Detailed information for compound 259711

Basic information

Technical information
  • TDR Targets ID: 259711
  • Name: (3S,5S,10S,13S)-10,13-dimethyl-17-pyridin-3-y l-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradeca hydro-1H-cyclopenta[a]phenanthren-3-ol
  • MW: 353.541 | Formula: C24H35NO
  • H donors: 1 H acceptors: 2 LogP: 6.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1CC[C@]2([C@H](C1)CCC1C2CC[C@]2(C1CCC2c1cccnc1)C)C
  • InChi: 1S/C24H35NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-4,13,15,17-22,26H,5-12,14H2,1-2H3/t17-,18-,19?,20?,21?,22?,23-,24+/m0/s1
  • InChiKey: KSNHBAFYACINHV-PHWUIRMMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,5S,10S,13S)-10,13-dimethyl-17-(3-pyridyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major telomerase reverse transcriptase, putative 0.0098 0.0848 0.7359
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.004 0.023 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0248 0.022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.1152 0.112
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0025 0.0063 0.0009
Loa Loa (eye worm) hypothetical protein 0.0155 0.1451 0.1428
Mycobacterium ulcerans hypothetical protein 0.0025 0.0062 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.053 0.0502
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0302 0.0268
Schistosoma mansoni carbonic anhydrase 0.0029 0.0108 0.008
Echinococcus granulosus nmda type glutamate receptor 0.0098 0.084 0.0814
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.04 0.0372
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0127 0.1152 0.112
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0102 0.0889 0.0862
Echinococcus multilocularis acetylcholinesterase 0.0958 1 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0098 0.0848 0.7359
Loa Loa (eye worm) runx1 0.0058 0.0414 0.0387
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0077 0.0048
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0069 0.0536 0.0509
Schistosoma mansoni lozenge 0.0058 0.0414 0.0387
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0102 0.0889 0.0862
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.053 0.0503
Echinococcus multilocularis expressed conserved protein 0.0096 0.0822 0.0796
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0108 0.0079
Schistosoma mansoni glutamate receptor NMDA 0.0145 0.1348 0.1324
Treponema pallidum NADH oxidase 0.0025 0.0063 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.0222 0.0194
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.2655 0.2635
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0888 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0889 0.0863
Brugia malayi Thioredoxin reductase 0.0071 0.0561 0.0527
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.004 0.023 0.0203
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Loa Loa (eye worm) hypothetical protein 0.0314 0.3141 0.3122
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0302 0.0275
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0719 0.0692
Loa Loa (eye worm) ACC-1 protein 0.0102 0.0889 0.0863
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0102 0.0889 0.0862
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0047
Schistosoma mansoni nAChR subunit 0.0047 0.0302 0.0275
Onchocerca volvulus 0.0162 0.1523 0.3153
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0327 0.0299
Brugia malayi jmjC domain containing protein 0.0026 0.0077 0.0042
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1451 0.1427
Onchocerca volvulus 0.004 0.023 0.0362
Loa Loa (eye worm) thioredoxin reductase 0.0071 0.0561 0.0534
Onchocerca volvulus 0.0162 0.1523 0.3153
Schistosoma mansoni glutamate receptor NMDA 0.0165 0.1555 0.1531
Onchocerca volvulus 0.0162 0.1523 0.3153
Echinococcus multilocularis carbonic anhydrase II 0.0127 0.1152 0.1126
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0888 0.0856
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0108 0.0073
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0025 0.0063 0.0009
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0386 0.0352
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0197 0.0169
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0958 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Entamoeba histolytica hypothetical protein 0.0037 0.0197 0.1678
Entamoeba histolytica hypothetical protein 0.0037 0.0197 0.1678
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0302 0.0268
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.053 0.431
Onchocerca volvulus 0.003 0.0117 0.012
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Echinococcus granulosus microtubule associated protein 2 0.0717 0.743 0.7423
Schistosoma mansoni hypothetical protein 0.0176 0.1673 0.165
Loa Loa (eye worm) carboxylesterase 0.0958 1 1
Onchocerca volvulus 0.0162 0.1523 0.3153
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.4322 0.4306
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0149
Mycobacterium ulcerans dehydrogenase 0.004 0.023 0.0293
Echinococcus granulosus acetylcholinesterase 0.0958 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0102 0.0889 0.0862
Trichomonas vaginalis spcc417.12 protein, putative 0.0162 0.1523 0.5632
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.023 0.0317
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0006
Schistosoma mansoni acetylcholinesterase 0.0162 0.1523 0.15
