Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0042 | 0.0104 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0164 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0051 | 0.04 | 0.0389 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0158 | 0.0434 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0499 | 0.1399 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0051 | 0.04 | 0.039 |
Brugia malayi | nuclear receptor RXR | 0.0027 | 0.0184 | 0.0169 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | tailless protein | 0.0024 | 0.0158 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0051 | 0.04 | 0.039 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0051 | 0.04 | 0.1119 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.04 | 0.1119 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | conserved hypotetical protein | 0.0024 | 0.0158 | 0.0142 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.04 | 0.1119 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Brugia malayi | nuclear hormone receptor | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0051 | 0.04 | 0.0389 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0499 | 0.0491 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0195 | 0.0179 |
Echinococcus granulosus | FTZ F1 alpha | 0.0051 | 0.04 | 0.1119 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0051 | 0.04 | 0.0245 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.1333 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1253 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.1061 | 0.9543 | 0.9779 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0164 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0476 | 0.1333 |
Brugia malayi | ecdysteroid receptor | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1253 | 0.1265 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0499 | 0.1399 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0184 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0184 | 0.0168 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0184 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0499 | 0.0492 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0158 | 0.0434 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0051 | 0.04 | 0.0389 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0027 | 0.0184 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0051 | 0.04 | 0.0389 |
Echinococcus granulosus | dnaJ subfamily B | 0.0397 | 0.353 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0209 | 0.0578 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0158 | 0.0434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0024 | 0.0158 | 0.0434 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0051 | 0.04 | 0.1119 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.5 |
Loa Loa (eye worm) | DR-78 | 0.0024 | 0.0158 | 0.0141 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0158 | 0.0434 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0499 | 0.1399 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0164 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0051 | 0.04 | 0.0389 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0184 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0184 | 0.0168 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0499 | 0.0491 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0164 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0195 | 0.018 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0499 | 0.0491 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.1253 | 0.1266 |
Schistosoma mansoni | coup transcription factor | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0024 | 0.0158 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0051 | 0.04 | 0.1119 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0051 | 0.04 | 0.0245 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0051 | 0.04 | 0.1119 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0024 | 0.0158 | 0.0142 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0051 | 0.04 | 0.039 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0021 | 0.0044 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0397 | 0.353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0397 | 0.353 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.1253 | 0.3539 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.1253 | 0.3539 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.0158 | 0.0142 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0024 | 0.0158 | 0.0434 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0027 | 0.0184 | 0.0507 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0499 | 0.0492 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0209 | 0.0578 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0051 | 0.04 | 0.039 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0209 | 0.0578 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0499 | 0.1399 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.0184 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0476 | 0.1333 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0042 | 0.0104 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.0477 | 0.1338 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0024 | 0.0158 | 0.0141 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0164 | 0.0148 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0184 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Schistosoma mansoni | nuclear receptor | 0.0024 | 0.0158 | 0.0434 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0021 | 0.0044 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0051 | 0.04 | 0.1119 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0164 | 0.0147 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0051 | 0.04 | 0.1119 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0042 | 0.0104 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0499 | 0.1399 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0499 | 0.1399 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0184 | 0.0168 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0051 | 0.04 | 0.1119 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0051 | 0.04 | 0.1119 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0051 | 0.04 | 0.0389 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0051 | 0.04 | 0.1119 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0051 | 0.04 | 0.039 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0051 | 0.04 | 0.039 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0024 | 0.0158 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0051 | 0.04 | 0.039 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1085 | 0.9759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0051 | 0.04 | 0.0389 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.0184 | 0.0507 |
Schistosoma mansoni | nuclear hormone receptor | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.0158 | 0.0142 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0051 | 0.04 | 0.039 |
Brugia malayi | nuclear receptor NHR-88 | 0.0051 | 0.04 | 0.039 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0051 | 0.04 | 0.1119 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0164 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0195 | 0.0537 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0051 | 0.04 | 0.039 |
Onchocerca volvulus | 0.0051 | 0.04 | 0.0245 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0051 | 0.04 | 0.039 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0209 | 0.0578 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0024 | 0.0158 | 0.0142 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0051 | 0.04 | 0.1119 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0051 | 0.04 | 0.039 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0024 | 0.0158 | 0.0434 |
Brugia malayi | nuclear receptor NHR-67 | 0.0024 | 0.0158 | 0.0142 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0024 | 0.0158 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0476 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0051 | 0.04 | 0.039 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0027 | 0.0184 | 0.0507 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0086 | 0.0068 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | nuclear hormone receptor | 0.1085 | 0.9759 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0158 | 0.0142 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0499 | 0.0492 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0024 | 0.0158 | 0.0142 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0051 | 0.04 | 0.1119 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0499 | 0.1399 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0051 | 0.04 | 0.1119 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0051 | 0.04 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0051 | 0.04 | 0.039 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0051 | 0.04 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0024 | 0.0158 | 0.0142 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0476 | 1 |
Onchocerca volvulus | 0.0028 | 0.0195 | 0.0037 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0051 | 0.04 | 0.1119 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0024 | 0.0158 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.0389 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0027 | 0.0184 | 0.0507 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.1253 | 0.3539 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0158 | 0.0142 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.0184 | 0.0169 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.042 | 0.8223 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | ecdysone receptor | 0.0024 | 0.0158 | 0.0142 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0164 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0024 | 0.0158 | 0.0434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0158 | 0.0141 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 24.9 mg kg-1 | Compound was tested for antianalgesic activity by phenylquinone writhing method in mice. | ChEMBL. | 6708056 |
ED50 (functional) | = 24.9 mg kg-1 | Compound was tested for antianalgesic activity by phenylquinone writhing method in mice. | ChEMBL. | 6708056 |
Inhibition (functional) | = 12.1 % | Antiinflammatory activity, % inhibition was reported 3 h after carrageenin injection in the hind paw edema test in rats: dose=80 mg/kg. | ChEMBL. | 6708056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.