Detailed information for compound 259890

Basic information

Technical information
  • TDR Targets ID: 259890
  • Name: 5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2- propan-2-yloxy-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide
  • MW: 466.473 | Formula: C22H21F3N2O4S
  • H donors: 2 H acceptors: 3 LogP: 4.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Oc1ccc(cc1C(=O)NCc1ccc(cc1)C(F)(F)F)CC1SC(=O)NC1=O)C
  • InChi: 1S/C22H21F3N2O4S/c1-12(2)31-17-8-5-14(10-18-20(29)27-21(30)32-18)9-16(17)19(28)26-11-13-3-6-15(7-4-13)22(23,24)25/h3-9,12,18H,10-11H2,1-2H3,(H,26,28)(H,27,29,30)
  • InChiKey: NGFBYSBNSWFRFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-isopropoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide
  • 5-[(2,4-dioxo-5-thiazolidinyl)methyl]-2-isopropoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide
  • 5-[(2,4-diketothiazolidin-5-yl)methyl]-2-isopropoxy-N-[4-(trifluoromethyl)benzyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0179 0.029 0.0287
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0134 0.0238
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.0227 0.0224
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi GnHR receptor homolog 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni memapsin-2 (A01 family) 0.0838 0.156 0.156
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Schistosoma mansoni transient receptor potential channel 0.0063 0.0067 0.0067
Echinococcus granulosus nAChR subunit 0.0092 0.0123 0.012
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0179 0.029 0.029
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0041 0.8133
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.5222 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Giardia lamblia DNA repair protein RAD52 0.0343 0.0607 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0227 0.0224
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis serotonin receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.0227 0.0224
Onchocerca volvulus 0.0092 0.0123 0.0745
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0092 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0146 0.0227 0.0224
Echinococcus granulosus alpha 1A adrenergic receptor 0.0146 0.0227 0.0224
Brugia malayi Serotonin receptor 0.0146 0.0227 0.0227
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0041 0.5
Echinococcus granulosus g protein coupled receptor 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Brugia malayi Serotonin receptor 0.0146 0.0227 0.0227
Brugia malayi G-protein coupled receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0233 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0041 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0882 0.1645 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0179 0.029 0.029
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Echinococcus granulosus acetylcholinesterase 0.5222 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0095 0.0129 0.0129
Brugia malayi hypothetical protein 0.0034 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.0227 0.0227
Echinococcus granulosus neuropeptide receptor A26 0.0146 0.0227 0.0224
Schistosoma mansoni nAChR subunit 0.0087 0.0113 0.0113
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0014 0.0011
Schistosoma mansoni opsin-like receptor 0.0146 0.0227 0.0227
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.029 0.029
Echinococcus granulosus g protein coupled receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis para nitrobenzyl esterase 0.0882 0.1645 0.1642
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0882 0.1645 0.5
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0356 0.0632 0.0629
Schistosoma mansoni neuropeptide receptor 0.0146 0.0227 0.0227
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Schistosoma mansoni neuropeptide receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus multilocularis neuroligin 0.0882 0.1645 0.1642
Loa Loa (eye worm) TYRA-2 protein 0.0146 0.0227 0.0227
Mycobacterium tuberculosis Carboxylesterase LipT 0.0882 0.1645 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0113 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0146 0.0227 0.0227
Schistosoma mansoni transient receptor potential channel 0.0063 0.0067 0.0067
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0041 0.0321
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Echinococcus granulosus somatostatin receptor 0.0146 0.0227 0.0224
Schistosoma mansoni hypothetical protein 0.04 0.0716 0.0716
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0011 0.0011
Brugia malayi G protein-coupled receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0087 0.0113 0.011
Echinococcus multilocularis sex peptide receptor 0.0146 0.0227 0.0224
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis nAChR subunit 0.0179 0.029 0.0287
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0048 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Onchocerca volvulus 0.0092 0.0123 0.0745
Echinococcus multilocularis nAChR subunit 0.0092 0.0123 0.012
Echinococcus granulosus tachykinin peptides receptor 99D 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Carboxylesterase family protein 0.0882 0.1645 0.1645
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0011 0.0008
Echinococcus multilocularis carboxylesterase 5A 0.5222 1 1
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.0516 0.0516
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0125 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0072 0.0084 0.0084
Mycobacterium ulcerans carboxylesterase, LipT 0.0882 0.1645 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni gliotactin 0.0882 0.1645 0.1645
Schistosoma mansoni amine GPCR 0.0146 0.0227 0.0227
Echinococcus granulosus nAChR subunit 0.0179 0.029 0.0287
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0146 0.0227 0.0227
Echinococcus granulosus serotonin receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis neuropeptide FF receptor 2 0.0146 0.0227 0.0224
Echinococcus granulosus hypothetical protein 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0041 0.0041
Echinococcus granulosus neuropeptide receptor 0.0146 0.0227 0.0224
Onchocerca volvulus 0.0146 0.0227 0.1382
