Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | Prolyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania braziliensis | threonyl-tRNA synthetase, putative | Prolyl-tRNA synthetase | 575 aa | 501 aa | 18.4 % |
Leishmania donovani | threonyl-tRNA synthetase, putative | Prolyl-tRNA synthetase | 575 aa | 498 aa | 18.3 % |
Leishmania major | threonyl-tRNA synthetase, putative | Prolyl-tRNA synthetase | 575 aa | 477 aa | 18.2 % |
Leishmania mexicana | threonyl-tRNA synthetase, putative | Prolyl-tRNA synthetase | 575 aa | 482 aa | 18.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | proline--tRNA ligase, putative | 0.0038 | 0.6929 | 1 |
Mycobacterium tuberculosis | Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) | 0.0034 | 0.5695 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.002 | 0.2118 | 1 |
Giardia lamblia | Prolyl-tRNA synthetase | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5907 | 0.5907 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0036 | 0.6362 | 0.6362 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.5907 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.8785 | 0.8785 |
Brugia malayi | TAR-binding protein | 0.005 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.2118 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0036 | 0.6362 | 0.6362 |
Brugia malayi | probable proline-trna synthetase - fission yeast, putative | 0.0045 | 0.8785 | 0.8785 |
Giardia lamblia | Glycyl-tRNA synthetase | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0036 | 0.6362 | 0.6362 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.5907 | 1 |
Echinococcus granulosus | prolyl tRNA synthetase mitochondrial | 0.0038 | 0.6929 | 0.6929 |
Schistosoma mansoni | prolyl-tRNA synthetase | 0.0038 | 0.6929 | 0.6929 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.2118 | 1 |
Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | prolyl-tRNA synthetase | 0.0045 | 0.8785 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.2118 | 0.3057 |
Echinococcus multilocularis | prolyl tRNA synthetase, mitochondrial | 0.0038 | 0.6929 | 0.6929 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0036 | 0.6362 | 0.6362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0036 | 0.6362 | 0.6362 |
Treponema pallidum | prolyl-tRNA synthetase | 0.0045 | 0.8785 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.5907 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0036 | 0.6362 | 0.6362 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.2118 | 1 |
Brugia malayi | Met-10+ like-protein | 0.0034 | 0.5695 | 0.5695 |
Brugia malayi | RNA recognition motif domain containing protein | 0.005 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.2118 | 0.2118 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.2118 | 0.3057 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.005 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0034 | 0.5907 | 0.5907 |
Loa Loa (eye worm) | RNA binding protein | 0.005 | 1 | 1 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 1 | 1 |
Plasmodium vivax | proline--tRNA ligase, putative | 0.0038 | 0.6929 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.002 | 0.2118 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0034 | 0.5907 | 0.5907 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0034 | 0.5907 | 0.5907 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.005 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.5907 | 0.5907 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.002 | 0.2118 | 0.3057 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.2118 | 0.2118 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0272 | 0.0272 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.5907 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0036 | 0.6362 | 0.6362 |
Loa Loa (eye worm) | TAR-binding protein | 0.005 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.005 | 1 | 1 |
Chlamydia trachomatis | proline--tRNA ligase | 0.0045 | 0.8785 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0036 | 0.6362 | 0.6362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0036 | 0.6362 | 0.6362 |
Wolbachia endosymbiont of Brugia malayi | prolyl-tRNA synthetase | 0.0045 | 0.8785 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 uM | Aminoacylation activity against Candida albicans prolyl-tRNA synthetase | ChEMBL. | 11229766 |
IC50 (binding) | = 1.5 uM | Aminoacylation activity against Candida albicans prolyl-tRNA synthetase | ChEMBL. | 11229766 |
IC50 (binding) | > 100 uM | Aminoacylation activity against human prolyl-tRNA synthetase | ChEMBL. | 11229766 |
IC50 (binding) | > 100 uM | Aminoacylation activity against human prolyl-tRNA synthetase | ChEMBL. | 11229766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.