Detailed information for compound 257895

Basic information

Technical information
  • TDR Targets ID: 257895
  • Name: 2-[4-[(2S)-2-(benzenesulfonamido)-3-(4-hydrox yphenyl)propoxy]carbonyl-2,6-dihydroxybenzoyl ]-3-hydroxybenzoic acid
  • MW: 607.585 | Formula: C30H25NO11S
  • H donors: 6 H acceptors: 10 LogP: 4.46 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1ccc(cc1)C[C@H](NS(=O)(=O)c1ccccc1)COC(=O)c1cc(O)c(c(c1)O)C(=O)c1c(O)cccc1C(=O)O
  • InChi: 1S/C30H25NO11S/c32-20-11-9-17(10-12-20)13-19(31-43(40,41)21-5-2-1-3-6-21)16-42-30(39)18-14-24(34)27(25(35)15-18)28(36)26-22(29(37)38)7-4-8-23(26)33/h1-12,14-15,19,31-35H,13,16H2,(H,37,38)/t19-/m0/s1
  • InChiKey: PQWWKDOKHDWZBH-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(2S)-2-(benzenesulfonamido)-3-(4-hydroxyphenyl)propoxy]carbonyl-2,6-dihydroxy-benzoyl]-3-hydroxy-benzoic acid
  • 2-[[4-[[(2S)-2-(benzenesulfonamido)-3-(4-hydroxyphenyl)propoxy]-oxomethyl]-2,6-dihydroxyphenyl]-oxomethyl]-3-hydroxybenzoic acid
  • 2-[2,6-dihydroxy-4-[(2S)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonyl-phenyl]carbonyl-3-hydroxy-benzoic acid
  • 2-[2,6-dihydroxy-4-[(2S)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonylbenzoyl]-3-hydroxybenzoic acid
  • 2-[2,6-dihydroxy-4-[(2S)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonyl-benzoyl]-3-hydroxy-benzoic acid
  • 2-[[2,6-dihydroxy-4-[[(2S)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]-oxomethyl]phenyl]-oxomethyl]-3-hydroxybenzoic acid
  • Acyclic Balanol Analog 12b(S)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, delta Starlite/ChEMBL References
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References
Homo sapiens protein kinase C, epsilon Starlite/ChEMBL References
Homo sapiens protein kinase C, gamma Starlite/ChEMBL References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens protein kinase C, eta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K06068 novel protein kinase C, putative Get druggable targets OG5_129314 All targets in OG5_129314
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine:threonine protein kinase N2 Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ETA protein kinase Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase c epsilon type Get druggable targets OG5_129314 All targets in OG5_129314
Echinococcus multilocularis protein kinase c epsilon type Get druggable targets OG5_129314 All targets in OG5_129314
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus serine:threonine protein kinase N2 Get druggable targets OG5_129314 All targets in OG5_129314
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C epsilon type, putative Get druggable targets OG5_129314 All targets in OG5_129314
Brugia malayi protein kinase C II. Get druggable targets OG5_129314 All targets in OG5_129314
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0136 0.0232
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0031 0.0052
Brugia malayi Protein kinase domain containing protein 0.0049 0.0213 0.0183
Brugia malayi RhoGAP domain containing protein 0.0046 0.014 0.011
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0147 0.2571 0.5
Loa Loa (eye worm) hypothetical protein 0.0167 0.3034 0.3012
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0153 0.2719 0.2697
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0049 0.0213 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.2571 0.4232
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.014 0.0006
Loa Loa (eye worm) SRC-1 0.0045 0.0136 0.0106
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0066 0.0632 0.1073
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.5319 0.901
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0049 0.0213 0.0183
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Loa Loa (eye worm) hypothetical protein 0.0188 0.3555 0.3535
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0147 0.2571 0.5
Loa Loa (eye worm) integrin beta-2 0.0331 0.6955 0.6945
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0066 0.0632 0.1073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Schistosoma mansoni serine/threonine kinase 0.0066 0.0632 0.0862
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Echinococcus granulosus protein kinase c eta type 0.0046 0.014 0.0238
