 0.0013 0.0049 0.0048
Onchocerca volvulus 0.0438 0.6132 1
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni hypothetical protein 0.0098 0.1263 0.1262
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0033
Echinococcus multilocularis guanylate kinase 0.0013 0.0049 0.0047
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus granulosus guanylate kinase 0.0013 0.0049 0.0047
Echinococcus granulosus neuropeptide receptor A26 0.0134 0.1779 0.1777
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0064 0.0769 0.0767
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0439 0.0437
Mycobacterium tuberculosis Probable dehydrogenase 0.0064 0.0769 0.0758
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0205 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0062 0.006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Brugia malayi G protein-coupled receptor 0.0134 0.1779 0.1819
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.024 0.3292 0.3368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.0074
Loa Loa (eye worm) hypothetical protein 0.0044 0.0493 0.0503
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0064 0.0769 0.0767
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0123 0.037
Echinococcus multilocularis g-protein coupled receptor 0.0134 0.1779 0.1777
Echinococcus granulosus kelch ECH associated protein 1 0.0098 0.1259 0.1258
Echinococcus multilocularis guanylate kinase 0.0013 0.0049 0.0047
Trypanosoma cruzi metacaspase 5, putative 0.0132 0.1751 0.1791
Brugia malayi guanylate kinase 0.0013 0.0049 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Trypanosoma brucei NADH dehydrogenase 0.0064 0.0769 0.0785
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0134 0.1779 0.1777
Trypanosoma brucei lanosterol synthase 0.018 0.2429 0.2485
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0064 0.0769 0.0758
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0061 0.0728 0.3066
Trypanosoma brucei unspecified product 0.0034 0.0345 0.0352
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0124 0.1635 0.1633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Plasmodium vivax hypothetical protein, conserved 0.0132 0.1751 0.1792
Brugia malayi putative neuropeptide receptor NPR1 0.0134 0.1779 0.1819
Schistosoma mansoni mannosidase endo-alpha 0.0013 0.0049 0.0047
Toxoplasma gondii selenide, water dikinase 0.0064 0.0769 0.0787
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0062 0.0062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.024 0.3292 0.3368
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0064 0.0769 0.2331
Schistosoma mansoni microtubule-associated protein tau 0.0708 1 1
Trypanosoma cruzi metacaspase, putative 0.0132 0.1751 0.1791
Plasmodium falciparum geranylgeranyltransferase, putative 0.0044 0.0493 0.0503
Brugia malayi hypothetical protein 0.0041 0.0439 0.0448
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0123 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0297 0.0303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0138 0.0139
Schistosoma mansoni ATP-dependent RNA Helicase 0.0016 0.0088 0.0087
Entamoeba histolytica disulphide oxidoreductase, putative 0.0064 0.0769 0.3236
Onchocerca volvulus 0.0134 0.1779 0.2899
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0134 0.1779 0.1777
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0124 0.1635 0.1672
Loa Loa (eye worm) G-protein coupled receptor 0.0134 0.1779 0.1819
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.024 0.3292 0.3368
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0127 0.167 0.7033
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.0013 0.0049 0.0047
Plasmodium vivax geranylgeranyltransferase, putative 0.0044 0.0493 0.0504
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0064 0.0769 0.0785
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0061 0.0728 0.0727
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0062 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0692 0.9769 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0062 0.0261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0205 0.0865
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.0769 0.0787
Schistosoma mansoni amine GPCR 0.0134 0.1779 0.1777
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0064 0.0769 0.0785
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Schistosoma mansoni hypothetical protein 0.0174 0.2348 0.2346
Echinococcus granulosus disks large 3 0.0049 0.056 0.0558
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0064 0.0769 0.0758
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0134 0.1779 0.1777
Echinococcus multilocularis bloom syndrome protein 0.002 0.0138 0.0136
Schistosoma mansoni neuropeptide f receptor 76f 0.0134 0.1779 0.1777
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0439 0.0447
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.0744