Brugia malayi CHE-14 protein 0.0044 0.0267 0.0232
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.053 0.0496
Brugia malayi Bromodomain containing protein 0.0033 0.0148 0.0113
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.04 0.0372
Onchocerca volvulus 0.0162 0.1523 0.3153
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.008
Brugia malayi hypothetical protein 0.0047 0.0302 0.0268
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0058 0.0505
Mycobacterium ulcerans carboxylesterase, LipT 0.0162 0.1523 0.2504
Onchocerca volvulus 0.0102 0.0889 0.1784
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0067 0.0039
Plasmodium vivax SET domain protein, putative 0.0032 0.0137 0.0994
Onchocerca volvulus 0.0047 0.0302 0.0518
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.053 0.0503
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0176 0.0142
Schistosoma mansoni gliotactin 0.0162 0.1523 0.15
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Onchocerca volvulus 0.0047 0.0302 0.0518
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0025 0.0063 0.0028
Echinococcus multilocularis nmda type glutamate receptor 0.0098 0.084 0.0814
Brugia malayi Glutamate receptor 1 precursor 0.0058 0.0419 0.0385
Echinococcus multilocularis para nitrobenzyl esterase 0.0162 0.1523 0.1499
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0102 0.0889 0.0862
Brugia malayi Bromodomain containing protein 0.008 0.0647 0.0614
Echinococcus granulosus BC026374 protein S09 family 0.0162 0.1523 0.1499
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0325 0.0298
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2108 0.2086
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Brugia malayi Carboxylesterase family protein 0.0162 0.1523 0.1493
Echinococcus multilocularis thioredoxin glutathione reductase 0.0071 0.0561 0.0533
Loa Loa (eye worm) hypothetical protein 0.0042 0.025 0.0223
Brugia malayi jmjC domain containing protein 0.0026 0.0077 0.0042
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0713 0.7887
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0122 0.0094
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0127 0.1152 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0025 0.0063 0.0065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.04 0.0366
Brugia malayi mbt repeat family protein 0.005 0.0327 0.0293
Loa Loa (eye worm) hypothetical protein 0.0056 0.04 0.0373
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0302 0.0275
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0102 0.0889 0.0857
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0074 0.0046
Brugia malayi excitatory GABA receptor EXP-1A 0.0102 0.0889 0.0857
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.023 0.0202
Echinococcus granulosus glutamate receptor NMDA 0.0076 0.0611 0.0584
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1774 0.6601
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0127 0.1152 0.1127
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0027
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.036 0.3636 0.7711
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0889 0.0857
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0077 0.0048
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0302 0.0274
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0118 0.0089
Brugia malayi hypothetical protein 0.0162 0.1523 0.1493
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0108 0.008
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0102 0.0889 0.0863
Entamoeba histolytica hypothetical protein 0.0055 0.0386 0.3954
Mycobacterium tuberculosis Carboxylesterase LipT 0.0162 0.1523 0.2703
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0077 0.0049
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0067 0.0038
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.0889 0.0862
Echinococcus multilocularis glutamate receptor 2 0.0069 0.0536 0.0509
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1673 0.3476
Onchocerca volvulus 0.0102 0.0889 0.1784
Plasmodium falciparum glutathione reductase 0.0025 0.0063 0.0065
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0063 0.0009
Loa Loa (eye worm) glutathione reductase 0.0071 0.0561 0.0534
Echinococcus granulosus carboxylesterase 5A 0.0958 1 1
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0248 0.022
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0102 0.0889 0.0857
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0302 0.0275
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0162 0.1523 0.15
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.004 0.023 0.2174
Plasmodium falciparum thioredoxin reductase 0.0071 0.0561 0.6365
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0325 0.0297
Schistosoma mansoni hypothetical protein 0.0037 0.0197 0.017
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0537
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0062 0.0043
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Loa Loa (eye worm) carboxylesterase 0.0162 0.1523 0.15
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.743 0.7423
Brugia malayi Glutamate receptor 2 precursor 0.0058 0.0419 0.0385
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Schistosoma mansoni hypothetical protein 0.0035 0.0176 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Brugia malayi Telomerase reverse transcriptase 0.0262 0.2588 0.2562
