Detailed information for compound 259774

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 689.327 | Formula: C14H26N5Na4O13P3S
  • H donors: 4 H acceptors: 12 LogP: -3.89 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCCSc1nc2c(n1C1OC(C(C1O)O)COP(=O)(OP(=O)(OP([O-])([O-])[O-])[O-])O)ncnc2N.[NaH+].[NaH+].[NaH+].[NaH+]
  • InChi: 1S/C14H23N5O13P3S.4Na/c1-2-3-4-36-14-18-8-11(15)16-6-17-12(8)19(14)13-10(21)9(20)7(30-13)5-29-34(25,26)32-35(27,28)31-33(22,23)24;;;;/h6-7,9-10,13,20-21,33H,2-5H2,1H3,(H,25,26)(H,27,28)(H2,15,16,17);;;;/q-3;4*+1/p-1
  • InChiKey: GNCVCYVLSUNUQV-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L-like precursor 0.0011 0.0117 0.0129
Echinococcus multilocularis cysteine protease 0.0017 0.0254 0.0212
Toxoplasma gondii flavodoxin domain-containing protein 0.0078 0.1778 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0156 0.3747 0.372
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0156 0.3747 1
Plasmodium vivax vivapain-2 0.0017 0.0254 0.0546
Echinococcus multilocularis cysteine protease 0.0017 0.0254 0.0212
Trypanosoma brucei NADH-dependent fumarate reductase 0.0018 0.0283 0.0623
Brugia malayi Doublecortin family protein 0.002 0.0328 0.0554
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0254 0.0245
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0096 0.2252 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0254 0.0443
Loa Loa (eye worm) hypothetical protein 0.0156 0.3747 0.7412
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0552
Leishmania major cathepsin L-like protease 0.0063 0.1423 0.3347
Loa Loa (eye worm) hypothetical protein 0.002 0.0328 0.049
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0018 0.0283 0.5
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0254 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1423 0.371
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0328 0.0287
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0117 0.0129
Leishmania major oxidoreductase-like protein 0.0018 0.0283 0.0081
Onchocerca volvulus 0.0017 0.0254 0.0245
Leishmania major reductase, putative 0.0018 0.0283 0.0081
Onchocerca volvulus 0.0017 0.0254 0.0245
Giardia lamblia Nitric oxide synthase, inducible 0.0138 0.3302 1
Leishmania major cathepsin L-like protease 0.0063 0.1423 0.3347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Brugia malayi Pre-SET motif family protein 0.0207 0.5024 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0254 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus multilocularis cytochrome b5 reductase 4 0.0018 0.0283 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus granulosus cysteine protease 0.0009 0.0053 0.001
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0138 0.3302 0.5754
Plasmodium vivax vivapain-2 0.0017 0.0254 0.0546
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0117 0.0074
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Schistosoma mansoni polycystin 1-related 0.002 0.0328 0.0287
Leishmania major NADH-dependent fumarate reductase-like protein 0.0018 0.0283 0.0081
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.006 0.1333 0.3467
Onchocerca volvulus 0.003 0.0596 0.0852
Leishmania major cathepsin L-like protease 0.0063 0.1423 0.3347
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.5024 1
Echinococcus multilocularis dnaJ subfamily B 0.0406 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0328 0.0287
Schistosoma mansoni cytochrome B5 0.0018 0.0283 0.0241
Onchocerca volvulus 0.0018 0.0283 0.0295
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0156 0.3747 0.372
Loa Loa (eye worm) FAD binding domain-containing protein 0.0096 0.2252 0.4385
Leishmania major hypothetical protein, conserved 0.006 0.1333 0.309
Leishmania major NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0081
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0254 0.0245
Leishmania major NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0081
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0254 0.034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1217 0.6322
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0156 0.3747 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1286 0.3338
Trypanosoma brucei oxidoreductase-protein, putative 0.0018 0.0283 0.0623
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0596 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0053 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0328 0.0287
Loa Loa (eye worm) hypothetical protein 0.003 0.0596 0.1031
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0328 0.0287
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0156 0.3747 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0156 0.3747 1
Onchocerca volvulus 0.0236 0.5739 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0018 0.0283 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0254 0.1575
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0328 0.0287
Onchocerca volvulus 0.0017 0.0254 0.0245
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Mycobacterium tuberculosis Probable oxidoreductase 0.0018 0.0283 0.5
Treponema pallidum flavodoxin 0.006 0.1333 1
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Loa Loa (eye worm) flavodoxin family protein 0.006 0.1333 0.2525
Onchocerca volvulus 0.002 0.0328 0.0376
Plasmodium falciparum ferredoxin--NADP reductase 0.0018 0.0283 0.0623
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0084 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0117 0.0501
Leishmania major NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0053 0.0092
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0254 0.0546
