Detailed information for compound 258556

Basic information

Technical information
  • TDR Targets ID: 258556
  • Name: N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[1,2-c] pyrazol-5-yl]-2-piperazin-1-ylacetamide
  • MW: 417.46 | Formula: C23H23N5O3
  • H donors: 3 H acceptors: 3 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1[nH]nc2c1C(=O)c1c2cccc1NC(=O)CN1CCNCC1
  • InChi: 1S/C23H23N5O3/c1-31-15-7-5-14(6-8-15)21-20-22(27-26-21)16-3-2-4-17(19(16)23(20)30)25-18(29)13-28-11-9-24-10-12-28/h2-8,24H,9-13H2,1H3,(H,25,29)(H,26,27)
  • InChiKey: PVXGUOAMKJRLQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-2-piperazin-1-yl-acetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-2-(1-piperazinyl)acetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-2-piperazin-1-yl-ethanamide
  • N-[4-keto-3-(4-methoxyphenyl)-1H-indeno[1,2-c]pyrazol-5-yl]-2-piperazino-acetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[2,1-d]pyrazol-5-yl]-2-piperazin-1-ylacetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[2,1-d]pyrazol-5-yl]-2-piperazin-1-yl-acetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[2,1-d]pyrazol-5-yl]-2-(1-piperazinyl)acetamide
  • N-[4-keto-3-(4-methoxyphenyl)-1H-indeno[2,1-d]pyrazol-5-yl]-2-piperazin-1-yl-acetamide
  • N-[3-(4-methoxyphenyl)-4-oxo-1H-indeno[2,1-d]pyrazol-5-yl]-2-piperazin-1-yl-ethanamide
  • Indenopyrazole 6d