Brugia malayi Kelch motif family protein 0.005 0.0251 0.0221
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0031 0.0052
Schistosoma mansoni integrin beta subunit 0.0195 0.3704 0.6204
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0049 0.0213 0.0183
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0066 0.0632 0.1073
Echinococcus granulosus tyrosine kinase 0.0041 0.0031 0.0052
Loa Loa (eye worm) hypothetical protein 0.0458 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.014 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0632 0.0862
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0632 0.0603
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0053 0.0321 0.0546
Brugia malayi Integrin beta pat-3 precursor 0.0331 0.6955 0.6945
Toxoplasma gondii AGC kinase 0.0147 0.2571 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0136 0.0232
Onchocerca volvulus 0.0053 0.0321 0.0626
Echinococcus granulosus N chimaerin 0.005 0.0249 0.0423
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Loa Loa (eye worm) kelch domain-containing protein family protein 0.005 0.0251 0.0221
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0147 0.2571 0.2548
Echinococcus multilocularis Rac GTPase activating protein 1 0.0046 0.014 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Leishmania major protein kinase A catalytic subunit isoform 1 0.0147 0.2571 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0632 0.0862
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0262 0.5319 0.9033
Echinococcus multilocularis serine:threonine protein kinase N2 0.0233 0.4616 0.784
Echinococcus multilocularis serine:threonine protein kinase 38 0.0066 0.0632 0.1073
Brugia malayi Protein kinase c protein 2 0.0199 0.3809 0.3791
Brugia malayi hypothetical protein 0.005 0.0251 0.0221
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0136 0.0232
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0136 0.0232
Loa Loa (eye worm) hypothetical protein 0.0147 0.2571 0.2548
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0049 0.0213 0.0362
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0136 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0632 0.0862
Echinococcus multilocularis myotubularin protein 13 0.0046 0.014 0.0238
Echinococcus multilocularis protein kinase c epsilon type 0.0286 0.5888 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0321 0.0292
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0147 0.2571 0.5
Brugia malayi p70 ribosomal S6 kinase beta 0.0066 0.0632 0.0603
Echinococcus granulosus integrin beta 2 0.0245 0.4906 0.8332
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0066 0.0632 0.0603
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0249 0.0195
Brugia malayi Ras association domain family 1 isoform A 0.0046 0.014 0.011
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Leishmania major protein kinase A catalytic subunit isoform 2 0.0147 0.2571 0.5
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147 0.2571 0.5
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0046 0.014 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0171 0.0059
Brugia malayi SRC-1 0.0045 0.0136 0.0106
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147 0.2571 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0047 0.0171 0.029
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0213 0.0134
Loa Loa (eye worm) hypothetical protein 0.005 0.0251 0.0221
Entamoeba histolytica protein kinase, putative 0.0066 0.0632 0.1658
Trichomonas vaginalis AGC family protein kinase 0.0147 0.2571 1
Echinococcus multilocularis protein kinase c eta type 0.0046 0.014 0.0238
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Echinococcus granulosus protein kinase C gamma type 0.0217 0.4228 0.7181
Entamoeba histolytica protein kinase, putative 0.0066 0.0632 0.1658
Brugia malayi Protein kinase domain containing protein 0.0066 0.0632 0.0603
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0066 0.0632 0.1073
Entamoeba histolytica protein kinase, putative 0.0066 0.0632 0.1658
Echinococcus granulosus unc 13 munc13 0.0053 0.0321 0.0546
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0136 0.0232
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Loa Loa (eye worm) hypothetical protein 0.0143 0.2465 0.2441
