Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0225 | 0.5 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0225 | 0.5 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0225 | 0.5 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0225 | 0.5 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.5 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Schistosoma mansoni | pol-related | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0225 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0225 | 0.5 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0225 | 0.5 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0225 | 0.5 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0225 | 0.5 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0225 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against candida albicans was determined; Active | ChEMBL. | 9871613 | |
Activity (functional) | 0 | Antifungal activity against candida albicans was determined; Active | ChEMBL. | 9871613 |
IC50 (binding) | > 295 uM | Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay | ChEMBL. | 18977148 |
IC90 (functional) | = 0.05 ug ml-1 | Cytotoxicity of the compound against a human colon cancer cell line (HCT-116 cells) was reported | ChEMBL. | 9871613 |
IC90 (functional) | = 0.05 ug ml-1 | Cytotoxicity of the compound against a human colon cancer cell line (HCT-116 cells) was reported | ChEMBL. | 9871613 |
IZ (functional) | = 20 mm | Antifungal activity against Candida albicans at 0.1 ug | ChEMBL. | 7769392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.