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0011 0.0011
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni hypothetical protein 0.0084 0.0107 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.0227 0.0224
Brugia malayi follicle stimulating hormone receptor 0.0368 0.0655 0.0655
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.0227 0.0224
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0179 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0011 0.0011
Brugia malayi Dopamine receptor protein 1 0.0146 0.0227 0.0227
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.029 0.029
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.029 0.029
Brugia malayi Cache domain containing protein 0.0072 0.0084 0.0084
Schistosoma mansoni myosin xvIII 0.0146 0.0227 0.0227
Brugia malayi neuropeptide F receptor 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0179 0.029 0.1764
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Echinococcus multilocularis neuropeptide receptor A26 0.0146 0.0227 0.0224
Echinococcus granulosus glycine receptor subunit beta 0.0179 0.029 0.0287
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Echinococcus granulosus G protein coupled receptor 139 0.0146 0.0227 0.0224
Echinococcus multilocularis BC026374 protein (S09 family) 0.0882 0.1645 0.1642
Brugia malayi putative neuropeptide receptor NPR1 0.0146 0.0227 0.0227
Echinococcus granulosus voltage dependent calcium channel subunit 0.0356 0.0632 0.0629
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0146 0.0227 0.1382
Onchocerca volvulus 0.0146 0.0227 0.1382
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0179 0.029 0.0287
Loa Loa (eye worm) GABA receptor subunit 0.0092 0.0123 0.0123
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0041 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0227 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Loa Loa (eye worm) ACC-1 protein 0.0179 0.029 0.029
Schistosoma mansoni amine GPCR 0.0146 0.0227 0.0227
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.0087 0.0113 0.0113
Onchocerca volvulus 0.0146 0.0227 0.1382
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0882 0.1645 0.5
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Carboxylesterase family protein 0.0882 0.1645 0.1645
Echinococcus granulosus peptide allatostatin:somatostatin 0.0146 0.0227 0.0224
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0014 0.0011
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.0227 0.0227
Schistosoma mansoni cpg binding protein 0.003 0.0003 0.0003
Brugia malayi Cation transporter family protein 0.0179 0.029 0.029
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0227 0.0224
Echinococcus granulosus glycine receptor subunit beta 0.0179 0.029 0.0287
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0179 0.029 0.029
Brugia malayi neuropeptide F receptor 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0882 0.1645 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus carboxylesterase 5A 0.5222 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0092 0.0123 0.0123
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni opsin-like receptor 0.0146 0.0227 0.0227
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) melatonin receptor type 1A 0.0146 0.0227 0.0227
Echinococcus multilocularis glycine receptor subunit beta 0.0179 0.029 0.0287
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Onchocerca volvulus 0.0087 0.0113 0.0689
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0227 0.0224
Brugia malayi G-protein coupled receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis neuropeptide s receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.0123 0.0123
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0179 0.029 0.029
Onchocerca volvulus 0.0179 0.029 0.1764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Echinococcus granulosus g protein coupled receptor 0.0146 0.0227 0.0224
Schistosoma mansoni adenoreceptor 0.0146 0.0227 0.0227
Brugia malayi Pepsin A precursor 0.0034 0.0011 0.0011
Schistosoma mansoni opsin-like receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) carboxylesterase 0.5222 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0146 0.0227 0.0224
Echinococcus multilocularis g-protein coupled receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Brugia malayi putative neuropeptide receptor 0.0146 0.0227 0.0227
Echinococcus granulosus sex peptide receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0087 0.0113 0.0689
Schistosoma mansoni neuroligin 3 (S09 family) 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Echinococcus granulosus BC026374 protein S09 family 0.0882 0.1645 0.1642
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0146 0.0227 0.1382
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Dopamine receptor protein 2 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0146 0.0227 0.1382
Brugia malayi AKH receptor 0.0146 0.0227 0.0227
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Brugia malayi Melatonin receptor type 1A 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0123 0.012
Onchocerca volvulus 0.0179 0.029 0.1764
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0179 0.029 0.0287
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0227 0.0224
Echinococcus multilocularis dnaJ subfamily B 0.04 0.0716 0.0713
Echinococcus granulosus glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Loa Loa (eye worm) LGC-31 protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0087 0.0113 0.0113
Brugia malayi sulfakinin receptor protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.5222 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.0087 0.0113 0.0113
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0179 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.0227 0.0224
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0146 0.0227 0.0227
Echinococcus multilocularis fmrfamide receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0011 0.0011
Onchocerca volvulus 0.0882 0.1645 1
Brugia malayi Carboxylesterase family protein 0.5222 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0146 0.0227 0.0227
Brugia malayi Carboxylesterase family protein 0.0882 0.1645 0.1645
Echinococcus granulosus acetylcholinesterase 0.5222 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) carboxylesterase 0.0882 0.1645 0.1645
