Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3318 | 0.5995 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0644 | 1 | 0.5 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0068 | 0.000000045149 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0068 | 0.000000064246 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.032 | 0.0654 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1875 | 0.7661 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.032 | 0.0546 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.5612 |
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.3928 | 0.8345 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0068 | 0.036 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.1487 | 1 |
Echinococcus multilocularis | laminin | 0.0112 | 0.1211 | 0.4951 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0048 | 0.0254 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0248 | 0.3469 | 0.3451 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0255 | 0.0431 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1898 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus granulosus | Tolloid protein 1 | 0.0112 | 0.1211 | 0.6463 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1211 | 0.3519 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.7104 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0641 | 0.9962 | 0.9933 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.1332 | 0.3275 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.1487 | 0.3258 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1237 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.075 | 0.1769 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4391 | 0.9926 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2838 | 0.636 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.3928 | 1 |
Echinococcus granulosus | notch | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.000000047947 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.6077 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.7932 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0323 | 0.4693 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2838 | 0.5989 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.3928 | 0.7113 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0248 | 0.3469 | 0.4857 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0372 | 0.5503 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4243 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1308 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.3928 | 0.8862 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.3067 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1707 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.075 | 0.1568 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | Fibulin-1 precursor | 0.0112 | 0.1211 | 0.2473 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.5503 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.1487 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.2814 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0112 | 0.1211 | 0.2626 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.3928 | 0.8862 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.2422 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1487 | 0.3677 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0112 | 0.1211 | 0.2964 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.4003 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0248 | 0.3469 | 0.6211 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.409 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | fibrillin 1 | 0.0112 | 0.1211 | 0.4951 |
Onchocerca volvulus | 0.0129 | 0.1487 | 0.4366 | |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2473 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.0464 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.1028 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1746 | 0.1714 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0372 | 0.5503 | 0.5502 |
Onchocerca volvulus | 0.0084 | 0.075 | 0.2101 | |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.3928 | 0.3914 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0068 | 0.000000045149 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0641 | 0.9962 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.5388 |
Echinococcus granulosus | laminin | 0.0112 | 0.1211 | 0.6463 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.075 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1487 | 0.3258 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Schistosoma mansoni | egf-like domain protein | 0.0112 | 0.1211 | 0.2964 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0739 | 0.1739 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.2447 | 1 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0123 | 0.1396 | 0.2122 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.9714 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.1487 | 0.5 |
Onchocerca volvulus | 0.0239 | 0.3318 | 1 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.5443 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 1 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0068 | 0.0276 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.2477 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0068 | 0.000000064246 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1875 | 0.4681 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.1513 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0112 | 0.1211 | 0.2473 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0112 | 0.1211 | 0.4951 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.0911 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0068 | 0.036 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0048 | 0.0195 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1875 | 1 |
Echinococcus multilocularis | notch | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.0502 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2626 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0644 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0372 | 0.5503 | 0.2188 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKa | = 10.62 | pKa for compound was evaluated | ChEMBL. | 3336030 |
RBA (binding) | = 0.67 % | Binding affinity to thyroxine binding globulin (unknown origin) relative to T4 | ChEMBL. | 195056 |
Relative ED50 (functional) | = 18.1 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 25.6 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 18.1 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 25.6 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 25 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 30 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 25 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 30 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.