Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0385 | 0.7105 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0079 | 0.1017 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0377 | 0.03 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0079 | 0.1017 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Loa Loa (eye worm) | TAR-binding protein | 0.0206 | 0.3538 | 0.4923 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0151 | 0.0073 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.03 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0377 | 0.03 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.03 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0206 | 0.3538 | 0.4923 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.3538 | 0.3486 |
Echinococcus multilocularis | heat shock protein | 0.0048 | 0.0398 | 0.0322 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0154 | 0.2501 | 0.2442 |
Schistosoma mansoni | hypothetical protein | 0.0531 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.3538 | 0.3486 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1017 | 0.1335 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.1317 |
Loa Loa (eye worm) | endoplasmin | 0.0048 | 0.0398 | 0.0454 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0067 | 0.0789 | 0.0715 |
Echinococcus multilocularis | tar DNA binding protein | 0.0206 | 0.3538 | 0.3486 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.2501 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0067 | 0.0789 | 0.7563 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.2501 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.1017 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0048 | 0.0398 | 0.1074 |
Brugia malayi | Isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.101 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0032 | 0.0079 | 0.5 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0045 | 0.034 | 0.5 |
Echinococcus multilocularis | heat shock protein 90 | 0.0048 | 0.0398 | 0.0322 |
Brugia malayi | TAR-binding protein | 0.0206 | 0.3538 | 0.4923 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0067 | 0.0789 | 0.7563 |
Echinococcus granulosus | heat shock protein | 0.0048 | 0.0398 | 0.0322 |
Schistosoma mansoni | heat shock protein | 0.0048 | 0.0398 | 0.0322 |
Plasmodium vivax | endoplasmin, putative | 0.0048 | 0.0398 | 0.1074 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0181 | 0.305 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Echinococcus multilocularis | endoplasmin | 0.0045 | 0.034 | 0.0263 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0045 | 0.034 | 0.2779 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.3538 | 0.3486 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0385 | 0.7105 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0206 | 0.3538 | 0.3486 |
Brugia malayi | MH2 domain containing protein | 0.0385 | 0.7105 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.0398 | 0.3401 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0461 | 0.0543 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.3538 | 0.3486 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0181 | 0.305 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Echinococcus granulosus | heat shock protein 90 | 0.0048 | 0.0398 | 0.0322 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0041 | 0.0261 | 0.0183 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0079 | 0.1017 | 0.3335 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0377 | 0.03 |
Plasmodium vivax | heat shock protein, putative | 0.0181 | 0.305 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0377 | 0.03 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Echinococcus granulosus | heat shock protein 90 | 0.0041 | 0.0261 | 0.0183 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0154 | 0.2501 | 0.2442 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.2501 | 0.2442 |
Trichomonas vaginalis | heat shock protein, putative | 0.0048 | 0.0398 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0045 | 0.034 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.2388 |
Brugia malayi | isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.101 |
Echinococcus multilocularis | geminin | 0.0531 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0048 | 0.0398 | 0.0454 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.034 | 0.8533 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.2501 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.0398 | 0.3401 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Brugia malayi | heat shock protein 90 | 0.0048 | 0.0398 | 0.0454 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0067 | 0.0789 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0079 | 0.1017 | 0.3335 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0067 | 0.0789 | 0.7563 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.03 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.2501 | 1 |
Brugia malayi | RNA binding protein | 0.0206 | 0.3538 | 0.4923 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0041 | 0.0261 | 0.1937 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.0715 |
Treponema pallidum | heat shock protein 90 | 0.0045 | 0.034 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0377 | 0.0424 |
Echinococcus granulosus | endoplasmin | 0.0045 | 0.034 | 0.0263 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0067 | 0.0789 | 0.7563 |
Plasmodium falciparum | endoplasmin, putative | 0.0035 | 0.0137 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1017 | 0.1335 |
Echinococcus multilocularis | heat shock protein 90 | 0.0041 | 0.0261 | 0.0183 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0154 | 0.2501 | 0.2442 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0377 | 0.0424 |
Brugia malayi | hypothetical protein | 0.0154 | 0.2501 | 0.3448 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0035 | 0.0151 | 0.0073 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0079 | 0.1017 | 0.3157 |
Schistosoma mansoni | heat shock protein | 0.0048 | 0.0398 | 0.0322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.3538 | 0.3486 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0045 | 0.034 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0067 | 0.0789 | 0.7563 |
Schistosoma mansoni | endoplasmin | 0.0048 | 0.0398 | 0.0322 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0048 | 0.0398 | 0.1074 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0041 | 0.0261 | 0.1937 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0079 | 0.1017 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Trichomonas vaginalis | heat shock protein, putative | 0.0041 | 0.0261 | 0.655 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.3401 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.3401 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0035 | 0.0151 | 0.0073 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0067 | 0.0789 | 0.2585 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0067 | 0.0789 | 0.2388 |
Loa Loa (eye worm) | RNA binding protein | 0.0206 | 0.3538 | 0.4923 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0206 | 0.3538 | 0.4923 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.0398 | 0.3401 |
Schistosoma mansoni | hypothetical protein | 0.0531 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.1317 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.034 | 0.8533 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0048 | 0.0398 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0035 | 0.0137 | 0.345 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0079 | 0.1017 | 0.3157 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0067 | 0.0789 | 0.2388 |
Giardia lamblia | Grp94/Hsp90 | 0.0045 | 0.034 | 0.5748 |
Trichomonas vaginalis | heat shock protein, putative | 0.0035 | 0.0137 | 0.345 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.0398 | 0.3401 |
Brugia malayi | Endoplasmin precursor | 0.0048 | 0.0398 | 0.0454 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0048 | 0.0398 | 0.3401 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Schistosoma mansoni | endoplasmin | 0.0048 | 0.0398 | 0.0322 |
Plasmodium falciparum | heat shock protein 90 | 0.0048 | 0.0398 | 0.1305 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0048 | 0.0398 | 0.1074 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.0398 | 0.3401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 50 ug ml-1 | In vitro inhibition of KB cell growth | ChEMBL. | 3599030 |
T/C (functional) | 0 % | In vivo antitumor activity against leukemia P388 in mice at 400 mg/kg dosage administered intraperitoneally once a day for 1 and 5 days; compound is inactive | ChEMBL. | 3599030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.