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.029 0.029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0113 0.0113
Brugia malayi excitatory GABA receptor EXP-1A 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0129 0.0126
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0179 0.029 0.0287
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis serotonin receptor 0.0146 0.0227 0.0224
Entamoeba histolytica hypothetical protein 0.0098 0.0134 0.0238
Echinococcus granulosus g-protein coupled receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.0227 0.0227
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0654 0.1205 0.1205
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0154 0.0154
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.006 0.0061 0.0061
Onchocerca volvulus 0.0034 0.0011 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0173 0.0173
Onchocerca volvulus 0.0882 0.1645 1
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0146 0.0227 0.1382
Brugia malayi Tachykinin-like peptides receptor 99D 0.0146 0.0227 0.0227
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0146 0.0227 0.0227
Schistosoma mansoni BC026374 protein (S09 family) 0.0882 0.1645 0.1645
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus dro:myosuppressin receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0179 0.029 0.029
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni neuropeptide receptor 0.0146 0.0227 0.0227
Echinococcus granulosus 7tm_1 domain containing protein 0.0146 0.0227 0.0224
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0087 0.0113 0.0113
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0067 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0179 0.029 0.029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0146 0.0227 0.0227
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0179 0.029 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Echinococcus multilocularis acetylcholinesterase 0.5222 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi ORL1-like opioid receptor 0.0146 0.0227 0.0227
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0179 0.029 0.029
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus para nitrobenzyl esterase 0.0882 0.1645 0.1642
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus fmrfamide receptor 0.0146 0.0227 0.0224
Echinococcus granulosus orexin receptor type 2 0.0146 0.0227 0.0224
Brugia malayi hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0146 0.0227 0.0227
Schistosoma mansoni nAChR subunit 0.0087 0.0113 0.0113
Schistosoma mansoni acetylcholinesterase 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Schistosoma mansoni neuropeptide f receptor 76f 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Echinococcus multilocularis glycine receptor subunit beta 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Loa Loa (eye worm) acetylcholine receptor protein 0.0087 0.0113 0.0113
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0567 0.1038 0.1038
Brugia malayi larval opioid receptor 0.0146 0.0227 0.0227
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0146 0.0227 0.0224
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0146 0.0227 0.1382
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Echinococcus granulosus neuropeptide FF receptor 2 0.0146 0.0227 0.0224
Brugia malayi Dopamine receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0179 0.029 0.029
Onchocerca volvulus 0.0179 0.029 0.1764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus 7TM GPCR rhodopsin 0.0146 0.0227 0.0224
Echinococcus multilocularis neuropeptide receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0179 0.029 0.0287
Echinococcus multilocularis neuropeptide receptor 0.0146 0.0227 0.0224
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0092 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Onchocerca volvulus Neuropeptide F receptor homolog 0.0146 0.0227 0.1382
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus neuropeptide receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) ACC-1 protein 0.0179 0.029 0.029
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0087 0.0113 0.011
Onchocerca volvulus 0.0146 0.0227 0.1382
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0527 0.0962 1
Schistosoma mansoni biogenic amine receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.5222 1 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0882 0.1645 0.1642
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi Cation transporter family protein 0.0179 0.029 0.029
Echinococcus multilocularis G protein coupled receptor 139 0.0146 0.0227 0.0224
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0654 0.1205 0.1205
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0011 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0227 0.0224
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0011 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Brugia malayi hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0777 0.1442 0.1442
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.0227 0.0224
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0179 0.029 0.029
Echinococcus granulosus allatostatin A receptor 0.0146 0.0227 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0179 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0129 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi G protein-coupled receptor F59B2.13 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0146 0.0227 0.1382
Brugia malayi hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0123 0.012
Onchocerca volvulus 0.0087 0.0113 0.0689
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0146 0.0227 0.0224
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.0227 0.0227
Echinococcus granulosus voltage dependent calcium channel subunit 0.0162 0.0258 0.0255
Brugia malayi hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0113 0.0113
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0113 0.0113
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0129 0.0129
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni histamine h1 receptor 0.0146 0.0227 0.0227
Schistosoma mansoni serine-rich repeat protein 0.0084 0.0107 0.0107
