Detailed information for compound 259158

Basic information

Technical information
  • TDR Targets ID: 259158
  • Name: [4-(4-pyridin-2-ylpiperazin-1-yl)pyrimidin-2- yl]methanol
  • MW: 271.318 | Formula: C14H17N5O
  • H donors: 1 H acceptors: 4 LogP: 0.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1nccc(n1)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C14H17N5O/c20-11-12-15-6-4-14(17-12)19-9-7-18(8-10-19)13-3-1-2-5-16-13/h1-6,20H,7-11H2
  • InChiKey: OOJFYUSSPRODQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[4-(2-pyridyl)piperazin-1-yl]pyrimidin-2-yl]methanol
  • [4-[4-(2-pyridyl)-1-piperazinyl]-2-pyrimidinyl]methanol
  • [4-[4-(2-pyridyl)piperazino]pyrimidin-2-yl]methanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sorbitol dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short-chain dehydrogenase Get druggable targets OG5_126928 All targets in OG5_126928
Entamoeba histolytica NADP-dependent alcohol dehydrogenase Get druggable targets OG5_126928 All targets in OG5_126928
Leishmania braziliensis d-xylulose reductase, putative Get druggable targets OG5_126928 All targets in OG5_126928
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126928 All targets in OG5_126928
Leishmania infantum d-xylulose reductase, putative Get druggable targets OG5_126928 All targets in OG5_126928
Candida albicans likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL061W and BDH1 (YAL060W) butanediol dehydrogenase Get druggable targets OG5_126928 All targets in OG5_126928
Leishmania donovani d-xylulose reductase, putative Get druggable targets OG5_126928 All targets in OG5_126928
Leishmania mexicana d-xylulose reductase, putative Get druggable targets OG5_126928 All targets in OG5_126928
Leishmania major d-xylulose reductase, putative Get druggable targets OG5_126928 All targets in OG5_126928
Candida albicans similar to P.stipitis xylitol dehydrogenase (XYL2), and to S. cerevisiae SOR1 (YJR159W) sorbitol dehydrogenase Get druggable targets OG5_126928 All targets in OG5_126928
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) sorbitol dehydrogenase 357 aa 355 aa 25.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0022
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0064 0.2576 0.2533
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0245 0.0245
Trypanosoma cruzi aldo/keto reductase, putative 0.0221 1 1
Brugia malayi nuclear hormone receptor 0.001 0.0022 0.0022
Trichomonas vaginalis aldo/keto reductase, putative 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0058
Entamoeba histolytica aldose reductase, putative 0.0221 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0221 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0245 0.0245
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0221 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0343 0.0343
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0011 0.0058 0.0058
Schistosoma mansoni pol-related 0.0221 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0221 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0064 0.2576 0.2576
Loa Loa (eye worm) oxidoreductase 0.0221 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0022 0.0022
Brugia malayi Alcohol dehydrogenase class III 0.0011 0.0058 0.0058
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.2576 0.2533
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0022
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0221 1 1
Schistosoma mansoni zinc binding dehydrogenase 0.0011 0.0058 0.0058
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.2576 0.2533
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.1708 0.1708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Onchocerca volvulus 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.0221 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0343 0.0343
Echinococcus multilocularis voltage gated potassium channel subunit 0.0064 0.2576 0.2576
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.1708 0.1708
Schistosoma mansoni aldo-keto reductase 0.0221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.2576 0.2533
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.1364 0.1364
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Schistosoma mansoni coup transcription factor 0.001 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0017 0.0343 0.0343
Trichomonas vaginalis aldo/keto reductase, putative 0.0221 1 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0022 0.0022
Echinococcus granulosus tyrosine kinase 0.0038 0.1364 0.1364
Echinococcus granulosus FTZ F1 alpha 0.001 0.0022 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0022 0.0022
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0221 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0064 0.2576 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0022 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Onchocerca volvulus 0.0064 0.2576 0.2576
Echinococcus multilocularis aldo keto reductase 0.0221 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0221 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0058
Loa Loa (eye worm) oxidoreductase 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Echinococcus multilocularis aldehyde reductase 0.0157 0.6973 0.6973
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0245 0.0245
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0022 0.0022
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0064 0.2576 0.2533
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Loa Loa (eye worm) oxidoreductase 0.0221 1 1
Echinococcus multilocularis aldo keto reductase 0.0221 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Schistosoma mansoni tyrosine kinase 0.0046 0.1708 0.1708
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Onchocerca volvulus 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0011 0.0058 0.0058
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.0245
Entamoeba histolytica aldose reductase, putative 0.0221 1 1
Leishmania major aldo-keto reductase-like protein 0.0221 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Loa Loa (eye worm) oxidoreductase 0.0221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Brugia malayi NADH-dependent xylose reductase 0.0064 0.2576 0.2576
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0022 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0022 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0022 0.0022
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.1708 0.1708
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0022 0.0022
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.1364 0.1364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0022
Toxoplasma gondii aldose reductase, putative 0.0221 1 1
Echinococcus granulosus aldo keto reductase 0.0221 1 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0022
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0067 0.2709 0.2709
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Echinococcus multilocularis aldo keto reductase 0.0221 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.1708 0.1708
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0064 0.2576 0.2576
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0011 0.0058 0.0058
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Onchocerca volvulus 0.0221 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0022
Mycobacterium ulcerans short-chain dehydrogenase 0.0067 0.2709 0.2666