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0728 0.0744
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) RecQ helicase 0.002 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Onchocerca volvulus Neuropeptide F receptor homolog 0.0134 0.1779 0.2899
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0933 0.0932
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0132 0.1751 0.1791
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0064 0.0769 0.0758
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Loa Loa (eye worm) melatonin receptor type 1A 0.0134 0.1779 0.1819
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0205 0.0619
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi AKH receptor 0.0134 0.1779 0.1819
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0138 0.0139
Echinococcus multilocularis orexin receptor type 2 0.0134 0.1779 0.1777
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0044 0.0493 0.0491
Brugia malayi Thioredoxin reductase 0.0692 0.9769 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.024 0.3292 0.3368
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0064 0.0769 0.0758
Onchocerca volvulus 0.0134 0.1779 0.2899
Onchocerca volvulus 0.0061 0.0728 0.1185
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0276 0.3806 0.3805
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0134 0.1769 0.1768
Echinococcus granulosus intermediate filament protein 0.0027 0.0239 0.0237
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0769 0.0785
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Brugia malayi Dopamine receptor protein 2 0.0134 0.1779 0.1819
Plasmodium falciparum guanylate kinase 0.0013 0.0049 0.0048
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0064 0.0769 0.3236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0117 0.0352
Toxoplasma gondii hypothetical protein 0.0061 0.0728 0.0745
Schistosoma mansoni caspase-7 (C14 family) 0.0173 0.2333 0.2332
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0138 0.0414
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0041
Loa Loa (eye worm) G-protein coupled receptor 0.0134 0.1779 0.1819
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0064 0.0769 0.2331
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0124 0.1635 0.4963
Giardia lamblia Prenyltransferase 0.0124 0.1635 0.4963
Loa Loa (eye worm) guanylate kinase 0.0016 0.0088 0.0089
Schistosoma mansoni opsin-like receptor 0.0134 0.1779 0.1777
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0138 0.0136
Echinococcus granulosus caspase 0.0276 0.3806 0.3805
Schistosoma mansoni biogenic amine receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0027 0.0239 0.0243
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0123 0.0095
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0124 0.1635 0.1673
Loa Loa (eye worm) hypothetical protein 0.0091 0.1157 0.1183
Schistosoma mansoni neuropeptide F-like receptor 0.0134 0.1779 0.1777
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0134 0.1779 0.2899
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0176 0.2375 0.243
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0064 0.0769 0.0758
Echinococcus granulosus hypothetical protein 0.0134 0.1779 0.1777
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0493 0.0503
Echinococcus granulosus biogenic amine 5HT receptor 0.0134 0.1779 0.1777
Trypanosoma brucei metacaspase MCA3 0.0132 0.1751 0.1791
Echinococcus multilocularis MAGUK p55 subfamily 0.0016 0.0088 0.0087
Schistosoma mansoni myosin xvIII 0.0134 0.1779 0.1777
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0134 0.1779 0.1777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0529 0.0528
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0016 0.0088 0.0089
Onchocerca volvulus 0.0134 0.1779 0.2899
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0064 0.0769 0.0758
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0205 0.0619
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0134 0.1779 0.1819
Brugia malayi ZU5 domain containing protein 0.0013 0.0049 0.0048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0205 0.0619
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.0013 0.0049 0.0144
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0138 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0209
Echinococcus multilocularis neuropeptide FF receptor 2 0.0134 0.1779 0.1777
Brugia malayi Peripheral plasma membrane protein CASK 0.0021 0.016 0.0162
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.1751 0.1792
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.0013 0.0049 0.0144
Leishmania major DNA polymerase eta, putative 0.0014 0.0062 0.0013
Trypanosoma cruzi trypanothione reductase, putative 0.0692 0.9769 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Schistosoma mansoni opsin-like receptor 0.0134 0.1779 0.1777
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0122
Brugia malayi glutamate synthase 0.0064 0.0769 0.0785