Entamoeba histolytica PH domain containing protein kinase, putative 0.0147 0.2571 0.8192
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0632 0.0862
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1809 0.3073
Leishmania major protein kinase A catalytic subunit 0.0147 0.2571 0.5
Echinococcus multilocularis serine threonine protein kinase 0.0217 0.4228 0.7181
Echinococcus granulosus Diacylglycerol kinase theta 0.0046 0.014 0.0238
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0031 0.0052
Schistosoma mansoni lipoxygenase 0.0115 0.1809 0.2909
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.5319 0.901
Toxoplasma gondii AGC kinase 0.0147 0.2571 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0046 0.014 0.011
Entamoeba histolytica protein kinase, putative 0.0066 0.0632 0.1658
Schistosoma mansoni hypothetical protein 0.0046 0.014 0.0006
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0066 0.0632 0.0603
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.005 0.0249 0.0423
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0066 0.0632 0.1073
Loa Loa (eye worm) hypothetical protein 0.0212 0.4124 0.4106
Brugia malayi diacylglycerol kinase 0.0046 0.014 0.011
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0049 0.0213 0.0362
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0066 0.0632 0.1073
Loa Loa (eye worm) hypothetical protein 0.0233 0.4616 0.46
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0147 0.2571 1
Toxoplasma gondii AGC kinase 0.0066 0.0632 0.2023
Brugia malayi Variant SH3 domain containing protein 0.005 0.0249 0.0219
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0286 0.5888 0.5875
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1809 0.3073
Echinococcus multilocularis Diacylglycerol kinase theta 0.0046 0.014 0.0238
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0031 0.0052
Echinococcus multilocularis unc 13 (munc13) 0.0053 0.0321 0.0546
Loa Loa (eye worm) hypothetical protein 0.0167 0.3034 0.3012
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147 0.2571 0.2548
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0144 0.2497 0.4242
Brugia malayi Protein kinase domain containing protein 0.0066 0.0632 0.0603
Loa Loa (eye worm) hypothetical protein 0.0167 0.3034 0.3012
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0031 0.0052
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0249 0.0195
Brugia malayi protein kinase C II. 0.0286 0.5888 0.5875
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Echinococcus granulosus Rac GTPase activating protein 1 0.0046 0.014 0.0238
Echinococcus multilocularis serine:threonine protein kinase N2 0.0066 0.0632 0.1073
Echinococcus multilocularis N chimaerin 0.005 0.0249 0.0423
Brugia malayi Protein kinase domain containing protein 0.0066 0.0632 0.0603
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0147 0.2571 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.005 0.0249 0.0219
Loa Loa (eye worm) AGC/NDR protein kinase 0.0066 0.0632 0.0603
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0136 0.0232
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0321 0.0322
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0147 0.2571 0.5
Echinococcus granulosus myotubularin protein 13 0.0046 0.014 0.0238
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Brugia malayi diacylglycerol kinase 0.0046 0.014 0.011
Onchocerca volvulus 0.0167 0.3034 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0053 0.0321 0.0546
Brugia malayi Hr1 repeat family protein 0.0066 0.0632 0.0603
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0143 0.2465 0.4186
Echinococcus granulosus NDR protein kinase 0.0066 0.0632 0.1073
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0213 0.0134
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0066 0.0632 0.0603
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.005 0.0249 0.0423
Giardia lamblia Kinase, AGC PKA 0.0147 0.2571 0.5
Schistosoma mansoni protein kinase C 0.0053 0.0321 0.0322
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.2571 0.4232
Loa Loa (eye worm) AGC/PKN protein kinase 0.0066 0.0632 0.0603
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0144 0.2497 0.4242
Brugia malayi Pleckstrin Homology Domain 0.0046 0.014 0.011
