Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0246 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0246 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0246 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0246 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0246 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0246 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0246 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0246 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0246 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0042 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0246 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2 uM | In vitro activity expressed as EC50 for inhibition of collagen induced platelet aggregation. | ChEMBL. | 10197967 |
EC50 (functional) | = 2 uM | In vitro activity expressed as EC50 for inhibition of collagen induced platelet aggregation. | ChEMBL. | 10197967 |
IC50 (binding) | = 0.022 uM | In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (binding) | = 0.022 uM | In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (functional) | = 0.038 uM | In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (functional) | = 0.038 uM | In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets. | ChEMBL. | 10197967 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10197967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.