Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, gamma | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.8689 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0203 | 0.7558 | 0.7558 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5235 | 0.3052 |
Brugia malayi | Protein kinase c protein 2 | 0.0188 | 0.6621 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0203 | 0.7558 | 0.7427 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0182 | 0.6207 | 0.6003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0241 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0241 | 1 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0143 | 0.3718 | 0.3718 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.7677 | 0.7965 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.015 | 0.4179 | 0.0927 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0143 | 0.3718 | 0.338 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0138 | 0.3379 | 0.3023 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0143 | 0.3718 | 0.338 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5235 | 0.3052 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0182 | 0.6207 | 0.6207 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0241 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0182 | 0.6207 | 0.6003 |
Echinococcus granulosus | protein kinase c iota type | 0.0093 | 0.0511 | 0.0511 |
Onchocerca volvulus | 0.0167 | 0.5235 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0182 | 0.6207 | 0.5007 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5235 | 0.3052 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0085 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.616 | 0.4912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Evaluated against recombinant human Protein kinase C delta | ChEMBL. | 8978850 |
IC50 (binding) | = 0.27 uM | Evaluated against recombinant human Protein kinase C delta | ChEMBL. | 8978850 |
IC50 (binding) | = 0.5 uM | Evaluated against recombinant human Protein kinase C beta 2 | ChEMBL. | 8978850 |
IC50 (binding) | = 0.5 uM | Evaluated against recombinant human Protein kinase C beta 2 | ChEMBL. | 8978850 |
IC50 (binding) | = 0.88 uM | Evaluated against recombinant human Protein kinase C beta 1 | ChEMBL. | 8978850 |
IC50 (binding) | = 0.88 uM | Evaluated against recombinant human Protein kinase C beta 1 | ChEMBL. | 8978850 |
IC50 (binding) | = 1.4 uM | Evaluated against recombinant human Protein kinase C nu | ChEMBL. | 8978850 |
IC50 (binding) | = 1.4 uM | Evaluated against recombinant human Protein kinase C nu | ChEMBL. | 8978850 |
IC50 (binding) | = 4 uM | Evaluated against recombinant human Protein kinase C alpha | ChEMBL. | 8978850 |
IC50 (binding) | = 4 uM | Evaluated against recombinant human Protein kinase C alpha | ChEMBL. | 8978850 |
IC50 (binding) | = 4.2 uM | Evaluated against recombinant human Protein kinase C gamma | ChEMBL. | 8978850 |
IC50 (binding) | = 4.2 uM | Evaluated against recombinant human Protein kinase C gamma | ChEMBL. | 8978850 |
IC50 (binding) | = 30 uM | Evaluated against recombinant human Protein kinase C epsilon | ChEMBL. | 8978850 |
IC50 (binding) | = 30 uM | Evaluated against recombinant human Protein kinase C epsilon | ChEMBL. | 8978850 |
IC50 (binding) | > 50 uM | Evaluated against recombinant human Protein Kinase A (PKA) | ChEMBL. | 8978850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.