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0102 0.0889 0.0863
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0102 0.0889 0.0857
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0077 0.0049
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0419 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0386 0.0352
Echinococcus multilocularis cpg binding protein 0.0034 0.0156 0.0128
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0327 0.03
Echinococcus granulosus carbonic anhydrase II 0.0127 0.1152 0.1126
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0077 0.0173
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0302 0.0275
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0386 0.036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0351 0.0324
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.004 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0526 0.0499
Brugia malayi Carboxylesterase family protein 0.0162 0.1523 0.1493
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0122 0.0094
Echinococcus granulosus neuroligin 0.0162 0.1523 0.1499
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0386 0.0352
Onchocerca volvulus 0.0032 0.0137 0.0162
Echinococcus multilocularis 0.004 0.023 0.0202
Giardia lamblia Telomerase catalytic subunit 0.0098 0.0848 1
Brugia malayi hypothetical protein 0.0047 0.0302 0.0268
Schistosoma mansoni hypothetical protein 0.0029 0.0108 0.008
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0165 0.1555 0.153
Plasmodium vivax JmjC domain containing protein 0.0026 0.0077 0.024
Brugia malayi Cation transporter family protein 0.0102 0.0889 0.0857
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0025 0.0063 0.0065
Brugia malayi PHD-finger family protein 0.003 0.0122 0.0087
Schistosoma mansoni jumonji domain containing protein 0.014 0.1289 0.1264
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0102 0.0889 0.0863
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0102 0.0889 0.0862
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0025 0.0063 0.0065
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.0889 0.0863
Plasmodium falciparum protoporphyrinogen oxidase 0.004 0.023 0.2174
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0533 0.5478 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.008
Echinococcus multilocularis carboxylesterase 5A 0.0958 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.025 0.0223
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.0386 0.036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.1506 0.1481
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0289 0.0262
Echinococcus multilocularis peregrin 0.0033 0.0148 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.0025 0.0063 0.055
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0162 0.1523 0.5632
Onchocerca volvulus 0.0102 0.0889 0.1784
Toxoplasma gondii RNA-directed DNA polymerase 0.0098 0.0848 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0025 0.0063 0.03
Onchocerca volvulus 0.0247 0.2426 0.51
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0077 0.0048
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0047 0.0302 0.0274
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0574 0.5908 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.044 0.4832
Echinococcus granulosus nAChR subunit 0.0055 0.0386 0.0359
Echinococcus multilocularis BC026374 protein (S09 family) 0.0162 0.1523 0.1499
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Toxoplasma gondii NADPH-glutathione reductase 0.0025 0.0063 0.0065
Echinococcus multilocularis nmda type glutamate receptor 0.0087 0.0728 0.0702
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0008
Plasmodium vivax telomerase reverse transcriptase, putative 0.0098 0.0848 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.04 0.0372
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0122 0.0093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0077 0.067
Onchocerca volvulus 0.005 0.0327 0.0572
Loa Loa (eye worm) hypothetical protein 0.0086 0.0713 0.0687
Loa Loa (eye worm) hypothetical protein 0.0073 0.0582 0.0555
Brugia malayi PHD-finger family protein 0.0028 0.0093 0.0058
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1355 0.133
Echinococcus multilocularis neuroligin 0.0162 0.1523 0.1499
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0267 0.024
Schistosoma mansoni zinc finger protein 0.0022 0.0034 0.0006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0069 0.0536 0.0509
Brugia malayi Cation transporter family protein 0.0102 0.0889 0.0857
Brugia malayi jmjC domain containing protein 0.016 0.1506 0.1476
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0077 0.0048
Leishmania major carbonic anhydrase-like protein 0.0127 0.1152 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0537
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0102 0.0889 0.0857
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0077 0.0049
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0025 0.0063 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0137 0.0109
Brugia malayi Carboxylesterase family protein 0.0162 0.1523 0.1493
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.053 0.5679
Mycobacterium ulcerans monoamine oxidase 0.004 0.023 0.0293
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0127 0.1152 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0117 0.009
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0047 0.0302 0.0275