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0254 0.0546
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.0943
Mycobacterium tuberculosis Probable monooxygenase 0.0018 0.0283 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0254 0.0212
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0254 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.121 0.1172
Schistosoma mansoni lipoxygenase 0.0055 0.121 0.1172
Schistosoma mansoni loxhd1 0.002 0.0328 0.0287
Onchocerca volvulus 0.0029 0.0552 0.0774
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0053 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0596 0.0555
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0156 0.3747 1
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0156 0.3747 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0117 0.0129
Onchocerca volvulus 0.0017 0.0254 0.0245
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0328 0.0287
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Chlamydia trachomatis sulfite reductase 0.0096 0.2252 1
Echinococcus granulosus RUN 0.002 0.0328 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Leishmania major NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0081
Plasmodium falciparum nitric oxide synthase, putative 0.0156 0.3747 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0078 0.1778 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.006 0.1333 0.3467
Plasmodium vivax hypothetical protein, conserved 0.006 0.1333 0.3467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0254 0.034
Trichomonas vaginalis NADPH cytochrome P450, putative 0.006 0.1333 0.2323
Schistosoma mansoni lipoxygenase 0.002 0.0328 0.0287
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0552
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0254 0.0406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Loa Loa (eye worm) ctsf protein 0.0017 0.0254 0.034
Plasmodium vivax SET domain protein, putative 0.003 0.0596 0.147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Echinococcus multilocularis methionine synthase reductase 0.0096 0.2252 0.2218
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0328 0.0746
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0254 0.0212
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0018 0.0283 0.0623
Mycobacterium tuberculosis Possible oxygenase 0.0018 0.0283 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0596 0.0555
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0254 0.1575
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0156 0.3747 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0254 0.0212
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Loa Loa (eye worm) hypothetical protein 0.002 0.0328 0.049
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.006 0.1333 0.3467
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0053 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus granulosus cytochrome b5 reductase 4 0.0018 0.0283 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0254 0.034
Trichomonas vaginalis NADPH cytochrome P450, putative 0.006 0.1333 0.2323
Loa Loa (eye worm) cysteine protease 0.0017 0.0254 0.034
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0596 0.0555
Entamoeba histolytica type A flavoprotein, putative 0.006 0.1333 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus multilocularis cathepsin L 0.0009 0.0053 0.001
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0117 0.0204
Trypanosoma brucei NADH-dependent fumarate reductase 0.0018 0.0283 0.0623
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0018 0.0283 0.0623
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Brugia malayi Cathepsin L-like precursor 0.0011 0.0117 0.0129
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0018 0.0283 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.1004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0596 0.0555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Trichomonas vaginalis NADPH cytochrome P450, putative 0.006 0.1333 0.2323
Leishmania major cytochrome P450 reductase, putative 0.0138 0.3302 0.8728
Trypanosoma cruzi oxidoreductase-protein, putative 0.0018 0.0283 0.0623
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0156 0.3747 1
Entamoeba histolytica type A flavoprotein, putative 0.006 0.1333 1
Trichomonas vaginalis set domain proteins, putative 0.0236 0.5739 1
Schistosoma mansoni diflavin oxidoreductase 0.0078 0.1778 0.1742
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0018 0.0283 0.0186
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.1084 0.2792
Echinococcus granulosus cytochrome b5 reductase 4 0.0018 0.0283 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Entamoeba histolytica type A flavoprotein, putative 0.006 0.1333 1
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0552
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Echinococcus granulosus cathepsin l1 0.0017 0.0254 0.0212
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Trypanosoma cruzi reductase, putative 0.0018 0.0283 0.0623
Onchocerca volvulus 0.0017 0.0254 0.0245
Echinococcus multilocularis RUN 0.002 0.0328 0.0287
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0156 0.3747 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0018 0.0283 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0254 0.0443
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Leishmania major nitrate reductase, putative 0.0018 0.0283 0.0081
Echinococcus granulosus cathepsin l1 0.0011 0.0117 0.0074
Entamoeba histolytica type A flavoprotein, putative 0.006 0.1333 1
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0018 0.0283 0.0463
Onchocerca volvulus 0.0017 0.0254 0.0245
