Detailed information for compound 258819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.463 | Formula: C20H30N2O4
  • H donors: 2 H acceptors: 3 LogP: 3.76 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H]([C@@H](C(=O)N[C@@H](CC(C)C)C=O)NC(=O)OCc1ccccc1)C
  • InChi: 1S/C20H30N2O4/c1-5-15(4)18(19(24)21-17(12-23)11-14(2)3)22-20(25)26-13-16-9-7-6-8-10-16/h6-10,12,14-15,17-18H,5,11,13H2,1-4H3,(H,21,24)(H,22,25)/t15-,17-,18-/m0/s1
  • InChiKey: WJQLUFQGNVGLKR-SZMVWBNQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calpain 1, (mu/I) large subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis calpain family protein 1, d Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Onchocerca volvulus Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus family C2 unassigned peptidase C02 family Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma japonicum Calpain-A, putative Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma japonicum Calpain-1 catalytic subunit, putative Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma japonicum ko:K08585 calpain, invertebrate, putative Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus calpain A calpain 1, (mu/I) large subunit 714 aa 753 aa 31.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0034
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0562 0.0456 0.1334
Loa Loa (eye worm) hypothetical protein 0.0174 0.0132 0.0386
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0567 0.046 0.1326
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0103 0.0297
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Echinococcus multilocularis g protein coupled receptor 0.0143 0.0107 0.0312
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0069 0.0044 0.013
Trypanosoma brucei kinesin, putative 0.0017 0.0001 0.0004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0143 0.0107 0.0312
Schistosoma mansoni Mername-AA248 (C02 family) 0.0025 0.0008 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.0171 0.0171
Onchocerca volvulus 0.0041 0.0021 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Echinococcus multilocularis thymidylate synthase 0.4111 0.3415 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0143 0.0107 0.0312
Echinococcus granulosus tm gpcr rhodopsin 0.0143 0.0107 0.0312
Brugia malayi neuropeptide F receptor 0.0143 0.0107 0.0107
Loa Loa (eye worm) calpain family protein 1 0.0048 0.0027 0.008
Schistosoma mansoni neuropeptide receptor 0.0143 0.0107 0.0312
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0038 0.0223
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0066 0.0042 0.0123
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0011 0.0011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0139 0.0103 0.0103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.0043
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0128 0.0093 0.027
Echinococcus multilocularis calpain 7 (C02 family) 0.0025 0.0008 0.0022
Echinococcus granulosus g-protein coupled receptor 0.0143 0.0107 0.0312
Brugia malayi larval opioid receptor 0.0143 0.0107 0.0107
Echinococcus granulosus muscleblind protein 0.0172 0.013 0.0381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Onchocerca volvulus 0.0059 0.0037 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0024 0.0047
Loa Loa (eye worm) hypothetical protein 0.0402 0.0322 0.0944
Loa Loa (eye worm) calpain family protein 1 0.0066 0.0042 0.0123
Brugia malayi calpain family protein 1 0.0066 0.0042 0.0042
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0005 0.0014
Onchocerca volvulus 0.0143 0.0107 0.0302
Echinococcus multilocularis serotonin receptor 0.0402 0.0322 0.0944
Schistosoma mansoni cpg binding protein 0.0035 0.0016 0.0047
Schistosoma mansoni chromobox protein 0.0061 0.0038 0.011
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0139 0.0103 0.3247
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0002 0.0005
Schistosoma mansoni biogenic amine receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0062 0.0181
Echinococcus multilocularis somatostatin receptor 0.0143 0.0107 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.002 0.0057
Onchocerca volvulus 0.0143 0.0107 0.0302
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Echinococcus granulosus G protein coupled receptor 139 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi G protein-coupled receptor F59B2.13 0.0143 0.0107 0.0107
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0143 0.0107 0.0312
Schistosoma mansoni neuropeptide receptor 0.0143 0.0107 0.0312
Schistosoma mansoni lipoxygenase 0.0128 0.0093 0.0273
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1528 0.1261 0.3677
Schistosoma mansoni hypothetical protein 0.0056 0.0034 0.0098
Schistosoma mansoni chromobox protein 0.0061 0.0038 0.011
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0014
Loa Loa (eye worm) glutaminase 2 0.0574 0.0466 0.1364
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Brugia malayi CXXC zinc finger family protein 0.0033 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0143 0.0107 0.0312
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0064 0.0041 0.0119
Brugia malayi folate-like transporter 3 0.0059 0.0037 0.0037
Trypanosoma brucei unspecified product 0.0037 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0032
Brugia malayi G-protein coupled receptor 0.0143 0.0107 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0159 0.012 0.3786
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.4111 0.3415 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0069 0.0044 0.013
Schistosoma mansoni histamine h1 receptor 0.0143 0.0107 0.0312
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0005 0.0014
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0172 0.013 0.0381
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0143 0.0107 0.0312
