Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 90 nM | Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced increases in intracellular [Ca2+] levels | ChEMBL. | 14698197 |
IC50 (functional) | = 90 nM | Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced increases in intracellular [Ca2+] levels | ChEMBL. | 14698197 |
Ki (binding) | = 1 nM | Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligand | ChEMBL. | 14698197 |
Ki (binding) | = 1 nM | Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligand | ChEMBL. | 14698197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.