Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase | 0.0083 | 0.5292 | 0.5292 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0091 | 0.6068 | 0.6068 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0131 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0131 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0083 | 0.5292 | 0.5292 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0083 | 0.5292 | 0.4647 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.5114 | 0.5114 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0083 | 0.5292 | 0.4647 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0131 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5292 | 0.3595 |
Treponema pallidum | adenosine deaminase | 0.0083 | 0.5292 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0083 | 0.5292 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0131 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0131 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0083 | 0.5292 | 0.5292 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.5114 | 0.5114 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0091 | 0.6068 | 0.6068 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0131 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0131 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0131 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0131 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0131 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.5114 | 0.5114 |
Echinococcus multilocularis | adenosine deaminase | 0.0083 | 0.5292 | 0.5292 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0131 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0131 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0131 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.5114 | 0.5114 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0131 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0091 | 0.6068 | 0.6068 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0131 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0131 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 uM | Antagonistic activity against NR1A/2B receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 1 uM | Antagonistic activity against NR1A/2B receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 51 uM | Antagonistic activity against NR1A/2C receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 51 uM | Antagonistic activity against NR1A/2C receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 64 uM | Antagonistic activity against NR1A/2A receptors in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 64 uM | Antagonistic activity against NR1A/2A receptors in frog oocytes | ChEMBL. | 10741546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.