Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.092 | 0.1464 |
Leishmania major | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Giardia lamblia | Thymidine kinase | 0.0246 | 0.6454 | 0.6454 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.3277 | 0.5214 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.1322 | 0.2103 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.1322 | 0.2103 |
Echinococcus granulosus | geminin | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1322 | 0.2103 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.024 | 0.6285 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2995 | 0.4765 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2995 | 0.4765 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4709 | 0.7492 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0246 | 0.6454 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1322 | 0.2103 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2995 | 0.4765 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.1322 | 0.2048 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thymidine kinase | 0.024 | 0.6285 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10 uM | Antiviral activity assayed by ability to inhibit Towne strain of HCMV virus | ChEMBL. | 9575044 |
IC50 (functional) | = 32 uM | Antiviral activity assayed by ability to inhibit Towne strain of HCMV virus | ChEMBL. | 9575044 |
IC50 (functional) | = 65 uM | Compound was evaluated for the cytotoxicity by the inhibition of KB cell growth. | ChEMBL. | 9575044 |
IC50 (functional) | > 100 uM | Compound was evaluated for the cytotoxicity scored on HFF cells at time of HCMV plaque enumeration. | ChEMBL. | 9575044 |
IC50 (functional) | > 100 uM | Antiviral activity evaluated by their ability to inhibit the KOS strain of herpes simplex virus type-1(HSV-1).plaque assay was used | ChEMBL. | 9575044 |
IC90 (functional) | = 2 uM | Compound was evaluated for its antibacterial activity against HCMV virus using Yield reduction assay. | ChEMBL. | 9575044 |
IC90 (functional) | = 2.8 uM | Compound was evaluated for its antibacterial activity against HCMV virus using Yield reduction assay. | ChEMBL. | 9575044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.