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0003 0.001
Brugia malayi Serotonin receptor 0.0143 0.0107 0.0107
Trypanosoma brucei calpain-like protein, putative 0.0025 0.0008 0.0022
Schistosoma mansoni hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0064 0.0041 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0015 0.0043
Schistosoma mansoni amine GPCR 0.0143 0.0107 0.0312
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0128 0.0093 0.027
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi calpain 7 0.0025 0.0008 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0143 0.0107 0.0312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.002 0.0059
Schistosoma mansoni growth hormone secretagogue receptor 0.0143 0.0107 0.0312
Echinococcus granulosus peptide allatostatin:somatostatin 0.0143 0.0107 0.0312
Onchocerca volvulus 0.0029 0.0011 0.0023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0003 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0003 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0003 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0015 0.0035
Brugia malayi polk-prov protein 0.0034 0.0015 0.0015
Echinococcus granulosus g protein coupled receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) phosphatidylinositol 3 0.05 0.0404 0.1183
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0033
Onchocerca volvulus 0.0073 0.0048 0.013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0143 0.0107 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Echinococcus multilocularis calpain 5 0.0025 0.0008 0.0022
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.002 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.002 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Brugia malayi Pre-SET motif family protein 0.0434 0.0349 0.0349
Onchocerca volvulus 0.0021 0.0005 0.0004
Echinococcus multilocularis sex peptide receptor 0.0143 0.0107 0.0312
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.1045 0.0858 0.2513
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0064 0.0041 0.0242
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0126 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.0057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis neuropeptides capa receptor 0.0143 0.0107 0.0312
Onchocerca volvulus 0.0029 0.0011 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0824 0.0674 0.4158
Brugia malayi Dopamine receptor 0.0143 0.0107 0.0107
Echinococcus multilocularis chromobox protein 1 0.0061 0.0038 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Loa Loa (eye worm) G-protein coupled receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis allatostatin A receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis serotonin receptor 0.0402 0.0322 0.0944
Schistosoma mansoni thyroid hormone receptor 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0014 0.0042
Echinococcus granulosus sex peptide receptor 0.0143 0.0107 0.0312
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.4163 0.3458 1
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0567 0.046 0.1326
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0008 0.001
Echinococcus granulosus orexin receptor type 2 0.0143 0.0107 0.0312
Onchocerca volvulus 0.0143 0.0107 0.0302
Loa Loa (eye worm) dihydrofolate reductase 0.0052 0.003 0.0088
Schistosoma mansoni neuropeptide f receptor 76f 0.0143 0.0107 0.0312
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.002 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0126 0.0092 0.0267
Echinococcus multilocularis neuropeptide FF receptor 2 0.0143 0.0107 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0402 0.0322 0.0944
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0139 0.0103 0.0297
Brugia malayi Serotonin receptor 0.0143 0.0107 0.0107
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0018 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0015 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.0043
Schistosoma mansoni lamin 0.0029 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Echinococcus granulosus calpain 0.0025 0.0008 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0003 0.001
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.4163 0.3458 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0128 0.0093 0.0273
Echinococcus multilocularis calpain family protein 1, d 0.0048 0.0027 0.008
Echinococcus multilocularis lamin dm0 0.0029 0.0011 0.0033
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0005 0.0014
Schistosoma mansoni calpain (C02 family) 0.0025 0.0008 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0024 0.0047
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0126 0.0092 0.0267
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0003 0.001
Echinococcus granulosus folate receptor beta 0.0983 0.0806 0.2361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0003 0.001
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0062 0.0039 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0003 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0494 0.0399 0.2457
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0126 0.0092 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0037 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0005 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0005 0.0014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0039 0.0115
Loa Loa (eye worm) heterochromatin protein 1 0.0061 0.0038 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0003 0.001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0143 0.0107 0.0312
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0143 0.0107 0.0312
Echinococcus granulosus g protein coupled receptor 0.0143 0.0107 0.0312
Trypanosoma brucei calpain-like protein, putative 0.0025 0.0008 0.0022
