TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 548.673 | Formula: C31H40N4O5
H donors: 4 H acceptors: 4 LogP: 5.22 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: O=C[C@H](NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC(C)C
InChi: 1S/C31H40N4O5/c1-20(2)14-24(18-36)33-29(37)28(16-23-17-32-26-13-9-8-12-25(23)26)34-30(38)27(15-21(3)4)35-31(39)40-19-22-10-6-5-7-11-22/h5-13,17-18,20-21,24,27-28,32H,14-16,19H2,1-4H3,(H,33,37)(H,34,38)(H,35,39)/t24-,27+,28-/m1/s1
InChiKey: IDRPTFDKPPCPBD-FQLPYIGMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0099	0.4347	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0174	1	1
Schistosoma mansoni	tensin	0.0077	0.272	0.1052
Brugia malayi	Guanylate kinase family protein	0.0075	0.2576	0.0875
Echinococcus granulosus	tyrosine kinase	0.0099	0.4347	0.2856
Echinococcus granulosus	SH2 domain containing protein 7	0.0077	0.272	0.0799
Loa Loa (eye worm)	p53BP2	0.0075	0.2576	0.2576
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0099	0.4347	0.4012
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0075	0.2576	0.2135
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Brugia malayi	protein-tyrosine kinase	0.0099	0.4347	0.3052
Echinococcus multilocularis		0.0077	0.272	0.2287
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0075	0.2576	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0174	1	1
Trypanosoma brucei	conserved protein	0.0075	0.2576	0.5
Schistosoma mansoni	vav2	0.0077	0.272	0.1052
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.4203	0.2875
Loa Loa (eye worm)	guanylate kinase	0.0075	0.2576	0.2576
Onchocerca volvulus	Putative cortactin	0.0075	0.2576	0.5925
Schistosoma mansoni	tensin-related	0.0077	0.272	0.1052
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0077	0.272	0.272
Entamoeba histolytica	SH2 domain containing protein	0.0077	0.272	0.0812
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0174	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0077	0.272	0.1052
Echinococcus granulosus	Spectrin alpha actinin	0.0075	0.2576	0.0617
Echinococcus granulosus	SHC transforming protein 3	0.0077	0.272	0.0799
Echinococcus multilocularis	SH2 motif	0.0077	0.272	0.2287
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Echinococcus granulosus	tyrosine protein kinase shark	0.0099	0.4347	0.2856
Echinococcus granulosus	SH2 motif	0.0077	0.272	0.0799
Echinococcus multilocularis	transfer RNA-Ala	0.0075	0.2576	0.2135
Echinococcus granulosus	c src tyrosine kinase	0.0174	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0174	1	1
Brugia malayi	Protein kinase domain containing protein	0.0099	0.4347	0.3052
Loa Loa (eye worm)	thyroid receptor interactor	0.0075	0.2576	0.2576
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Brugia malayi	Protein kinase domain containing protein	0.0099	0.4347	0.3052
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0077	0.272	0.1052
Schistosoma mansoni	growth factor receptor-bound protein	0.0152	0.8373	0.8
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0075	0.2576	0.5925
Loa Loa (eye worm)	calpain family protein 1	0.0066	0.1864	0.1864
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Echinococcus granulosus	growth factor receptor bound protein 2	0.0152	0.8373	0.7943
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0077	0.272	0.2287
Echinococcus granulosus	nostrin	0.0075	0.2576	0.0617
Brugia malayi	Variant SH3 domain containing protein	0.0077	0.272	0.1052
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus granulosus	expressed protein	0.0075	0.2576	0.0617
Brugia malayi	Variant SH3 domain containing protein	0.0077	0.272	0.1052
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0075	0.2576	0.0875
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0099	0.4347	0.2856
Onchocerca volvulus		0.0077	0.272	0.6256
Schistosoma mansoni	hypothetical protein	0.0077	0.272	0.1052
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0075	0.2576	0.0617
Onchocerca volvulus		0.0099	0.4347	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0077	0.272	0.6256
Echinococcus multilocularis	NCK adaptor protein	0.0152	0.8373	0.8276
Brugia malayi	SH3 domain containing protein	0.0075	0.2576	0.0875
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0099	0.4347	0.4012
Onchocerca volvulus		0.0075	0.2576	0.5925
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0174	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0152	0.8373	0.8
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0077	0.272	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus multilocularis	c src tyrosine kinase	0.0174	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Schistosoma mansoni	shc transforming protein	0.0077	0.272	0.1052
Onchocerca volvulus		0.0099	0.4347	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0077	0.272	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Echinococcus granulosus	hypothetical protein	0.0077	0.272	0.0799
Schistosoma mansoni	tensin	0.0077	0.272	0.1052
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Loa Loa (eye worm)	protein-tyrosine kinase	0.0075	0.2576	0.2576
Schistosoma mansoni	suppressor of cytokine signaling	0.0077	0.272	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Onchocerca volvulus		0.0077	0.272	0.6256
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0174	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0099	0.4347	0.2856
Schistosoma mansoni	dreadlocks/dock	0.0075	0.2576	0.0875
Brugia malayi	Protein kinase domain containing protein	0.0099	0.4347	0.3052
Brugia malayi	SH2 domain containing protein	0.0099	0.4347	0.3052
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0075	0.2576	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Schistosoma mansoni	eps8-related protein	0.0075	0.2576	0.0875
Brugia malayi	Protein kinase domain containing protein	0.0099	0.4347	0.3052
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.2576	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0077	0.272	0.2287