Loa Loa (eye worm) hypothetical protein 0.0958 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0108 0.0073
Schistosoma mansoni neuroligin 3 (S09 family) 0.0162 0.1523 0.15
Echinococcus multilocularis protein dispatched 1 0.005 0.0333 0.0305
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0077 0.0049
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0047 0.0302 0.0274
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.053 0.4598
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0036
Schistosoma mansoni hypothetical protein 0.0042 0.025 0.0223
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0069 0.0536 0.0509
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0067 0.0038
Echinococcus multilocularis protoporphyrinogen oxidase 0.004 0.023 0.0202
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Schistosoma mansoni cpg binding protein 0.003 0.0117 0.009
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0302 0.0268
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0036 0.0311
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0889 0.0857
Schistosoma mansoni ATP-binding cassette transporter 0.0058 0.0419 0.0392
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0077 0.024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.008
Onchocerca volvulus 0.0047 0.0302 0.0518
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0074 0.0046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0116 0.0088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0372 0.0345
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0162 0.1523 0.15
Brugia malayi hypothetical protein 0.0047 0.0302 0.0268
Echinococcus granulosus glutamate receptor 2 0.0069 0.0536 0.0509
Onchocerca volvulus Alhambra homolog 0.003 0.0122 0.013
Onchocerca volvulus 0.046 0.4697 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0127 0.1152 0.1127
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Echinococcus granulosus acetylcholinesterase 0.0958 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0162 0.1523 0.15
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Brugia malayi hypothetical protein 0.004 0.023 0.0195
Plasmodium vivax hypothetical protein, conserved 0.003 0.0122 0.0808
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0063 1
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0327 0.03
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.023 0.1995
Loa Loa (eye worm) hypothetical protein 0.003 0.0122 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0267 0.0785
Schistosoma mansoni patched 1 0.0044 0.0267 0.024
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0574 0.5908 1
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0327 0.0299
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0025 0.0063 0.0065
Loa Loa (eye worm) carboxylesterase 0.0162 0.1523 0.15
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1774 0.6601
Echinococcus granulosus glutamate receptor 2 0.0048 0.0307 0.0279
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0077 0.067
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0069 0.0536 0.0509
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0077 0.0049
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0108 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0197 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0062 0.0007
Echinococcus granulosus zinc finger protein 0.0022 0.0034 0.0005
Loa Loa (eye worm) hypothetical protein 0.046 0.4697 0.4682
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0077 0.024
Brugia malayi Bromodomain containing protein 0.004 0.0223 0.0189
Plasmodium vivax hypothetical protein, conserved 0.004 0.023 0.2174
Brugia malayi hypothetical protein 0.0047 0.0302 0.0268
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Loa Loa (eye worm) hypothetical protein 0.0049 0.0325 0.0298
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0074 0.0204
Loa Loa (eye worm) hypothetical protein 0.0086 0.0719 0.0693
Plasmodium falciparum thioredoxin reductase 0.0025 0.0063 0.0065
Loa Loa (eye worm) hypothetical protein 0.046 0.4697 0.4682
Echinococcus multilocularis lysine specific histone demethylase 1A 0.004 0.023 0.0202
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Brugia malayi Muscleblind-like protein 0.0155 0.1451 0.1421
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0222 0.0194
Entamoeba histolytica hypothetical protein 0.0037 0.0197 0.1678
Echinococcus granulosus peregrin 0.0033 0.0148 0.012
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.0419 0.0392
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0102 0.0889 0.0863
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.023 0.1995
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0137 0.0108
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0108 0.0079
Echinococcus multilocularis zinc finger protein 0.0022 0.0034 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0069 0.0536 0.0509
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0162 0.1523 0.2703
Mycobacterium ulcerans oxidoreductase 0.004 0.023 0.0293
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0713 0.7887
Schistosoma mansoni hypothetical protein 0.003 0.0122 0.0094
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0478 0.045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.023 0.2174
Echinococcus granulosus thioredoxin glutathione reductase 0.0071 0.0561 0.0533
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.0889 0.0862
