Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.8067 | 0.7874 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0014 | 0.0911 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0047 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 0.8067 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0047 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.003 | 0.5244 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.1772 | 0.0947 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.003 | 0.5244 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1477 | 0.0623 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0047 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.003 | 0.5244 | 0.4767 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.003 | 0.5244 | 0.422 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.2686 | 0.1953 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.5381 | 0.4918 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.003 | 0.5244 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0017 | 0.1772 | 0.1772 |
Brugia malayi | polk-prov protein | 0.003 | 0.5381 | 0.4918 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0047 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.003 | 0.5244 | 0.422 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5381 | 0.4918 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.6292 | 0.592 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.8067 | 0.7874 |
Toxoplasma gondii | methionine aminopeptidase | 0.003 | 0.5244 | 0.5244 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.003 | 0.5244 | 0.5244 |
Trypanosoma brucei | unspecified product | 0.0033 | 0.6292 | 0.592 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.2686 | 0.4098 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.2686 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 0.8067 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.003 | 0.5244 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1477 | 0.0623 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.1772 | 0.0947 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Chlamydia trachomatis | methionine aminopeptidase | 0.003 | 0.5244 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Leishmania major | hypothetical protein, conserved | 0.0017 | 0.1772 | 0.0947 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.2686 | 0.1953 |
Toxoplasma gondii | methionine aminopeptidase | 0.0047 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.003 | 0.5244 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.004 | 0.8067 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.5381 | 0.4918 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0047 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0047 | 1 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0047 | 1 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0047 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0047 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.2686 | 0.1953 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.8067 | 0.7874 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1477 | 0.0623 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.8067 | 0.7874 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0017 | 0.1772 | 0.0947 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.003 | 0.5244 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.004 | 0.8067 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.003 | 0.5244 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.003 | 0.5244 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 11 % | Percent inhibition of SRS-A induced contraction minus percent inhibition of 25 mM KCl induced contractions at a conc of 50(microM) | ChEMBL. | 7143363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.