Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0342 | 0.6605 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Mycobacterium ulcerans | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0342 | 0.6605 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0393 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0342 | 0.6605 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0342 | 0.6605 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0342 | 0.6605 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0342 | 0.6605 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0342 | 0.6605 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0393 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0342 | 0.6605 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0342 | 0.6605 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0342 | 0.6605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.6605 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0342 | 0.6605 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0393 | 1 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0393 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0342 | 0.6605 | 0.5 |
Toxoplasma gondii | cathepsin CPC1 | 0.0393 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0342 | 0.6605 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0393 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0342 | 0.6605 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0342 | 0.6605 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0342 | 0.6605 | 1 |
Onchocerca volvulus | 0.0342 | 0.6605 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0342 | 0.6605 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0342 | 0.6605 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0342 | 0.6605 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Effective concentration against HIV-1 strain LAV in human peripheral blood mononuclear (PBM) cells. | ChEMBL. | 8496934 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against uninfected PHA-stimulated peripheral blood mononuclear (PBM) cells | ChEMBL. | 8496934 |
IC50 (ADMET) | > 100 uM | Cytotoxic effect against vero cells. | ChEMBL. | 8496934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.