Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dopamine receptor | 0.0077 | 0.2652 | 0.4715 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.5625 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0107 | 0.5625 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | ORL1-like opioid receptor | 0.0077 | 0.2652 | 0.4715 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.5625 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.5625 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | G-protein coupled receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | G-protein coupled receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0077 | 0.2652 | 0.4715 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.5625 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | putative neuropeptide receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | G protein-coupled receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | GnHR receptor homolog | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Serotonin receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | sulfakinin receptor protein | 0.0077 | 0.2652 | 0.4715 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.015 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.5625 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.5625 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Dopamine receptor protein 1 | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Dopamine receptor protein 2 | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | neuropeptide F receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0077 | 0.2652 | 0.4715 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Onchocerca volvulus | 0.0107 | 0.5625 | 1 | |
Brugia malayi | RE15519p | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | follicle stimulating hormone receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | AKH receptor | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | Serotonin receptor | 0.0077 | 0.2652 | 0.4715 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.5625 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2652 | 0.4715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HDL cholesterol (functional) | = 94 mg 100ml-1 | Hypocholesterolemic activity in 6-week old male mormocholesterolemic chickens using experiment 3 | ChEMBL. | 8120870 |
IC50 (functional) | 0 uM | LDL oxidation assay as spectrophotometric determination of TBARS; Not determined | ChEMBL. | 8120870 |
Inhibition (binding) | % | In vitro suppression of HMG-CoA reductase (HMGR) in Hep G2 cells; Not determined | ChEMBL. | 8120870 |
Inhibition (binding) | 0 % | In vitro suppression of HMG-CoA reductase (HMGR) in Hep G2 cells; Not determined | ChEMBL. | 8120870 |
Inhibition (functional) | = 40 % | In vitro inhibition of cholesterol biosynthesis in Hep G2 cells | ChEMBL. | 8120870 |
Inhibition (functional) | = 40 % | In vitro inhibition of cholesterol biosynthesis in Hep G2 cells | ChEMBL. | 8120870 |
LDL cholesterol (functional) | = 57 mg 100ml-1 | Hypocholesterolemic activity in 6-week old male mormocholesterolemic chickens using experiment 3 | ChEMBL. | 8120870 |
Potential (functional) | 0 | Oxidation potential using cyclic voltametry; Not determined | ChEMBL. | 8120870 |
Ratio (functional) | = 0.62 | Ratio of HDL/total cholesterol value | ChEMBL. | 8120870 |
Total cholesterol (functional) | = 152 mg 100ml-1 | Hypocholesterolemic activity in 6-week old male mormocholesterolemic chickens using experiment 3 | ChEMBL. | 8120870 |
Triglycerides (functional) | = 76 mg 100ml-1 | Hypocholesterolemic activity in 6-week old male mormocholesterolemic chickens using experiment 3 | ChEMBL. | 8120870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.