Leishmania major acetoin dehydrogenase e3 component-like protein 0.024 0.3292 0.3336
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Schistosoma mansoni alpha-1 adrenergic receptor 0.0134 0.1779 0.1777
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0493 0.1493
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.024 0.3292 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0239 0.0243
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0064 0.0769 0.0758
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.0769 0.0767
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.0769 0.0785
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0064 0.0769 0.0787
Mycobacterium ulcerans ferredoxin reductase 0.0064 0.0769 0.2331
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.2208
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0124 0.1635 0.1633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.024 0.3292 0.3368
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0064 0.0769 0.2331
Mycobacterium ulcerans NADH dehydrogenase 0.0064 0.0769 0.2331
Brugia malayi follicle stimulating hormone receptor 0.0134 0.1779 0.1819
Echinococcus granulosus MAGUK p55 subfamily 0.0016 0.0088 0.0087
Trypanosoma cruzi metacaspase, putative 0.0132 0.1751 0.1791
Echinococcus multilocularis caspase 8 0.0132 0.1751 0.175
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus multilocularis neuropeptide receptor 0.0134 0.1779 0.1777
Trypanosoma brucei metacaspase 0.0132 0.1751 0.1791
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.0769 0.0785
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0161
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0792 0.0809
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0048
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0117 0.012
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0134 0.1779 0.1777
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0134 0.1779 0.1777
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0127 0.167 0.1669
Trichomonas vaginalis mercuric reductase, putative 0.024 0.3292 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0134 0.1779 0.1777
Echinococcus granulosus serotonin receptor 0.0134 0.1779 0.1777
Leishmania major farnesyltransferase beta subunit 0.0124 0.1635 0.1631
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.0074
Echinococcus multilocularis lamin dm0 0.0027 0.0239 0.0237
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0138 0.0136
Plasmodium vivax RNA helicase-1, putative 0.0176 0.2375 0.2431
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0123 0.0077
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0127 0.167 0.1708
Echinococcus multilocularis g protein coupled receptor 0.0134 0.1779 0.1777
Trypanosoma brucei trypanothione reductase 0.0692 0.9769 1
Mycobacterium ulcerans monoxygenase 0.0064 0.0769 0.2331
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0792 0.0809
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0134 0.1779 0.1777
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0792 0.0809
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1259 0.1258
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Onchocerca volvulus 0.0027 0.0239 0.0387
Trypanosoma brucei Metacaspase-4 0.0132 0.1751 0.1791
Echinococcus multilocularis neuropeptide Y receptor 0.0134 0.1779 0.1777
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.0769 0.0785
Brugia malayi Melatonin receptor type 1A 0.0134 0.1779 0.1819
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0062 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0529 0.0528
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus g protein coupled receptor 0.0134 0.1779 0.1777
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0792 0.0791
Loa Loa (eye worm) TYRA-2 protein 0.0134 0.1779 0.1819
Echinococcus multilocularis 0.0016 0.0088 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0134 0.1779 0.1777
Echinococcus multilocularis allatostatin A receptor 0.0134 0.1779 0.1777
Onchocerca volvulus Cell death protein 3 homolog 0.0173 0.2333 0.3803
Echinococcus granulosus MAGUK p55 subfamily 0.0016 0.0088 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0708 1 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0064 0.0769 0.0785
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0016 0.0088 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0529 0.0528
Onchocerca volvulus 0.0134 0.1779 0.2899
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0061 0.0728 0.0744
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0205 0.0865
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0064 0.0769 0.074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.024 0.3292 0.3368
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0138 0.0141
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus sex peptide receptor 0.0134 0.1779 0.1777
