Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.00000036 M | Inhibition of specific binding of [125I]-Angiotensin II (0.2 nM) to angiotensin II receptor in bovine adrenal cortex | ChEMBL. | 8978851 |
Inhibition (functional) | = 88 % | Percent inhibition of angiotensin II (0.1 microg/kg iv) -induced pressor response 3h after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats | ChEMBL. | 8978851 |
Inhibition (functional) | = 88 % | Percent inhibition of angiotensin II (0.1 microg/kg iv) -induced pressor response 3h after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats | ChEMBL. | 8978851 |
Inhibition (functional) | = 91 % | Percent inhibition of angiotensin II (0.1 microg/kg iv) -induced pressor response 7 hr after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats | ChEMBL. | 8978851 |
Inhibition (functional) | = 91 % | Percent inhibition of angiotensin II (0.1 microg/kg iv) -induced pressor response 7 hr after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats | ChEMBL. | 8978851 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.