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0049
Trypanosoma brucei carbonic anhydrase-like protein 0.0127 0.1152 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0386 0.036
Onchocerca volvulus 0.0314 0.3141 0.6643
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0478 0.045
Echinococcus granulosus muscleblind protein 0.0155 0.1451 0.1427
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0098 0.0848 0.7359
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0127 0.1152 0.1127
Plasmodium falciparum glutathione reductase 0.0071 0.0561 0.6365
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.023 0.0317
Leishmania major UDP-galactopyranose mutase 0.004 0.023 0.1995
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0102 0.0889 0.0862
Brugia malayi Carboxylesterase family protein 0.0162 0.1523 0.1493
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0102 0.0889 0.0863
Brugia malayi mbt repeat family protein 0.005 0.0327 0.0293
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.0889 0.0862
Loa Loa (eye worm) LGC-31 protein 0.0102 0.0889 0.0863
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0102 0.0889 0.0862
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0302 0.0274
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0419 0.0392
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0419 0.0391
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0077 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0102 0.0889 0.0863
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0102 0.0889 0.0862
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0302 0.0274
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0102 0.0889 0.0857
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0267 0.0239
Brugia malayi hypothetical protein 0.0314 0.3141 0.3117
Echinococcus granulosus phd:f box containing protein 0.0026 0.0077 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0102 0.0889 0.0862
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Echinococcus multilocularis glutamate receptor NMDA 0.0076 0.0611 0.0584
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.04 0.0372
Loa Loa (eye worm) hypothetical protein 0.0155 0.1451 0.1428
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0162 0.1523 0.1499
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.053 0.4598
Schistosoma mansoni hypothetical protein 0.0042 0.025 0.0223
Loa Loa (eye worm) hypothetical protein 0.004 0.0224 0.0197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0062 0.0043
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0719 0.0692
Schistosoma mansoni nAChR subunit 0.0047 0.0302 0.0275
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0025 0.0063 0.055
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0888 0.0862
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.023 0.0202
Schistosoma mansoni Lysine-specific histone demethylase 1 0.004 0.023 0.0203
Brugia malayi SWIRM domain containing protein 0.004 0.023 0.0195
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Echinococcus granulosus cpg binding protein 0.0034 0.0156 0.0128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0889 0.0863
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0386 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0062 0.0006
Schistosoma mansoni cpg binding protein 0.0034 0.0156 0.0129
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Brugia malayi hypothetical protein 0.0047 0.0302 0.0268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0197 0.0169
Loa Loa (eye worm) hypothetical protein 0.0044 0.0267 0.024
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0719 0.0686
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0325 0.0297
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2426 0.9115
Echinococcus granulosus nmda type glutamate receptor 0.0087 0.0728 0.0702
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0102 0.0889 0.0862
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0027
Giardia lamblia PHD finger protein 15 0.003 0.0122 0.0748
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0307 0.0279
Loa Loa (eye worm) hypothetical protein 0.0958 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0077 0.0049
Brugia malayi Pre-SET motif family protein 0.0032 0.0137 0.0102
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0063 0.055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0062 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0122 0.0808
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Schistosoma mansoni hypothetical protein 0.0301 0.3006 0.2986
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0069 0.0536 0.0509
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0077 0.0049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0327 0.0572
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Echinococcus multilocularis nAChR subunit 0.0055 0.0386 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0074 0.0042
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0116 0.0088
Plasmodium falciparum phd finger protein, putative 0.003 0.0122 0.0808
Onchocerca volvulus 0.0102 0.0889 0.1784
Leishmania major trypanothione reductase 0.0071 0.0561 0.4868
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0351 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Echinococcus granulosus glutamate NMDA receptor subunit 0.0165 0.1555 0.153