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0176 0.2375 0.2431
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0123 0.037
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0064 0.0769 0.0758
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0134 0.1779 0.1777
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0124 0.1635 0.4963
Leishmania major eukaryotic initiation factor 4a, putative 0.0176 0.2375 0.2393
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0439 0.1328
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0439 0.1328
Mycobacterium ulcerans hypothetical protein 0.0024 0.0205 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0014 0.0014
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0728 0.0744
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0138 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0134 0.1779 0.1777
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0016 0.0088 0.0087
Schistosoma mansoni maguk P55 subfamily member 26 0.0016 0.0088 0.0087
Schistosoma mansoni hypothetical protein 0.0134 0.1779 0.1777
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0064 0.0769 0.2331
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Leishmania major trypanothione reductase 0.0692 0.9769 1
Brugia malayi hypothetical protein 0.0013 0.0049 0.0048
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0792 0.0791
Trypanosoma cruzi metacaspase, putative 0.0132 0.1751 0.1791
Echinococcus granulosus G protein coupled receptor 139 0.0134 0.1779 0.1777
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0061 0.0728 0.0745
Toxoplasma gondii guanylate kinase family protein 0.0013 0.0049 0.005
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0064 0.0769 0.0767
Loa Loa (eye worm) guanylate kinase 0.0013 0.0049 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Echinococcus granulosus 7TM GPCR rhodopsin 0.0134 0.1779 0.1777
Echinococcus multilocularis G-protein coupled receptor, putative 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0033
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0176 0.2375 0.2374
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0792 0.0791
Echinococcus granulosus allatostatin A receptor 0.0134 0.1779 0.1777
Trichomonas vaginalis guanylate kinase, putative 0.0013 0.0049 0.0144
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0013 0.0049 0.0047
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Mycobacterium ulcerans hypothetical protein 0.0064 0.0769 0.2331
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1751 0.5317
Schistosoma mansoni biogenic amine receptor 0.0134 0.1779 0.1777
Echinococcus granulosus g-protein coupled receptor 0.0134 0.1779 0.1777
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.0769 0.0767
Plasmodium vivax glutathione reductase, putative 0.0692 0.9769 1
Brugia malayi neuropeptide F receptor 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0061 0.0728 0.0744
Echinococcus granulosus MAGUK p55 subfamily 0.0016 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0026 0.0232 0.0236
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0134 0.1779 0.1819
Echinococcus granulosus fmrfamide receptor 0.0134 0.1779 0.1777
Schistosoma mansoni cell polarity protein 0.0049 0.056 0.0558
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0134 0.1779 0.1777
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Treponema pallidum oxidoreductase 0.0064 0.0769 0.2331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0529 0.0528
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0061 0.0728 0.0727
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0061 0.0728 0.0744
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Echinococcus multilocularis g protein coupled receptor 0.0134 0.1779 0.1777
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0209
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0138 0.0139
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.1751 0.1792
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0134 0.1779 0.1819
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0064 0.0769 0.0785
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0041 0.004
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0792 0.3335
Brugia malayi hypothetical protein 0.0134 0.1779 0.1819
Giardia lamblia Glutamate synthase 0.0064 0.0769 0.2331
Plasmodium falciparum eukaryotic initiation factor 4A 0.0176 0.2375 0.243
Brugia malayi Guanylate kinase family protein 0.0016 0.0088 0.0089
Giardia lamblia Rab geranylgeranyltransferase 0.0061 0.0728 0.2208
Loa Loa (eye worm) neuropeptide F receptor 0.0134 0.1779 0.1819
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0064 0.0769 0.2331
Loa Loa (eye worm) programmed cell death 8 0.0064 0.0769 0.0785
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0138 0.0139
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0064 0.0769 0.2331
Giardia lamblia NADH oxidase lateral transfer candidate 0.024 0.3292 1