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0147 0.2571 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Echinococcus granulosus serine:threonine protein kinase N2 0.017 0.3107 0.5277
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.014 0.0006
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0066 0.0632 0.0603
Schistosoma mansoni vav2 0.005 0.0249 0.0195
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0136 0.0232
Brugia malayi C1-like domain containing protein 0.0049 0.0213 0.0183
Echinococcus granulosus serine:threonine protein kinase N2 0.0066 0.0632 0.1073
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Echinococcus multilocularis integrin beta 2 0.0245 0.4906 0.8332
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.021 0.0356
Echinococcus granulosus raf serine:threonine protein kinase 0.0047 0.0171 0.029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0136 0.0232
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.5888 1
Schistosoma mansoni lipoxygenase 0.0081 0.0979 0.1465
Echinococcus multilocularis protein kinase c iota type 0.0112 0.1722 0.2926
Brugia malayi RhoGEF domain containing protein 0.0046 0.014 0.011
Echinococcus granulosus protein kinase c epsilon type 0.0286 0.5888 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.017 0.3107 1
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0321 0.0322
Echinococcus granulosus protein kinase c iota type 0.0112 0.1722 0.2926
Entamoeba histolytica PH domain containing protein kinase, putative 0.0147 0.2571 0.8192
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.011
Schistosoma mansoni atypical protein kinase C 0.0112 0.1722 0.2758
Schistosoma mansoni protein kinase C mu 0.0046 0.014 0.0006
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147 0.2571 0.2548
Echinococcus granulosus RNA directed DNA polymerase 0.0143 0.2465 0.4186
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Brugia malayi protein kinase C3,putative 0.0049 0.0213 0.0183
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.2571 0.4366
Schistosoma mansoni protein kinase C mu 0.0049 0.0213 0.0134
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0136 0.0232
Echinococcus granulosus Protein kinase C brain isozyme 0.0262 0.5319 0.9033
Brugia malayi RhoGAP domain containing protein 0.005 0.0249 0.0219
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0632 0.0364
Schistosoma mansoni rac gtpase activating protein 0.0046 0.014 0.0006
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0147 0.2571 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0136 0.0232
Echinococcus multilocularis RNA directed DNA polymerase 0.0143 0.2465 0.4186
Loa Loa (eye worm) raf kinase 0.0046 0.014 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.2571 0.4232

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Evaluated against recombinant human Protein kinase C beta 2 ChEMBL. 8978850
IC50 (binding) = 0.02 uM Evaluated against recombinant human Protein kinase C nu ChEMBL. 8978850
IC50 (binding) = 0.02 uM Evaluated against recombinant human Protein kinase C beta 2 ChEMBL. 8978850
IC50 (binding) = 0.02 uM Evaluated against recombinant human Protein kinase C nu ChEMBL. 8978850
IC50 (binding) = 0.03 uM Evaluated against recombinant human Protein kinase C delta ChEMBL. 8978850
IC50 (binding) = 0.03 uM Evaluated against recombinant human Protein kinase C delta ChEMBL. 8978850
IC50 (binding) = 0.23 uM Evaluated against recombinant human Protein kinase C beta 1 ChEMBL. 8978850
IC50 (binding) = 0.23 uM Evaluated against recombinant human Protein kinase C beta 1 ChEMBL. 8978850
IC50 (binding) = 1.9 uM Evaluated against recombinant human Protein kinase C alpha ChEMBL. 8978850
IC50 (binding) = 1.9 uM Evaluated against recombinant human Protein kinase C alpha ChEMBL. 8978850
IC50 (binding) = 2.3 uM Evaluated against recombinant human Protein kinase C epsilon ChEMBL. 8978850
IC50 (binding) = 2.3 uM Evaluated against recombinant human Protein kinase C epsilon ChEMBL. 8978850
IC50 (binding) = 2.6 uM Evaluated against recombinant human Protein kinase C gamma ChEMBL. 8978850
IC50 (binding) = 2.6 uM Evaluated against recombinant human Protein kinase C gamma ChEMBL. 8978850
IC50 (binding) > 50 uM Evaluated against recombinant human Protein Kinase A (PKA) ChEMBL. 8978850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.