Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 0.0084 | 0.0966 | 0.0997 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.0641 | 0.0635 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0328 | 0.0377 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Plasmodium vivax | hypothetical protein, conserved | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0413 | 0.0457 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0966 | 0.1068 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0189 | 0.3069 | 0.334 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0413 | 0.0457 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0072 | 0.0079 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0068 | 0.0641 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | set domain proteins, putative | 0.0536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0084 | 0.0966 | 0.1068 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0328 | 0.0377 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0084 | 0.0966 | 0.0577 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0068 | 0.0641 | 0.0635 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Toxoplasma gondii | flagellar/basal body protein | 0.0084 | 0.0966 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.0641 | 0.0737 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0068 | 0.0641 | 0.0635 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.0641 | 0.6368 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | Cytosolic carboxypeptidase 1 homolog | 0.0084 | 0.0966 | 0.0577 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0413 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0189 | 0.3069 | 0.3393 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.4584 | 0.5269 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0328 | 0.0377 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0488 | 0.9045 | 1 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0488 | 0.9045 | 0.9004 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.0737 |
Onchocerca volvulus | 0.0068 | 0.0641 | 0.0238 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Pre-SET motif family protein | 0.0471 | 0.87 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0084 | 0.0966 | 0.111 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.4584 | 0.5269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0328 | 0.0377 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0672 | 0.0772 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.4584 | 0.5269 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | hypothetical protein | 0.0189 | 0.3069 | 0.3527 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0592 | 0.0579 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3069 | 0.3393 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0471 | 0.87 | 1 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.737 | 0.8472 |
Echinococcus granulosus | geminin | 0.0376 | 0.6804 | 0.7503 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0189 | 0.3069 | 0.334 |
Onchocerca volvulus | 0.0102 | 0.1325 | 0.0951 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Echinococcus multilocularis | geminin | 0.0376 | 0.6804 | 0.7503 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Appearence of mouse peritoneal macrophages after 3h of treatment with compound at a concentration of 0.375 mM; OK | ChEMBL. | 7045368 |
Activity (functional) | = 21 % | Induction of cell death in mouse P815 cells assessed as [51Cr] release at 100 ug/ml at 5 hrs (Rvb = 10%) | ChEMBL. | 114658 |
Cr release (functional) | = 15 % | Toxicity toward P-815 Mastocytoma cells after 5 hr was determined as percent of [51Cr]- release from labeled cells as a measure of cell death. at a concentration of 0.750 mM. (expt III) | ChEMBL. | 7045368 |
Cr release (functional) | = 15 % | Toxicity toward P-815 Mastocytoma cells after 5 hr was determined as percent of [51Cr]- release from labeled cells as a measure of cell death. at a concentration of 0.750 mM. (expt III) | ChEMBL. | 7045368 |
LDH release (functional) | = 52 % | Cytotoxicity was determined against mouse peritoneal macrophages(MPM) and the percent of LDH released after 24 hr was determined as a measure of cell death at a concentration of 0.375 mM (expt I) | ChEMBL. | 7045368 |
LDH release (functional) | = 52 % | Cytotoxicity was determined against mouse peritoneal macrophages(MPM) and the percent of LDH released after 24 hr was determined as a measure of cell death at a concentration of 0.375 mM (expt I) | ChEMBL. | 7045368 |
LDH release (functional) | = 64 % | Cytotoxicity was determined against mouse peritoneal macrophages(MPM) and the percent of LDH released after 24 hr was determined as a measure of cell death at a concentration of 0.375 mM (expt II) | ChEMBL. | 7045368 |
LDH release (functional) | = 64 % | Cytotoxicity was determined against mouse peritoneal macrophages(MPM) and the percent of LDH released after 24 hr was determined as a measure of cell death at a concentration of 0.375 mM (expt II) | ChEMBL. | 7045368 |
Toxicity (functional) | = 100 ug ml-1 | Cytotoxicity was determined for the compound against mouse peritoneal macrophages(MPM) at a concentration of 0.375 mM. | ChEMBL. | 7045368 |
Toxicity (functional) | = 100 ug ml-1 | Cytotoxicity was determined for the compound against mouse peritoneal macrophages(MPM) at a concentration of 0.375 mM. | ChEMBL. | 7045368 |
Toxicity (functional) | = 200 ug ml-1 | Toxicity was evaluated for the compound at a concentration of 0.750 mM against P-185 Mastocytoma. | ChEMBL. | 7045368 |
Toxicity (functional) | = 200 ug ml-1 | Toxicity was evaluated for the compound at a concentration of 0.750 mM against P-185 Mastocytoma. | ChEMBL. | 7045368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.