Echinococcus multilocularis acetylcholinesterase 0.0958 1 1
Echinococcus granulosus expressed conserved protein 0.0096 0.0822 0.0796
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0197 0.0169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0302 0.0268
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Entamoeba histolytica hypothetical protein 0.0037 0.0197 0.1678
Schistosoma mansoni hypothetical protein 0.0176 0.1673 0.165
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0077 0.0048
Schistosoma mansoni amine oxidase 0.004 0.023 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0137 0.0994
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0108 0.0073
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0302 0.0275
Brugia malayi hypothetical protein 0.046 0.4697 0.4678
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.023 0.0195
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0888 0.0862
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0077 0.0048
Echinococcus granulosus carbonic anhydrase 0.0029 0.0108 0.0079
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0122 0.0808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0325 0.0298
Plasmodium falciparum telomerase reverse transcriptase 0.0098 0.0848 1
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0025 0.0063 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0025 0.0063 0.0065
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0025 0.0063 0.03
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Trypanosoma brucei trypanothione reductase 0.0071 0.0561 0.4594
Toxoplasma gondii hypothetical protein 0.0029 0.0108 0.0629
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0025 0.0063 0.0047
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.0889 0.0863
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.0419 0.0392
Brugia malayi jmjC domain containing protein 0.0026 0.0077 0.0042
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0074 0.0147
Loa Loa (eye worm) carbonic anhydrase 3 0.0127 0.1152 0.1127
Loa Loa (eye worm) jmjC domain-containing protein 0.0101 0.0879 0.0854
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0063 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Echinococcus granulosus lysine specific demethylase 5A 0.0101 0.0879 0.0853
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1355 0.133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Loa Loa (eye worm) GABA receptor subunit 0.0055 0.0386 0.036
Loa Loa (eye worm) glutamate receptor 1 0.0058 0.0419 0.0392
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0069 0.0536 0.0509
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0006
Echinococcus granulosus para nitrobenzyl esterase 0.0162 0.1523 0.1499
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.0879 0.0854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0034
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.0249 0.2419
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.005 0.0327 0.03
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi jmjC domain containing protein 0.0101 0.0879 0.0847
Loa Loa (eye worm) glutamate receptor 2 0.0058 0.0419 0.0392
Brugia malayi jmjC domain containing protein 0.0026 0.0077 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0063 0.055
Brugia malayi glutathione reductase 0.0071 0.0561 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0905 0.088
Brugia malayi hypothetical protein 0.0037 0.0197 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0137 0.0109
Loa Loa (eye worm) acetylcholinesterase 1 0.0958 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0102 0.0889 0.0863
Brugia malayi Pre-SET motif family protein 0.0217 0.2108 0.208
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0062 0.0007
Echinococcus multilocularis nAChR subunit 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0485 0.0459
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0108 0.008
Echinococcus multilocularis geminin 0.0176 0.1673 0.1649
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0327 0.03
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0062 0.0209
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.053 0.4598
Leishmania major hypothetical protein, conserved 0.0026 0.0077 0.067
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0108 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0537
Plasmodium vivax thioredoxin reductase, putative 0.0071 0.0561 0.6365
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0074 0.0645
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.053 0.0502
Echinococcus granulosus carbonic anhydrase 0.0029 0.0108 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0063 0.055
Onchocerca volvulus 0.0102 0.0889 0.1784
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0108 0.0073
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0102 0.0889 0.0857
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0077 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0351 0.0317
Schistosoma mansoni hypothetical protein 0.0425 0.4322 0.4306
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.0889 0.0862
Schistosoma mansoni hypothetical protein 0.0042 0.025 0.0223
Loa Loa (eye worm) hypothetical protein 0.0052 0.0351 0.0324
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0108 0.008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.1506 0.1481
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0062 0.0006
Echinococcus granulosus nAChR subunit 0.0102 0.0889 0.0862