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0075	0.2576	0.0617
Brugia malayi	Variant SH3 domain containing protein	0.0152	0.8373	0.8
Schistosoma mansoni	adapter molecule crk	0.0152	0.8373	0.8
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0077	0.272	0.2287
Schistosoma mansoni	signal transduction protein lnk-related	0.0077	0.272	0.1052
Echinococcus granulosus	expressed conserved protein	0.0077	0.272	0.0799
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0075	0.2576	0.5
Schistosoma mansoni	cell polarity protein	0.0075	0.2576	0.0875
Echinococcus multilocularis	SH2 motif	0.0077	0.272	0.2287
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0077	0.272	0.2287
Entamoeba histolytica	protein kinase, putative	0.0077	0.272	0.0812
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0075	0.2576	0.2135
Echinococcus multilocularis	nostrin	0.0075	0.2576	0.2135
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0174	1	1
Brugia malayi	SH2 domain containing protein	0.0099	0.4347	0.3052
Brugia malayi	Tensin	0.0077	0.272	0.1052
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0077	0.272	0.2287
Echinococcus granulosus	signal transduction protein lnk realted	0.0077	0.272	0.0799
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0174	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	1	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0077	0.272	0.1052
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0099	0.4347	0.4012
Schistosoma mansoni	SH2A	0.0077	0.272	0.1052
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0077	0.272	0.1052
Loa Loa (eye worm)	SRC-1	0.0174	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0075	0.2576	0.2576
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0174	1	1
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0075	0.2576	0.0617
Schistosoma mansoni	tyrosine kinase	0.0174	1	1
Schistosoma mansoni	dynamin-associated protein	0.0075	0.2576	0.0875
Echinococcus multilocularis	tensin	0.0077	0.272	0.2287
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Echinococcus multilocularis	calpain A	0.0069	0.2088	0.1618
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0075	0.2576	0.0617
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0077	0.272	0.6256
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Schistosoma mansoni	C-fyn	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0077	0.272	0.0799
Schistosoma mansoni	sorting nexin	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Brugia malayi	Src substrate cortactin	0.0075	0.2576	0.0875
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0174	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0077	0.272	0.0799
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.2088	0.0275
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0152	0.8373	0.8
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Onchocerca volvulus		0.0077	0.272	0.6256
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0077	0.272	0.2287
Brugia malayi	hypothetical protein	0.0099	0.4347	0.3052
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.2088	0.0275
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Schistosoma mansoni	GTPase activating protein	0.0077	0.272	0.1052
Echinococcus granulosus	src region	0.0075	0.2576	0.0617
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0077	0.272	0.2287
Loa Loa (eye worm)	hypothetical protein	0.0152	0.8373	0.8373
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Echinococcus multilocularis	N chimaerin	0.0077	0.272	0.2287
Schistosoma mansoni	tyrosine kinase	0.0174	1	1
Echinococcus granulosus	intersectin 2	0.0075	0.2576	0.0617
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0077	0.272	0.0799
Schistosoma mansoni	tensin	0.0077	0.272	0.1052
Onchocerca volvulus		0.0075	0.2576	0.5925
Trichomonas vaginalis	p67phox protein, putative	0.0075	0.2576	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1304	0.1304
Loa Loa (eye worm)	TK protein kinase	0.0099	0.4347	0.4347
Schistosoma mansoni	nck2/grb4	0.0152	0.8373	0.8
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0174	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Loa Loa (eye worm)	SH2 domain-containing protein	0.0077	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0174	1	1
Onchocerca volvulus		0.0077	0.272	0.6256
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0069	0.2088	0.1618
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0075	0.2576	0.0875
Brugia malayi	hypothetical protein	0.0077	0.272	0.1052
Echinococcus granulosus	endophilin A3	0.0075	0.2576	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0075	0.2576	0.2135
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0174	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Echinococcus granulosus	tyrosine protein kinase Blk	0.0099	0.4347	0.2856
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0174	1	1
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0075	0.2576	0.0617
Schistosoma mansoni	suppressor of cytokine signaling	0.0077	0.272	0.1052
Echinococcus multilocularis	endophilin A3	0.0075	0.2576	0.2135
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0077	0.272	0.2287
Onchocerca volvulus		0.0099	0.4347	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus multilocularis	tyrosine protein kinase shark	0.0099	0.4347	0.4012
Schistosoma mansoni	sorbin	0.0075	0.2576	0.0875
Leishmania major	hypothetical protein, conserved	0.0075	0.2576	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0174	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus granulosus	N chimaerin	0.0077	0.272	0.0799
Echinococcus granulosus	tyrosine kinase	0.0099	0.4347	0.2856
Echinococcus multilocularis	tyrosine kinase	0.0099	0.4347	0.4012
Echinococcus multilocularis	Spectrin alpha actinin	0.0075	0.2576	0.2135
Echinococcus multilocularis	SH2 motif	0.0077	0.272	0.2287
Onchocerca volvulus		0.0099	0.4347	1
