Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0165 | 0.0235 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0791 | 0.6321 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1169 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0791 | 0.6321 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0815 | 0.6556 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2 nM | Transcriptional activation of retinoic acid receptor RAR beta | ChEMBL. | No reference |
EC50 (binding) | = 2 nM | Transcriptional activation of retinoic acid receptor RAR beta | ChEMBL. | No reference |
EC50 (binding) | = 7 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor beta | ChEMBL. | 11277515 |
EC50 (binding) | = 7 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor beta | ChEMBL. | 11277515 |
EC50 (binding) | = 10 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor gamma | ChEMBL. | 11277515 |
EC50 (binding) | = 10 nM | Transcriptional activation of retinoic acid receptor RAR gamma | ChEMBL. | No reference |
EC50 (binding) | = 10 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor gamma | ChEMBL. | 11277515 |
EC50 (binding) | = 10 nM | Transcriptional activation of retinoic acid receptor RAR gamma | ChEMBL. | No reference |
EC50 (binding) | = 435 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor alpha | ChEMBL. | 11277515 |
EC50 (binding) | = 435 nM | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor alpha | ChEMBL. | 11277515 |
EC50 (binding) | = 598 nM | Transcriptional activation of retinoic acid receptor RAR alpha | ChEMBL. | No reference |
EC50 (binding) | = 598 nM | Transcriptional activation of retinoic acid receptor RAR alpha | ChEMBL. | No reference |
EC50 (binding) | = 10000 nM | Transcriptional activation of retinoid X receptor RXR alpha; not active | ChEMBL. | No reference |
EC50 (binding) | = 10000 nM | Transcriptional activation of retinoid X receptor RXR alpha; not active | ChEMBL. | No reference |
IC80 (functional) | = 0.46 nM | In vivo inhibition of TPA-induced ornithine decarboxylase (ODC) activity in hairless mouse skin | ChEMBL. | No reference |
IC80 (functional) | = 0.46 nM | In vivo inhibition of TPA-induced ornithine decarboxylase (ODC) activity in hairless mouse skin | ChEMBL. | No reference |
Kd (binding) | = 20 nM | Binding affinity towards retinoic acid receptor beta was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Kd (binding) | = 20 nM | Binding affinity towards retinoic acid receptor beta was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Kd (binding) | = 135 nM | Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Kd (binding) | = 135 nM | Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Kd (binding) | = 190 nM | Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Kd (binding) | = 190 nM | Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligand | ChEMBL. | 11277515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.