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0052 0.003 0.0088
Brugia malayi ecdysteroid receptor 0.002 0.0003 0.0003
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0044 0.013
Schistosoma mansoni hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0005 0.0014
Schistosoma mansoni dihydrofolate reductase 0.0052 0.003 0.0088
Echinococcus multilocularis muscleblind protein 1 0.0172 0.013 0.0381
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0064 0.0041 0.0242
Entamoeba histolytica calpain large subunit domain III containing protein 0.0017 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) glutaminase 0.0574 0.0466 0.1364
Echinococcus granulosus serotonin receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0128 0.0093 0.0273
Chlamydia trachomatis transglycolase/transpeptidase 0.0804 0.0658 0.447
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) reduced folate carrier family protein 0.0059 0.0037 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0402 0.0322 0.0944
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.002 0.0559
Echinococcus granulosus dihydrofolate reductase 0.0052 0.003 0.0088
Echinococcus granulosus chromobox protein 1 0.0061 0.0038 0.011
Chlamydia trachomatis transglycolase/transpeptidase 0.1768 0.1461 1
Entamoeba histolytica hypothetical protein 0.0059 0.0037 0.1154
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0062
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0126 0.0092 0.027
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0018 0.0099
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0121 0.0088 0.0256
Echinococcus granulosus neuropeptide receptor 0.0143 0.0107 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.002 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Echinococcus granulosus hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0128 0.0093 0.0273
Brugia malayi intermediate filament protein 0.0029 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus granulosus calpain A 0.0025 0.0008 0.0022
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.048 0.0387 0.1112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.0029 0.0011 0.0033
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Brugia malayi G protein-coupled receptor 0.0143 0.0107 0.0107
Brugia malayi chromobox protein homolog 3 0.0034 0.0015 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0003 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0024 0.0139
Echinococcus granulosus neuropeptide FF receptor 2 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0143 0.0107 0.0107
Schistosoma mansoni rab6-interacting 0.0021 0.0005 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0402 0.0322 0.0944
Echinococcus multilocularis calpain A 0.0069 0.0044 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0003 0.001
Loa Loa (eye worm) thymidylate synthase 0.4111 0.3415 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0081 0.0237
Onchocerca volvulus Folate transporter 1 homolog 0.0059 0.0037 0.0097
Loa Loa (eye worm) calpain 5 0.0017 0.0001 0.0004
Brugia malayi dihydrofolate reductase family protein 0.0052 0.003 0.003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0143 0.0107 0.0312
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0039 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0143 0.0107 0.0312
Brugia malayi Dihydrofolate reductase 0.0052 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0003 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Brugia malayi ORL1-like opioid receptor 0.0143 0.0107 0.0107
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.0316 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0002 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0005 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0064 0.0041 0.1281
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0064 0.0041 0.0119
Echinococcus multilocularis neuropeptide s receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0024 0.007
Schistosoma mansoni hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0003 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0143 0.0107 0.0312
Schistosoma mansoni opsin-like receptor 0.0143 0.0107 0.0312
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0003 0.001
Giardia lamblia Hypothetical protein 0.0059 0.0037 0.1249
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0112
Schistosoma mansoni adenoreceptor 0.0143 0.0107 0.0312
Echinococcus granulosus chromobox protein 1 0.0061 0.0038 0.011
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0121 0.0088 0.0256
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0064 0.0041 0.0041
Echinococcus granulosus transcription factor Dp 1 0.008 0.0054 0.0158
Schistosoma mansoni lamin 0.0029 0.0011 0.0033
Echinococcus multilocularis calpain 0.0025 0.0008 0.0022
Brugia malayi Doublecortin family protein 0.0021 0.0005 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0143 0.0107 0.0312
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1768 0.1461 1
Trypanosoma cruzi kinesin, putative 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.002 0.002
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0128 0.0093 0.027
Trichomonas vaginalis conserved hypothetical protein 0.1956 0.1618 1
Brugia malayi nuclear hormone receptor 0.002 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.0116 0.0316
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0143 0.0107 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0039 0.0115
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0039 0.0115
Onchocerca volvulus 0.0033 0.0014 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0143 0.0107 0.0312
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0088 0.0233