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens cyclin E2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide receptor A26 0.0073 0.2187 0.2187
Echinococcus multilocularis g protein coupled receptor 0.0073 0.2187 0.2187
Brugia malayi Dopamine receptor protein 1 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.2187 0.2187
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.2187 0.2187
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.2187 0.2187
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Giardia lamblia G2/mitotic-specific cyclin B 0.0043 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.2187 0.2187
Echinococcus granulosus orexin receptor type 2 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine receptor 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi neuropeptide F receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni opsin-like receptor 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.2187 0.2187
Schistosoma mansoni histamine h1 receptor 0.0073 0.2187 0.2187
Schistosoma mansoni opsin-like receptor 0.0073 0.2187 0.2187
Schistosoma mansoni amine GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide receptor A26 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi larval opioid receptor 0.0073 0.2187 0.2187
Brugia malayi G-protein coupled receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0104 0.4424 0.4424
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus granulosus somatostatin receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.2187 0.2187
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.2187 0.2187
Echinococcus granulosus g-protein coupled receptor 0.0073 0.2187 0.2187
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.2187 0.2187
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.7485 1
Schistosoma mansoni hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi ORL1-like opioid receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.7485 1
Echinococcus multilocularis serotonin transporter 0.0182 1 1
Brugia malayi Melatonin receptor type 1A 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni myosin xvIII 0.0073 0.2187 0.2187
Giardia lamblia Cyclin A 0.0043 0 0.5
Brugia malayi putative neuropeptide receptor 0.0073 0.2187 0.2187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus serotonin transporter 0.0182 1 1
Echinococcus multilocularis sex peptide receptor 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.2187 0.2187
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.2187 0.2187
Schistosoma mansoni hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni sodium/chloride dependent transporter 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Entamoeba histolytica cyclin, putative 0.0043 0 0.5
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide receptor 0.0073 0.2187 0.2187
Echinococcus granulosus g protein coupled receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.2187 0.2187
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.2187 0.2187
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.7485 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis G protein coupled receptor 139 0.0073 0.2187 0.2187
Brugia malayi follicle stimulating hormone receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) serotonin transporter b 0.0182 1 1
Echinococcus multilocularis orexin receptor type 2 0.0073 0.2187 0.2187
Brugia malayi AKH receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.2187 0.2187
Giardia lamblia Hypothetical protein 0.0043 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.2187 0.2187
Brugia malayi thymidylate synthase 0.0104 0.4424 0.4424
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.2187 0.2187
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.7485 1
Brugia malayi G-protein coupled receptor 0.0073 0.2187 0.2187
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.2187 0.2187
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.2187 0.2187
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.2187 0.2187
Echinococcus granulosus serotonin receptor 0.0073 0.2187 0.2187
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.4424 1
Echinococcus multilocularis serotonin receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.2187 0.2187
Schistosoma mansoni amine GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.2187 0.2187
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.2187 0.2187
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.2187 0.2187
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.2187 0.2187
Loa Loa (eye worm) thymidylate synthase 0.0104 0.4424 0.4424
Schistosoma mansoni adenoreceptor 0.0073 0.2187 0.2187
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0182 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Brugia malayi sulfakinin receptor protein 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.2187 0.2187
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.4424 0.4424
Echinococcus granulosus hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Entamoeba histolytica cyclin, putative 0.0043 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.2187 0.2187
Echinococcus granulosus g protein coupled receptor 0.0073 0.2187 0.2187
Entamoeba histolytica cyclin family protein 0.0043 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0073 0.2187 0.2187
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus multilocularis somatostatin receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide receptor 0.0073 0.2187 0.2187
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.2187 0.2187
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.4424 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.005 0.0488 0.0488
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.7485 0.5
Brugia malayi RE15519p 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide s receptor 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) norepinephrine transporter 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis thymidylate synthase 0.0104 0.4424 0.4424
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni opsin-like receptor 0.0073 0.2187 0.2187
Treponema pallidum sodium- and chloride- dependent transporter 0.0182 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Echinococcus multilocularis fmrfamide receptor 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide receptor 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi Serotonin receptor 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.2187 0.2187
Entamoeba histolytica cyclin family protein 0.0043 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide s receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis allatostatin A receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus g protein coupled receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Echinococcus multilocularis serotonin receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Schistosoma mansoni amine GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.2187 0.2187
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) solute carrier family 6 member 4 0.0182 1 1
Brugia malayi neuropeptide F receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.2187 0.2187
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus multilocularis neuropeptide receptor 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.2187 0.2187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus allatostatin A receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Echinococcus granulosus sex peptide receptor 0.0073 0.2187 0.2187
Schistosoma mansoni amine GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni biogenic amine receptor 0.0073 0.2187 0.2187
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis g protein coupled receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi GnHR receptor homolog 0.0073 0.2187 0.2187
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.2187 0.2187
Echinococcus granulosus neuropeptide receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.2187 0.2187
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.2187 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.2187 0.2187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.7485 1
Onchocerca volvulus 0.0073 0.2187 0.2187
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 0.2187 0.2187
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0488 0.0651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.2187 0.2187
Echinococcus granulosus fmrfamide receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Echinococcus granulosus thymidylate synthase 0.0104 0.4424 0.4424
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.2187 0.2187
Brugia malayi Dopamine receptor 0.0073 0.2187 0.2187
Brugia malayi Serotonin receptor 0.0073 0.2187 0.2187
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.2187 0.2187
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.2187 0.2187
Schistosoma mansoni neuropeptide receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Brugia malayi hypothetical protein 0.0073 0.2187 0.2187
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.2187 0.2187
Loa Loa (eye worm) hypothetical protein 0.0073 0.2187 0.2187
Schistosoma mansoni amine GPCR 0.0073 0.2187 0.2187
Brugia malayi G protein-coupled receptor 0.0073 0.2187 0.2187
Schistosoma mansoni hypothetical protein 0.0073 0.2187 0.2187
Mycobacterium ulcerans thymidylate synthase 0.0104 0.4424 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.2187 0.2187

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.033 uM Compound was evaluated for inhibition of Cyclin-dependent kinase 2-cyclin E ChEMBL. 12431050
IC50 (binding) = 0.033 uM Compound was evaluated for inhibition of Cyclin-dependent kinase 2-cyclin E ChEMBL. 12431050
IC50 (binding) = 0.113 uM Compound was evaluated for 50% inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 12431050
IC50 (binding) = 0.113 uM Compound was evaluated for 50% inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 12431050

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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