Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.5612 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0323 | 0.4693 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0644 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.3928 | 0.8862 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0112 | 0.1211 | 0.2626 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0248 | 0.3469 | 0.6211 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | Tolloid protein 1 | 0.0112 | 0.1211 | 0.6463 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1308 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0068 | 0.000000064246 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.4003 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2473 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1875 | 0.7661 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0255 | 0.0431 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0068 | 0.000000045149 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.3928 | 0.8345 |
Brugia malayi | Fibulin-1 precursor | 0.0112 | 0.1211 | 0.2473 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0112 | 0.1211 | 0.2473 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0372 | 0.5503 | 0.2188 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | notch | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0048 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.9714 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.3928 | 0.7113 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1237 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.1028 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.6077 |
Echinococcus multilocularis | notch | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.075 | 0.1769 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.3067 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.409 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.075 | 0.1568 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0112 | 0.1211 | 0.2626 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.7932 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.1487 | 0.3258 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.032 | 0.0654 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0112 | 0.1211 | 0.4951 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.5443 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0112 | 0.1211 | 0.4951 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2838 | 0.5989 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1211 | 0.3519 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.3928 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0248 | 0.3469 | 0.4857 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.3928 | 0.8862 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.1487 | 0.5 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0372 | 0.5503 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1875 | 0.4681 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | laminin | 0.0112 | 0.1211 | 0.6463 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.0464 | 0.0858 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.2422 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.2447 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0641 | 0.9962 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3318 | 0.5995 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.1332 | 0.3275 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0068 | 0.000000045149 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.3928 | 0.3914 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.5388 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.2477 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1487 | 0.3677 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4243 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1487 | 0.3258 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.075 | 0.1476 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0123 | 0.1396 | 0.2122 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0068 | 0.0276 |
Onchocerca volvulus | 0.0129 | 0.1487 | 0.4366 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.000000047947 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.0502 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0641 | 0.9962 | 0.9933 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0068 | 0.000000064246 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1898 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2838 | 0.636 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2626 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1746 | 0.1714 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4391 | 0.9926 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1875 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0112 | 0.1211 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.032 | 0.0546 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0112 | 0.1211 | 0.2964 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.036 |
Onchocerca volvulus | 0.0084 | 0.075 | 0.2101 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.7104 |
Echinococcus multilocularis | laminin | 0.0112 | 0.1211 | 0.4951 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0372 | 0.5503 | 0.5502 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0068 | 0.0276 |
Onchocerca volvulus | 0.0239 | 0.3318 | 1 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.1487 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.0911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.5503 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0644 | 1 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0048 | 0.0195 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.2814 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1707 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0248 | 0.3469 | 0.3451 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.1513 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.1487 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0739 | 0.1739 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 1.59 % | Binding affinity to thyroxine binding globulin (unknown origin) relative to T4 | ChEMBL. | 195056 |
Relative ED50 (functional) | = 108 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 139 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 108 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 139 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 44.1 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 56 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 44.1 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 56 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.