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Onchocerca volvulus Neuropeptide F receptor homolog 0.0143 0.0107 0.0302
Echinococcus granulosus tm gpcr rhodopsin 0.0143 0.0107 0.0312
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0003 0.001
Onchocerca volvulus 0.0143 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0016 0.0000029291 0.0000085769
Brugia malayi calpain family protein 1 0.0066 0.0042 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0003 0.001
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0088 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Schistosoma mansoni amine GPCR 0.103 0.0846 0.2477
Echinococcus granulosus intermediate filament protein 0.0029 0.0011 0.0033
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis fmrfamide receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0221 0.0171 0.0502
Leishmania major kinesin, putative 0.0017 0.0001 0.0004
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0027
Brugia malayi Pre-SET motif family protein 0.0063 0.0039 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0041 0.0094
Loa Loa (eye worm) TYRA-2 protein 0.0143 0.0107 0.0312
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis folate receptor beta 0.0983 0.0806 0.2361
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0003 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0143 0.0107 0.0312
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0143 0.0107 0.0312
Schistosoma mansoni cpg binding protein 0.0035 0.0016 0.0047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0006 0.0017
Mycobacterium ulcerans glutaminase 0.0574 0.0466 0.1344
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0143 0.0107 0.0312
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0824 0.0674 0.1954
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.0116 0.0339
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni opsin-like receptor 0.0143 0.0107 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi Dopamine receptor protein 1 0.0143 0.0107 0.0107
Brugia malayi steroid hormone receptor 0.002 0.0003 0.0003
Plasmodium vivax SET domain protein, putative 0.0063 0.0039 0.01
Echinococcus multilocularis Zinc finger, PHD finger 0.0064 0.0041 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.038 0.0304 0.9615
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0003 0.0003
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0139 0.0103 0.0301
Schistosoma mansoni biogenic amine (5HT) receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis neuropeptide Y receptor 0.0143 0.0107 0.0312
Echinococcus granulosus somatostatin receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis neuropeptides capa receptor 0.0143 0.0107 0.0312
Onchocerca volvulus 0.009 0.0062 0.0172
Echinococcus granulosus thymidylate synthase 0.4111 0.3415 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.002 0.008
Toxoplasma gondii exonuclease III APE 0.0039 0.002 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0395 0.0316 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0103 0.0297
Entamoeba histolytica protein kinase, putative 0.0017 0.0001 0.0045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0126 0.0092 0.2915
Onchocerca volvulus 0.0021 0.0005 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0003 0.001
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0064 0.0041 0.0117
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0003 0.001
Echinococcus multilocularis neuropeptide receptor 0.0143 0.0107 0.0312
Schistosoma mansoni myosin xvIII 0.0143 0.0107 0.0312
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0008 0.0023
Onchocerca volvulus 0.0143 0.0107 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0039 0.0115
Schistosoma mansoni coup transcription factor 0.002 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni loxhd1 0.0021 0.0005 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0041 0.0095
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.03 0.0237 0.1458
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Schistosoma mansoni calpain C (C02 family) 0.0025 0.0008 0.0022
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis muscleblind protein 0.0172 0.013 0.0381
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0015 0.0045
Echinococcus multilocularis neuropeptide receptor 0.0143 0.0107 0.0312
Trypanosoma brucei antigen, putative 0.0025 0.0008 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.0349 0.1021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Echinococcus granulosus tachykinin peptides receptor 99D 0.0143 0.0107 0.0312
Giardia lamblia Fructose-bisphosphate aldolase 0.0316 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0027 0.008
Schistosoma mansoni amine GPCR 0.0143 0.0107 0.0312
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0064 0.0041 0.0104
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.4163 0.3458 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0238 0.0185 0.7335
Onchocerca volvulus 0.0143 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0139 0.0103 0.0301
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0039 0.0115
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0024 0.0139
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0088 0.0256
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0011 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0042 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0064 0.0041 0.0104
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0139 0.0103 0.0301
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1956 0.1618 0.4678
Plasmodium vivax calpain, putative 0.0025 0.0008 0.0008
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0143 0.0107 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0562 0.0456 0.1334
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0395 0.0316 0.1948