Brugia malayi protein-tyrosine kinase 0.0038 0.1364 0.1364
Entamoeba histolytica protein kinase, putative 0.0031 0.1012 0.1012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0011 0.0058 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0022
Mycobacterium tuberculosis Conserved protein 0.0064 0.2576 0.2533
Echinococcus multilocularis aldo keto reductase 0.0221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0022
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0022
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0245 0.0245
Trypanosoma brucei aldo-keto reductase, putative 0.0221 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0022 0.0022
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0245 0.0245
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0031 0.1012 0.1012
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.1708 0.1708
Trypanosoma cruzi aldo-keto reductase 0.0221 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.1265 0.1265
Entamoeba histolytica aldose reductase, putative 0.0221 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.1708 0.1708
Onchocerca volvulus 0.0221 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0343 0.0343
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0022
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0011 0.0058 0.0058
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0343 0.0343
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0011 0.0058 0.0058
Brugia malayi nuclear receptor NHR-88 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.1364 0.1364
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0022 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Onchocerca volvulus 0.0221 1 1
Echinococcus granulosus aldehyde reductase 0.0157 0.6973 0.6973
Echinococcus granulosus aldo keto reductase 0.0221 1 1
Loa Loa (eye worm) oxidoreductase 0.0221 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.1708 0.1708
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0064 0.2576 0.2533
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0022
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0245 0.0245
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0221 1 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0011 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0022 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.2576 0.2533
Mycobacterium leprae Possible oxidoreductase 0.0064 0.2576 0.2533
Echinococcus granulosus voltage gated potassium channel subunit 0.0064 0.2576 0.2576
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Leishmania major d-xylulose reductase, putative 0.0067 0.2709 0.2666
Brugia malayi steroid hormone receptor 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0046 0.1708 0.1708
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Echinococcus granulosus NCK adaptor protein 0.0015 0.0245 0.0245
Echinococcus granulosus hypothetical protein 0.0221 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Echinococcus granulosus aldo keto reductase 0.0221 1 1
Brugia malayi SRC-1 0.0046 0.1708 0.1708
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0022 0.0022
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0245 0.0245
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0022
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.1364 0.1364
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.1708 0.1708
Plasmodium falciparum aldehyde reductase, putative 0.0064 0.2576 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Onchocerca volvulus 0.0221 1 1
Loa Loa (eye worm) TK protein kinase 0.0038 0.1364 0.1364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0022
Giardia lamblia Aldose reductase 0.0221 1 0.5
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0221 1 1
Onchocerca volvulus 0.0221 1 1
Onchocerca volvulus Putative alcohol dehydrogenase 0.0011 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0022
Schistosoma mansoni potassium channel beta 0.0064 0.2576 0.2576
Schistosoma mansoni alcohol dehydrogenase 0.0011 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.1708 0.1708
Schistosoma mansoni tyrosine kinase 0.0017 0.0343 0.0343
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0064 0.2576 0.2533
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0064 0.2576 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.1012 0.1012
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0221 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Entamoeba histolytica alcohol dehydrogenase, putative 0.0064 0.2576 0.2576
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0343 0.0343
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0022 0.0022
Onchocerca volvulus 0.001 0.0022 0.0022
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0011 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0022
Mycobacterium leprae Conserved hypothetical protein 0.0157 0.6973 0.6955
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0022
Mycobacterium ulcerans oxidoreductase 0.0221 1 1
Schistosoma mansoni aldo-keto reductase 0.0221 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0245 0.0245
Brugia malayi ecdysteroid receptor 0.001 0.0022 0.0022
Plasmodium vivax aldehyde reductase, putative 0.0064 0.2576 0.5
Schistosoma mansoni adapter molecule crk 0.0015 0.0245 0.0245
Trypanosoma brucei prostaglandin f synthase 0.0221 1 1
Trypanosoma brucei aldo/keto reductase, putative 0.0064 0.2576 0.2533
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0067 0.2709 0.2709
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0221 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1708 0.1708
Leishmania major prostaglandin f synthase, putative 0.0221 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.1708 0.1708
Loa Loa (eye worm) SRC-1 0.0046 0.1708 0.1708
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0221 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0064 0.2576 0.2576
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0022 0.0022
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0064 0.2576 0.2576
Schistosoma mansoni nck2/grb4 0.0015 0.0245 0.0245
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.1708 0.1708
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0022 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0022 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.1364 0.1364
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.2576 0.2533
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0221 1 1
Mycobacterium ulcerans hypothetical protein 0.0064 0.2576 0.2533
Toxoplasma gondii aldo-keto reductase 0.0064 0.2576 0.2533
Giardia lamblia Aldose reductase 0.0221 1 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0245 0.0245
Trichomonas vaginalis aldo-keto reductase, putative 0.0221 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0221 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.1012 0.1012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0022 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0022

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 uM Concentration required for 50% in vitro inhibition in sheep liver sorbitol dehydrogenase (s-SDH) ChEMBL. 11784155
IC50 (binding) = 3 uM Concentration required for 50% in vitro inhibition in sheep liver sorbitol dehydrogenase (s-SDH) ChEMBL. 11784155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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