Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell adhesion molecule | 0.0037 | 0.1871 | 0.3114 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Brugia malayi | Blistered cuticle protein 3 | 0.0048 | 0.4095 | 0.4095 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.4095 | 0.4095 |
Onchocerca volvulus | 0.0048 | 0.4095 | 0.5062 | |
Schistosoma mansoni | peroxidasin | 0.0048 | 0.4095 | 0.6817 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0044 | 0.3291 | 0.3291 |
Onchocerca volvulus | Dual oxidase homolog | 0.0048 | 0.4095 | 0.5062 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.4095 | 0.5062 |
Onchocerca volvulus | 0.0048 | 0.4095 | 0.5062 | |
Brugia malayi | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0044 | 0.3291 | 0.3291 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0048 | 0.4095 | 0.5062 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Echinococcus granulosus | peroxidasin | 0.0076 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0047 | 0.3952 | 0.3952 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5864 | 0.5864 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.4095 | 0.5062 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Echinococcus granulosus | roundabout 2 | 0.0056 | 0.5864 | 0.5864 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0048 | 0.4095 | 0.4095 |
Echinococcus multilocularis | peroxidasin | 0.0076 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0047 | 0.3952 | 0.658 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Echinococcus multilocularis | roundabout 2 | 0.0056 | 0.5864 | 0.5864 |
Echinococcus multilocularis | neuroglian | 0.0047 | 0.3952 | 0.3952 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0067 | 0.8088 | 0.8088 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0037 | 0.1871 | 0.1871 |
Onchocerca volvulus | 0.0048 | 0.4095 | 0.5062 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.4095 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4095 | 0.4095 |
Onchocerca volvulus | Peroxidasin homolog | 0.0067 | 0.8088 | 1 |
Schistosoma mansoni | peroxidasin | 0.0057 | 0.6006 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0067 | 0.8088 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.4095 | 0.4095 |
Brugia malayi | Animal haem peroxidase family protein | 0.0067 | 0.8088 | 0.8088 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5864 | 0.5864 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0035 | 0.1421 | 0.2366 |
Echinococcus granulosus | neuroglian | 0.0047 | 0.3952 | 0.3952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 1 uM | Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 66 uM | Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 66 uM | Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
Ratio (binding) | = 66 | Selectivity as ratio of IC50 against COX-1 to IC50 against COX-2 | ChEMBL. | 11844663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.