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0128 0.0093 0.027
Echinococcus granulosus cpg binding protein 0.0035 0.0016 0.0047
Echinococcus multilocularis hypothetical protein 0.0025 0.0008 0.0022
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0062 0.0181
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni thyroid hormone receptor 0.002 0.0003 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0024 0.0069
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0112 0.008 0.0231
Echinococcus multilocularis RUN 0.0021 0.0005 0.0014
Echinococcus multilocularis lamin 0.0029 0.0011 0.0033
Schistosoma mansoni hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi calpain 5 0.0017 0.0001 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.002 0.0057
Brugia malayi AKH receptor 0.0143 0.0107 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0003 0.0003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0121 0.0088 0.0088
Echinococcus granulosus dna polymerase kappa 0.0044 0.0024 0.007
Entamoeba histolytica hypothetical protein 0.0333 0.0265 0.8366
Brugia malayi putative neuropeptide receptor NPR1 0.0143 0.0107 0.0107
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0077 0.0051 0.1833
Schistosoma mansoni polycystin 1-related 0.0021 0.0005 0.0014
Treponema pallidum penicillin-binding protein (pbp-1) 0.1768 0.1461 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0003 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0024 0.0069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0143 0.0107 0.0302
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0143 0.0107 0.0312
Echinococcus granulosus FTZ F1 alpha 0.002 0.0003 0.001
Brugia malayi Heterochromatin protein 1 0.0061 0.0038 0.0038
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0325 0.0258 0.0732
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0257 0.0201 0.0588
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0052 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0128 0.0093 0.0273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0039 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0018 0.0099
Onchocerca volvulus 0.0143 0.0107 0.0302
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.0316 0.0915
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.002 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Schistosoma mansoni amine GPCR 0.0143 0.0107 0.0312
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0143 0.0107 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0143 0.0107 0.0312
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Onchocerca volvulus 0.0059 0.0037 0.0097
Onchocerca volvulus 0.0059 0.0037 0.0097
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0034 0.0015 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Schistosoma mansoni glutaminase 0.0574 0.0466 0.1364
Schistosoma mansoni amine GPCR 0.0143 0.0107 0.0312
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0139 0.0103 0.0301
Brugia malayi hypothetical protein 0.0143 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0058 0.0036 0.0104
Trichomonas vaginalis glutaminase, putative 0.0574 0.0466 0.2873
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0143 0.0107 0.0312
Brugia malayi sulfakinin receptor protein 0.0143 0.0107 0.0107
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0126 0.0092 0.0561
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0000029291 0.0000085769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0003 0.001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0143 0.0107 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0003 0.001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0003 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.03 0.0237 0.1458
Loa Loa (eye worm) calpain 0.0025 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0062 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi neuropeptide F receptor 0.0143 0.0107 0.0107
Echinococcus granulosus RUN 0.0021 0.0005 0.0014
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.002 0.008
Brugia malayi Tachykinin-like peptides receptor 99D 0.0143 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0003 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0112
Schistosoma mansoni nuclear hormone receptor 0.002 0.0003 0.001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0041 0.0094
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Brugia malayi hypothetical protein 0.1956 0.1618 0.1618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.002 0.0059
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.4111 0.3415 1
Onchocerca volvulus 0.0143 0.0107 0.0302
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0143 0.0107 0.0312
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0064 0.0041 0.0117
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0052 0.003 0.0065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0006 0.0017
Brugia malayi Muscleblind-like protein 0.0172 0.013 0.013
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0044 0.013
Echinococcus granulosus lamin 0.0029 0.0011 0.0033
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0143 0.0107 0.0312
Trypanosoma brucei calpain-like protein, putative 0.0025 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.0265 0.8366
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0018 0.0052
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.008 0.0234
Brugia malayi glutaminase DH11.1 0.0574 0.0466 0.0466
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Mycobacterium tuberculosis Hypothetical protein 0.1956 0.1618 0.4737
Echinococcus multilocularis fmrfamide receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0003 0.001
Echinococcus granulosus calpain A 0.0069 0.0044 0.013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0048 0.0139