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0018 0.0283 0.0241
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0062
Entamoeba histolytica type A flavoprotein, putative 0.006 0.1333 1
Schistosoma mansoni cytochrome P450 reductase 0.0156 0.3747 0.372
Loa Loa (eye worm) FAD binding domain-containing protein 0.0156 0.3747 0.7412
Trichomonas vaginalis sulfite reductase, putative 0.0156 0.3747 0.6529
Brugia malayi hypothetical protein 0.002 0.0328 0.0554
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0596 0.0555
Loa Loa (eye worm) diaphorase 0.0018 0.0283 0.0397
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0553 0.0512
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.006 0.1333 0.3467
Schistosoma mansoni NADPH flavin oxidoreductase 0.0079 0.1807 0.1772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Brugia malayi flavodoxin family protein 0.0156 0.3747 0.743
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1423 0.371
Leishmania major cytochrome-b5 reductase, putative 0.0018 0.0283 0.0081
Schistosoma mansoni hypothetical protein 0.002 0.0328 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0156 0.3747 0.372
Brugia malayi FAD binding domain containing protein 0.0156 0.3747 0.743
Trypanosoma cruzi nitrate reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0117 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1379 0.1342
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0328 0.0746
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1423 0.371
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Brugia malayi diaphorase 0.0018 0.0283 0.0463
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0254 0.0546
Onchocerca volvulus 0.0017 0.0254 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0596 0.0555
Leishmania major p450 reductase, putative 0.0156 0.3747 1
Trypanosoma cruzi p450 reductase, putative 0.0156 0.3747 1
Giardia lamblia Hypothetical protein 0.0138 0.3302 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.121 0.1172
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0254 0.0212
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0018 0.0283 0.0186
Leishmania major cytochrome-b5 reductase, putative 0.0018 0.0283 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Entamoeba histolytica cysteine protease, putative 0.0017 0.0254 0.1575
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0053 0.001
Trypanosoma cruzi p450 reductase, putative 0.0018 0.0283 0.0623
Schistosoma mansoni rab6-interacting 0.002 0.0328 0.0287
Loa Loa (eye worm) doublecortin family protein 0.002 0.0328 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0254 0.0443
Brugia malayi FAD binding domain containing protein 0.0096 0.2252 0.4423
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0254 0.0212
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0018 0.0283 0.0623
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0511
Schistosoma mansoni hypothetical protein 0.0406 1 1
Brugia malayi flavodoxin family protein 0.006 0.1333 0.2576
Echinococcus granulosus methionine synthase reductase 0.0096 0.2252 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0062
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Onchocerca volvulus 0.002 0.0328 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0254 0.0212
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0156 0.3747 1
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0018 0.0283 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Trichomonas vaginalis NADPH cytochrome P450, putative 0.006 0.1333 0.2323
Brugia malayi hypothetical protein 0.002 0.0328 0.0554
Schistosoma mansoni rab6-interacting 0.002 0.0328 0.0287
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.006 0.1333 0.3467
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.006 0.1333 0.3467
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0254 0.0212
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Brugia malayi Pre-SET motif family protein 0.003 0.0596 0.1092
Echinococcus granulosus cathepsin L 0.0009 0.0053 0.001
Loa Loa (eye worm) fibroinase 0.0017 0.0254 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1423 0.371
Plasmodium vivax flavodoxin domain containing protein 0.0138 0.3302 0.8797
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0018 0.0283 0.0241
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0053 0.001
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0156 0.3747 0.372
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0596 0.0555
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0018 0.0283 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0254 0.0443
Brugia malayi Cathepsin L-like precursor 0.0017 0.0254 0.0406
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0018 0.0283 0.0623
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0018 0.0283 0.0623
Trypanosoma brucei nitrate reductase, putative 0.0018 0.0283 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1423 0.371
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0086 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0086 0.0044

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Amplitude of the [Ca++]i Transient evoked by 10 uM ATP,AMP and the compound in rat Astrocytes, expressed as (F340 nm/F380 nm); Not Determined ChEMBL. 10639276
Activity (functional) 0 Amplitude of the [Ca++]i Transient evoked by 10 uM ATP,AMP and the compound in NG108-15 Neuroblastoma x Glioma Hybrid cells; Not Determined ChEMBL. 10639276
EC50 (binding) = 10 uM Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes. ChEMBL. 10639276

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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