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0179 0.029 0.0287
Schistosoma mansoni amine GPCR 0.0146 0.0227 0.0227
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0882 0.1645 0.1645
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0146 0.0227 0.0227
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.0227 0.0224
Brugia malayi Carboxylesterase family protein 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) acetylcholinesterase 1 0.5222 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0067 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0041 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0113 0.0113
Onchocerca volvulus 0.0882 0.1645 1
Echinococcus multilocularis allatostatin A receptor 0.0146 0.0227 0.0224
Schistosoma mansoni biogenic amine receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) carboxylesterase 0.0882 0.1645 0.1645
Schistosoma mansoni growth hormone secretagogue receptor 0.0146 0.0227 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Onchocerca volvulus 0.0882 0.1645 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0146 0.0227 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.005 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.005 0.0041 0.5
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0155 0.0245 0.0245
Echinococcus multilocularis acetylcholinesterase 0.5222 1 1
Schistosoma mansoni hypothetical protein 0.0146 0.0227 0.0227
Echinococcus granulosus dnaJ subfamily B 0.04 0.0716 0.0713
Schistosoma mansoni acetylcholine receptor-related 0.0087 0.0113 0.0113
Schistosoma mansoni amine GPCR 0.0146 0.0227 0.0227
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0146 0.0227 0.0224
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0034 0.0011 0.0066
Brugia malayi hypothetical protein 0.0882 0.1645 0.1645
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0113 0.0113
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0087 0.0113 0.0113
Schistosoma mansoni amine GPCR 0.0686 0.1266 0.1266
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0008
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0067 0.0064
Schistosoma mansoni acetylcholine receptor subunit beta 0.0087 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Brugia malayi RE15519p 0.0146 0.0227 0.0227
Schistosoma mansoni neuropeptide receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis orexin receptor type 2 0.0146 0.0227 0.0224
Brugia malayi Cation transporter family protein 0.0179 0.029 0.029
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0882 0.1645 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0092 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Brugia malayi hypothetical protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0179 0.029 0.029
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0011
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0087 0.0113 0.011
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0882 0.1645 0.1642
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni cpg binding protein 0.003 0.0003 0.0003
Onchocerca volvulus 0.0146 0.0227 0.1382
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0092 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0087 0.0113 0.0113
Onchocerca volvulus 0.0179 0.029 0.1764
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0146 0.0227 0.0224
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0078 0.0097 0.0097
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0146 0.0227 0.0224
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0368 0.0655 0.0655
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0067 0.0064
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0011 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Onchocerca volvulus 0.0146 0.0227 0.1382
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Echinococcus granulosus neuroligin 0.0882 0.1645 0.1642
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0146 0.0227 0.0224
Echinococcus multilocularis somatostatin receptor 0.0146 0.0227 0.0224
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0146 0.0227 0.0224
Schistosoma mansoni nAChR subunit 0.0179 0.029 0.029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0227 0.0227
Onchocerca volvulus 0.0179 0.029 0.1764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0179 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0343 0.0607 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0146 0.0227 0.0227
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0092 0.0123 0.0123
Brugia malayi hypothetical protein 0.0087 0.0113 0.0113
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.0227 0.0227
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0162 0.0258 0.0255
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.0227 0.0227
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0179 0.029 0.029
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0146 0.0227 0.0227
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.0227 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0882 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0146 0.0227 0.0227
Schistosoma mansoni alpha-1 adrenergic receptor 0.0146 0.0227 0.0227
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0146 0.0227 0.0227
Brugia malayi MH2 domain containing protein 0.0118 0.0173 0.0173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0179 0.029 0.029
Onchocerca volvulus 0.0146 0.0227 0.1382
Schistosoma mansoni transient receptor potential channel 0.0095 0.0129 0.0129
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Echinococcus granulosus neuropeptide s receptor 0.0146 0.0227 0.0224
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0179 0.029 0.0287
Onchocerca volvulus Putative nachr subunit 0.0179 0.029 0.1764

Activities

Activity type Activity value Assay description Source Reference
Decrease in blood glucose (functional) = 45 % Antihyperglycemic activity was determined in obese (ob/ob) mice by po administration at a dose of 10 mg/kg ChEMBL. 10098657
Decrease in blood glucose (functional) = 45 % Antihyperglycemic activity was determined in obese (ob/ob) mice by po administration at a dose of 10 mg/kg ChEMBL. 10098657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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