Echinococcus multilocularis neuropeptide Y receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) G-protein coupled receptor 0.0143 0.0107 0.0312
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0008 0.0024
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0143 0.0107 0.0312
Toxoplasma gondii hypothetical protein 0.0242 0.0188 0.0523
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0003 0.001
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0177 0.0134 0.0393
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0143 0.0107 0.0312
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0567 0.046 0.1346
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0128 0.0093 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0395 0.0316 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Leishmania major phosphatidylinositol 3-kinase, putative 0.0064 0.0041 0.0117
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0015 0.0043
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0103 0.0297
Brugia malayi putative neuropeptide receptor 0.0143 0.0107 0.0107
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Echinococcus granulosus fmrfamide receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0011 0.0033
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0062 0.0181
Brugia malayi Melatonin receptor type 1A 0.0143 0.0107 0.0107
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0143 0.0107 0.0312
Brugia malayi follicle stimulating hormone receptor 0.0143 0.0107 0.0107
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0395 0.0316 0.1948
Chlamydia trachomatis dihydrofolate reductase 0.0052 0.003 0.0151
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0128 0.0093 0.0273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.002 0.0059
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Treponema pallidum fructose-bisphosphate aldolase 0.0316 0.0251 0.1669
Echinococcus granulosus neuropeptide Y receptor 0.0143 0.0107 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Onchocerca volvulus 0.0143 0.0107 0.0302
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Onchocerca volvulus Folate transporter 1 homolog 0.0059 0.0037 0.0097
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0177 0.0134 0.0393
Schistosoma mansoni biogenic amine receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis dihydrofolate reductase 0.0052 0.003 0.0088
Echinococcus multilocularis transcription factor Dp 1 0.008 0.0054 0.0158
Onchocerca volvulus 0.0143 0.0107 0.0302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0003 0.001
Onchocerca volvulus 0.0143 0.0107 0.0302
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0008 0.001
Onchocerca volvulus 0.0494 0.0399 0.1158
Echinococcus granulosus neuropeptide receptor A26 0.0143 0.0107 0.0312
Echinococcus granulosus allatostatin A receptor 0.0143 0.0107 0.0312
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0008 0.0022
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0254
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.4111 0.3415 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0064 0.0041 0.0119
Onchocerca volvulus 0.0143 0.0107 0.0302
Schistosoma mansoni lipoxygenase 0.0089 0.0061 0.018
Loa Loa (eye worm) hypothetical protein 0.0221 0.0171 0.0502
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0064 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Leishmania major S-adenosylmethionine decarboxylase 0.0128 0.0093 0.027
Loa Loa (eye worm) hypothetical protein 0.0172 0.013 0.0381
Onchocerca volvulus 0.4111 0.3415 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0039 0.0115
Echinococcus granulosus calpain 5 0.0025 0.0008 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0008 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis cpg binding protein 0.0035 0.0016 0.0047
Echinococcus multilocularis neuropeptide receptor A26 0.0143 0.0107 0.0312
Loa Loa (eye worm) neuropeptide F receptor 0.0143 0.0107 0.0312
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0562 0.0456 0.1334
Echinococcus granulosus neuropeptide s receptor 0.0143 0.0107 0.0312
Onchocerca volvulus 0.0143 0.0107 0.0302
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0062 0.0039 0.0099
Brugia malayi RE15519p 0.0143 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0003 0.0003
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.1045 0.0858 0.2496
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0006 0.0017
Brugia malayi nuclear receptor NHR-88 0.002 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0029 0.0011 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0126 0.0092 0.0561
Onchocerca volvulus 0.0143 0.0107 0.0302
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0143 0.0107 0.0312
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.002 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.0251 0.7922
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.0251 0.7922
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Brugia malayi G-protein coupled receptor 0.0143 0.0107 0.0107
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.002 0.0621
Echinococcus granulosus neuropeptides capa receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0143 0.0107 0.0312
Leishmania major DNA polymerase kappa, putative 0.0023 0.0006 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.002 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0003 0.0003
Treponema pallidum penicillin-binding protein (pbp-2) 0.0824 0.0674 0.458
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0038 0.0223
Echinococcus multilocularis g protein coupled receptor 0.0143 0.0107 0.0312
Onchocerca volvulus 0.0143 0.0107 0.0302
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis g-protein coupled receptor 0.0143 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Onchocerca volvulus 0.0059 0.0037 0.0097