Schistosoma mansoni	run and tbc1 domain containing	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Echinococcus multilocularis	SH2 domain containing protein 7	0.0077	0.272	0.2287
Onchocerca volvulus		0.0075	0.2576	0.5925
Loa Loa (eye worm)	STAT protein	0.0077	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Onchocerca volvulus		0.0075	0.2576	0.5925
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0077	0.272	0.272
Onchocerca volvulus		0.0077	0.272	0.6256
Echinococcus multilocularis	SHC transforming protein 3	0.0077	0.272	0.2287
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0075	0.2576	0.0875
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0077	0.272	0.0799
Echinococcus multilocularis	expressed protein	0.0075	0.2576	0.2135
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0077	0.272	0.1052
Brugia malayi	Peripheral plasma membrane protein CASK	0.0075	0.2576	0.0875
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0077	0.272	0.0799
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0077	0.272	0.0799
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0174	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0174	1	1
Brugia malayi	Protein kinase domain containing protein	0.0099	0.4347	0.3052
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Schistosoma mansoni	formin binding protein and related proteins	0.0075	0.2576	0.0875
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0075	0.2576	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Brugia malayi	Myosin tail family protein	0.0075	0.2576	0.0875
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0152	0.8373	0.8276
Onchocerca volvulus		0.0099	0.4347	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0077	0.272	0.0799
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0099	0.4347	0.4012
Onchocerca volvulus		0.0099	0.4347	1
Schistosoma mansoni	hypothetical protein	0.0077	0.272	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1864	0.1864
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0075	0.2576	0.0617
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0077	0.272	0.272
Loa Loa (eye worm)	TK/FER protein kinase	0.0099	0.4347	0.4347
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0174	1	1
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0075	0.2576	0.0875
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0075	0.2576	0.0875
Echinococcus granulosus	NCK adaptor protein	0.0152	0.8373	0.7943
Loa Loa (eye worm)	SH2 domain-containing protein	0.0077	0.272	0.272
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0077	0.272	0.1052
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0099	0.4347	0.2856
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.2576	0.5
Schistosoma mansoni	apoptosis stimulating of P53	0.0075	0.2576	0.0875
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0174	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0174	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0174	1	1
Schistosoma mansoni	hypothetical protein	0.0075	0.2576	0.0875
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0077	0.272	0.1052
Brugia malayi	Variant SH3 domain containing protein	0.0152	0.8373	0.8
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0152	0.8373	0.8373
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0077	0.272	0.0799
Echinococcus granulosus	SH2 motif	0.0077	0.272	0.0799
Schistosoma mansoni	Dab2-interacting protein-like	0.0075	0.2576	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2576	0.5
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0075	0.2576	0.0617
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.2576	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0099	0.4347	0.2856
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0075	0.2576	0.2576
Schistosoma mansoni	tyrosine kinase	0.0099	0.4347	0.3052
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0077	0.272	0.0799
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0077	0.272	0.272
Onchocerca volvulus		0.0075	0.2576	0.5925
Brugia malayi	SRC-1	0.0174	1	1
Echinococcus multilocularis	intersectin 2	0.0075	0.2576	0.2135
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0152	0.8373	0.8373
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0075	0.2576	0.2135
Onchocerca volvulus		0.0077	0.272	0.6256
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0077	0.272	0.2287
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0077	0.272	0.2287
Loa Loa (eye worm)	TK/ABL protein kinase	0.0099	0.4347	0.4347
Brugia malayi	protein-tyrosine kinase	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Schistosoma mansoni	tensin-related	0.0077	0.272	0.1052
Schistosoma mansoni	growth factor receptor-bound protein	0.0152	0.8373	0.8
Echinococcus granulosus	tensin	0.0077	0.272	0.0799
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4347	0.4347
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0075	0.2576	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2576	0.2576
Loa Loa (eye worm)	SH2 domain-containing protein	0.0077	0.272	0.272
Echinococcus multilocularis	tensin	0.0077	0.272	0.2287
Brugia malayi	SH2 domain containing protein	0.0077	0.272	0.1052
Brugia malayi	RhoGAP domain containing protein	0.0077	0.272	0.1052
Brugia malayi	Variant SH3 domain containing protein	0.0075	0.2576	0.0875
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.056	0.056
Schistosoma mansoni	hypothetical protein	0.0075	0.2576	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0077	0.272	0.272
Brugia malayi	Spectrin alpha chain	0.0075	0.2576	0.0875
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0099	0.4347	0.4012
Schistosoma mansoni	tyrosine kinase	0.0099	0.4347	0.3052

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 45 nM	Inhibitory activity evaluated against recombinant human calpain 1	ChEMBL.	No reference
IC50 (binding)	= 45 nM	Inhibitory activity evaluated against recombinant human calpain 1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 258899