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2655 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0025 0.0063 0.0009
Onchocerca volvulus 0.0055 0.0386 0.07
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0561 0.4868
Loa Loa (eye worm) ACC-1 protein 0.0102 0.0889 0.0863
Plasmodium vivax hypothetical protein, conserved 0.004 0.023 0.2174
Onchocerca volvulus 0.0086 0.0719 0.1418
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0267 0.0239
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0327 0.0299
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0025 0.0063 0.0009
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0074 0.0047
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0302 0.0268
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.04 0.0373
Loa Loa (eye worm) hypothetical protein 0.0162 0.1523 0.15
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0025 0.0063 0.055
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0889 0.0863
Loa Loa (eye worm) hypothetical protein 0.004 0.023 0.0203
Brugia malayi CXXC zinc finger family protein 0.003 0.0117 0.0082
Plasmodium falciparum carbonic anhydrase 0.0029 0.0108 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1673 0.6211
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0267 0.0239
Echinococcus multilocularis protein patched 0.0044 0.0267 0.0239
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0071 0.0561 0.0927
Plasmodium vivax glutathione reductase, putative 0.0071 0.0561 0.6365
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0025 0.0063 0.0009
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.1878 0.1855
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.1878 0.1855
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0889 0.0857
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0327 0.0299
Schistosoma mansoni BC026374 protein (S09 family) 0.0162 0.1523 0.15
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0162 0.1523 0.2703
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0102 0.0889 0.0857
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.084 0.0814
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0419 0.0392
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0302 0.0275
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.0889 0.0862
Onchocerca volvulus Putative nachr subunit 0.0102 0.0889 0.1784
Onchocerca volvulus 0.0102 0.0889 0.1784
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0162 0.1523 0.1499
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0062 0.0209
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0108 0.0079
Brugia malayi Carboxylesterase family protein 0.0958 1 1
Onchocerca volvulus 0.0055 0.0386 0.07
Echinococcus multilocularis Protein lozenge 0.0058 0.0414 0.0386
Plasmodium vivax protoporphyrinogen oxidase, putative 0.004 0.023 0.2174
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0122 0.0093
Toxoplasma gondii thioredoxin reductase 0.0071 0.0561 0.6365
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0719 0.0693
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0889 0.0857
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.036
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0302 0.0268
Echinococcus granulosus dnaJ subfamily B 0.0425 0.4322 0.4306
Schistosoma mansoni cpg binding protein 0.0034 0.0156 0.0129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.0879 0.0854
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0062 0.0006
Loa Loa (eye worm) MBCTL1 0.0056 0.04 0.0373
Toxoplasma gondii histone lysine-specific demethylase 0.004 0.023 0.2174
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.2655 0.2629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0074 0.0039
Schistosoma mansoni bromodomain containing protein 0.0067 0.0517 0.0491
Echinococcus multilocularis muscleblind protein 0.0155 0.1451 0.1427
Mycobacterium ulcerans protoporphyrinogen oxidase 0.004 0.023 0.0293
Schistosoma mansoni amine oxidase 0.004 0.023 0.0203
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0062 0.0043
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0069 0.0536 0.0509
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0077 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.743 0.7423
Schistosoma mansoni nAChR subunit 0.0102 0.0889 0.0863
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275
Brugia malayi Cation transporter family protein 0.0102 0.0889 0.0857
Echinococcus granulosus geminin 0.0176 0.1673 0.1649
Entamoeba histolytica hypothetical protein 0.0026 0.0074 0.0194
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0327 0.03
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.004 0.023 0.2174
Trypanosoma brucei telomerase reverse transcriptase 0.0098 0.0848 0.7219
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0465 0.0439
Loa Loa (eye worm) hypothetical protein 0.0102 0.0888 0.0863
Echinococcus granulosus carbonic anhydrase 0.0029 0.0108 0.0079
Loa Loa (eye worm) hypothetical protein 0.0102 0.0889 0.0863
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0197 0.017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0889 0.0862
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0275

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 nM Inhibition of human progesterone 17-alpha-hydroxylase. ChEMBL. 9876107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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