Mycobacterium ulcerans penicillin-binding protein PbpA 0.1045 0.0858 0.2496
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0126 0.0092 0.2915
Schistosoma mansoni opsin-like receptor 0.0143 0.0107 0.0312
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0025 0.0008 0.0022
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0128 0.0093 0.027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.0092 0.0092
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0325 0.0258 0.0732
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0143 0.0107 0.0312
Schistosoma mansoni cpg binding protein 0.0033 0.0014 0.0042
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0064 0.0041 0.0119
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0143 0.0107 0.0107
Echinococcus granulosus neuropeptide receptor 0.0143 0.0107 0.0312
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.0116 0.0316
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0008 0.0022
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0824 0.0674 0.1954
Echinococcus multilocularis chromobox protein 1 0.0061 0.0038 0.011
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0064 0.0041 0.0117
Echinococcus multilocularis G protein coupled receptor 139 0.0143 0.0107 0.0312
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0008 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0143 0.0107 0.0312
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.002 0.0034
Echinococcus granulosus g protein coupled receptor 0.0143 0.0107 0.0312
Leishmania major dihydrofolate reductase-thymidylate synthase 0.4163 0.3458 1
Onchocerca volvulus 0.0143 0.0107 0.0302
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0015 0.0086
Trypanosoma cruzi kinesin, putative 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0143 0.0107 0.0312
Schistosoma mansoni neuropeptide F-like receptor 0.0143 0.0107 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0003 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0003 0.001
Schistosoma mansoni neuropeptide receptor 0.0143 0.0107 0.0312
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0143 0.0107 0.0312
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0143 0.0107 0.0107
Loa Loa (eye worm) melatonin receptor type 1A 0.0143 0.0107 0.0312
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0003 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0003 0.001
Mycobacterium ulcerans thymidylate synthase 0.4111 0.3415 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0143 0.0107 0.0312
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.4163 0.3458 1
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0325 0.0258 0.0754
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0143 0.0107 0.0312
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0000029291 0.0000029291
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.048 0.0387 0.1133
Echinococcus granulosus tm gpcr rhodopsin 0.0143 0.0107 0.0312
Onchocerca volvulus Folate transporter 1 homolog 0.0059 0.0037 0.0097
Treponema pallidum penicillin-binding protein (pbp-3) 0.1528 0.1261 0.8619
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0143 0.0107 0.0312
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0003 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Schistosoma mansoni rab6-interacting 0.0021 0.0005 0.0014
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0064 0.0041 0.0119
Brugia malayi thymidylate synthase 0.4111 0.3415 0.3415
Echinococcus granulosus dro:myosuppressin receptor 0.0143 0.0107 0.0312
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0064 0.0041 0.1281
Trypanosoma brucei calpain-like protein, putative 0.0025 0.0008 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0003 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0000029291 0.0000029291
Schistosoma mansoni hypothetical protein 0.0176 0.0134 0.0392
Echinococcus granulosus calpain 7 C02 family 0.0025 0.0008 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0064 0.0041 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0003 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0003 0.001
Echinococcus granulosus 7tm_1 domain containing protein 0.0143 0.0107 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0395 0.0316 0.1948
Loa Loa (eye worm) hypothetical protein 0.0143 0.0107 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.0251 0.1541
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.0057
Onchocerca volvulus 0.0143 0.0107 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0047 0.0138
Echinococcus multilocularis musashi 0.0029 0.0011 0.0033
Onchocerca volvulus 0.0027 0.0009 0.0017
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0121 0.0088 0.0253
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0221 0.0171 0.0502
Brugia malayi Reduced folate carrier family protein 0.0059 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0143 0.0107 0.0312
Brugia malayi Dopamine receptor protein 2 0.0143 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0107
Echinococcus multilocularis G-protein coupled receptor, putative 0.0143 0.0107 0.0312
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.4163 0.3458 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0143 0.0107 0.0312
Schistosoma mansoni neuropeptide receptor 0.0143 0.0107 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0024 0.0069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0088 0.0233

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 41 nM Inhibitory activity evaluated against recombinant human calpain 1 ChEMBL. No reference
IC50 (binding) = 41 nM Inhibitory activity evaluated against recombinant human calpain 1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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