Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1711 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1413 | 0.1413 |
Echinococcus granulosus | acetylcholinesterase | 0.1711 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1413 | 0.1413 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0289 | 0.1413 | 0.1413 |
Onchocerca volvulus | 0.0289 | 0.1413 | 1 | |
Onchocerca volvulus | 0.0289 | 0.1413 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Echinococcus multilocularis | neuroligin | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Brugia malayi | Carboxylesterase family protein | 0.1711 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0289 | 0.1413 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0067 | 0.0075 | 0.0075 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Schistosoma mansoni | amine GPCR | 0.0566 | 0.3083 | 0.3083 |
Onchocerca volvulus | 0.0289 | 0.1413 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0289 | 0.1413 | 0.1413 |
Echinococcus multilocularis | acetylcholinesterase | 0.1711 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0289 | 0.1413 | 0.1413 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0289 | 0.1413 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | carboxylesterase | 0.0289 | 0.1413 | 0.1413 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0289 | 0.1413 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0289 | 0.1413 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1413 | 0.1413 |
Schistosoma mansoni | gliotactin | 0.0289 | 0.1413 | 0.1413 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0289 | 0.1413 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | carboxylesterase | 0.1711 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | carboxylesterase | 0.0289 | 0.1413 | 0.1413 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0289 | 0.1413 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1711 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1711 | 1 | 1 |
Onchocerca volvulus | 0.0289 | 0.1413 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1711 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1711 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0289 | 0.1413 | 0.1413 |
Brugia malayi | Cytochrome P450 family protein | 0.0067 | 0.0075 | 0.0075 |
Onchocerca volvulus | 0.0289 | 0.1413 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1711 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0289 | 0.1413 | 0.1413 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 143 nM | Inhibitory activity against 20-HETE production from arachidonic acid using human renal microsome 20-HETE synthase. | ChEMBL. | 14640550 |
IC50 (binding) | = 360 nM | Concentration required to inhibit cytochrome P450 19A1. | ChEMBL. | 14640550 |
IC50 (binding) | = 360 nM | Concentration required to inhibit cytochrome P450 19A1. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 386 nM | Concentration required to inhibit cytochrome P450 1A2. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 386 nM | Concentration required to inhibit cytochrome P450 1A2. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 6880 nM | Concentration required to inhibit cytochrome P450 2C9. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 6880 nM | Concentration required to inhibit cytochrome P450 2C9. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 7810 nM | Concentration required to inhibit cytochrome P450 2D6. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 7810 nM | Concentration required to inhibit cytochrome P450 2D6. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 9170 nM | Concentration required to inhibit cytochrome P450 3A4. | ChEMBL. | 14640550 |
IC50 (ADMET) | = 9170 nM | Concentration required to inhibit cytochrome P450 3A4. | ChEMBL. | 14640550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.