Plasmodium falciparum glutathione reductase 0.0692 0.9769 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.024 0.3292 0.3368
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0439 0.0447
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0529 0.054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0205 0.0619
Echinococcus granulosus g protein coupled receptor 0.0134 0.1779 0.1777
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0138 0.0091
Schistosoma mansoni histamine h1 receptor 0.0134 0.1779 0.1777
Trypanosoma cruzi NADH dehydrogenase, putative 0.0064 0.0769 0.0785
Entamoeba histolytica guanylate kinase, putative 0.0013 0.0049 0.0206
Brugia malayi Guanylate kinase family protein 0.0013 0.0049 0.0048
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0124 0.1635 0.1672
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0161
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0064 0.0769 0.0758
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.3292 0.3348
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0016 0.0088 0.0087
Toxoplasma gondii exonuclease III APE 0.0019 0.0123 0.0126
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0118
Schistosoma mansoni neuropeptide receptor 0.0134 0.1779 0.1777
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0176 0.2375 0.2407
Echinococcus multilocularis lamin 0.0027 0.0239 0.0237
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0064 0.0769 0.2331
Brugia malayi larval opioid receptor 0.0134 0.1779 0.1819
Toxoplasma gondii thioredoxin reductase 0.0692 0.9769 1
Echinococcus granulosus neuropeptide s receptor 0.0134 0.1779 0.1777
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0134 0.1779 0.1777
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0064 0.0769 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0769 0.0785
Echinococcus multilocularis serotonin receptor 0.0134 0.1779 0.1777
Brugia malayi hypothetical protein 0.0438 0.6132 0.6276
Echinococcus multilocularis serotonin receptor 0.0134 0.1779 0.1777
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0728 0.0744
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0061 0.0728 0.0744
Giardia lamblia DINP protein human, muc B family 0.0021 0.0155 0.0467
Loa Loa (eye worm) guanylate kinase 0.0041 0.0439 0.0448
Echinococcus granulosus peptide allatostatin:somatostatin 0.0134 0.1779 0.1777
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.1635 0.1672
Echinococcus granulosus dna polymerase eta 0.0014 0.0062 0.006
Schistosoma mansoni neuropeptide receptor 0.0134 0.1779 0.1777
Onchocerca volvulus 0.0134 0.1779 0.2899
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0064 0.0769 0.2331
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1635 0.4963
Onchocerca volvulus 0.0041 0.0439 0.0713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Plasmodium vivax guanylate kinase, putative 0.0013 0.0049 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Schistosoma mansoni biogenic amine receptor 0.0134 0.1779 0.1777
Echinococcus granulosus tm gpcr rhodopsin 0.0134 0.1779 0.1777
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1259 0.1258
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0061 0.0728 0.0727
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Onchocerca volvulus 0.0134 0.1779 0.2899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0089
Brugia malayi polk-prov protein 0.0031 0.0297 0.0303
Brugia malayi ORL1-like opioid receptor 0.0134 0.1779 0.1819
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0092 0.0092
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0138 0.0414
Brugia malayi Guanylate kinase family protein 0.0054 0.0631 0.0645
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0064 0.0769 0.0787
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0127 0.167 0.1669
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0176 0.2375 0.2374
Leishmania major metacaspase, putative 0.0132 0.1751 0.1751
Mycobacterium tuberculosis Probable reductase 0.0064 0.0769 0.0758
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0123 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0134 0.1779 0.1777
Mycobacterium ulcerans glutamate synthase subunit beta 0.0064 0.0769 0.2331
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.3066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.1751 0.5317
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0134 0.1779 0.1777
Echinococcus multilocularis sex peptide receptor 0.0134 0.1779 0.1777
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0064 0.0769 0.2331
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0138 0.0139
Brugia malayi neuropeptide F receptor 0.0134 0.1779 0.1819
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0064 0.0769 0.3236
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1259 0.1258
Echinococcus multilocularis glutamate synthase 0.0064 0.0769 0.0767
Schistosoma mansoni caspase-7 (C14 family) 0.0276 0.3806 0.3805
