Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 2 uM | Cytotoxic activity of compound against uninfected MRC5 cells | ChEMBL. | 8558524 |
CC50 (functional) | = 2 uM | Cytotoxic activity of compound against uninfected MRC5 cells | ChEMBL. | 8558524 |
CC50 (functional) | = 4 uM | Cytotoxic activity of compound against growing cultures of human leukemicB-cell line IM-9 | ChEMBL. | 8558524 |
CC50 (functional) | = 4 uM | Cytotoxic activity of compound against growing cultures of human leukemicB-cell line IM-9 | ChEMBL. | 8558524 |
CC50 (functional) | = 9 uM | Cytotoxic activity of compound against growing cultures of human leukemic T-cell lines CEM | ChEMBL. | 8558524 |
CC50 (functional) | = 9 uM | Cytotoxic activity of compound against growing cultures of human leukemic T-cell lines CEM | ChEMBL. | 8558524 |
CC50 (functional) | = 13 uM | Cytotoxic activity of compound against uninfected 2.2.15 cells | ChEMBL. | 8558524 |
CC50 (functional) | = 13 uM | Cytotoxic activity of compound against uninfected 2.2.15 cells | ChEMBL. | 8558524 |
CC50 (functional) | = 14 uM | Cytotoxic activity of compound against growing cultures of human leukemic T-cell lines Molt-4 | ChEMBL. | 8558524 |
CC50 (functional) | = 14 uM | Cytotoxic activity of compound against growing cultures of human leukemic T-cell lines Molt-4 | ChEMBL. | 8558524 |
IC50 (functional) | = 0.002 uM | Inhibitory activity of compound against hepatitis B virus (HBV) in growing cultures of 2.2.15 cells | ChEMBL. | 8558524 |
IC50 (functional) | = 0.002 uM | Inhibitory activity of compound against hepatitis B virus (HBV) in growing cultures of 2.2.15 cells | ChEMBL. | 8558524 |
IC50 (functional) | = 0.06 uM | Inhibitory activity of compound against human cytomegalovirus (HCMV) strain AD169 in monolayers of MRC5 cells | ChEMBL. | 8558524 |
IC50 (functional) | = 0.06 uM | Inhibitory activity of compound against human cytomegalovirus (HCMV) strain AD169 in monolayers of MRC5 cells | ChEMBL. | 8558524 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8558524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.