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0345 0.0352
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0134 0.1779 0.1777
Schistosoma mansoni amine GPCR 0.0134 0.1779 0.1777
Schistosoma mansoni lamin 0.0027 0.0239 0.0237
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0064 0.0769 0.0785
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0062
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0062 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0134 0.1779 0.1777
Echinococcus granulosus tachykinin peptides receptor 99D 0.0134 0.1779 0.1777
Loa Loa (eye worm) glutathione reductase 0.0692 0.9769 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0123 0.0125
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0117 0.0352
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.024 0.3292 0.3291
Echinococcus multilocularis musashi 0.0027 0.0239 0.0237
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0155 0.011
Echinococcus multilocularis disks large 1 0.0013 0.0049 0.0047
Trypanosoma brucei guanylate kinase, putative 0.0013 0.0049 0.0048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0123 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Trypanosoma brucei metacaspase 5, putative 0.0132 0.1751 0.1791
Schistosoma mansoni neuropeptide receptor 0.0134 0.1779 0.1777
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0439 0.1328
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0064 0.0769 0.0785
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0118
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.0769 0.0787
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0064 0.0769 0.0767
Echinococcus granulosus geminin 0.0174 0.2348 0.2346
Schistosoma mansoni lamin 0.0027 0.0239 0.0237
Schistosoma mansoni sulfide quinone reductase 0.0064 0.0769 0.0767
Echinococcus multilocularis caspase 0.0276 0.3806 0.3805
Leishmania major hypothetical protein, conserved 0.0064 0.0769 0.074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0439 0.0447
Echinococcus granulosus eukaryotic initiation factor 4A 0.0176 0.2375 0.2374
Brugia malayi G-protein coupled receptor 0.0134 0.1779 0.1819
Schistosoma mansoni hypothetical protein 0.0134 0.1779 0.1777
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0064 0.0769 0.0767
Echinococcus multilocularis thioredoxin glutathione reductase 0.0692 0.9769 0.9769
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0124 0.1635 0.1673
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0728 0.2208
Onchocerca volvulus 0.0134 0.1779 0.2899
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0016 0.0088 0.0087
Plasmodium falciparum thioredoxin reductase 0.0692 0.9769 1
Brugia malayi Serotonin receptor 0.0134 0.1779 0.1819
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0134 0.1779 0.1819
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Echinococcus granulosus neuropeptide FF receptor 2 0.0134 0.1779 0.1777
Loa Loa (eye worm) hypothetical protein 0.0044 0.0493 0.0503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.024 0.3292 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0134 0.1779 0.1777
Echinococcus multilocularis MAGUK p55 subfamily 0.0016 0.0088 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0134 0.1779 0.1777
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0127 0.167 0.1669
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0012 0.0031 0.0089
Loa Loa (eye worm) thioredoxin reductase 0.0692 0.9769 1
Giardia lamblia Rab geranylgeranyltransferase 0.0061 0.0728 0.2208
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0123 0.0125
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.0769 0.2331
Leishmania major DNA polymerase kappa, putative 0.0021 0.0155 0.011
Loa Loa (eye worm) hypothetical protein 0.0134 0.1779 0.1819
Onchocerca volvulus 0.0134 0.1779 0.2899
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0398 0.0397
Echinococcus granulosus g protein coupled receptor 0.0134 0.1779 0.1777
Echinococcus granulosus rhodopsin orphan GPCR 0.0134 0.1779 0.1777
Echinococcus granulosus neuropeptide receptor 0.0134 0.1779 0.1777
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0728 0.0744
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0692 0.9769 1
Mycobacterium leprae Probable guanylate kinase Gmk (GMP kinase). 0.0013 0.0049 0.0144
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0493 0.0503
Schistosoma mansoni hypothetical protein 0.0174 0.2348 0.2346
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0062 0.006

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3 nM Anti tumor activity of the compound on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment ChEMBL. 10602712
IC50 (functional) = 1700 nM Anti tumor activity of the compound on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment ChEMBL. 10602712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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