Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Sigma opioid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0076 | 0.0264 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.2875 | 0.1912 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.2875 | 0.2821 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0151 | 0.2875 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0076 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1058 | 0.3681 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.1191 | 0.1123 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0076 | 0.0264 |
Echinococcus multilocularis | acetylcholinesterase | 0.0151 | 0.2875 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0448 | 0.1329 |
Onchocerca volvulus | 0.0081 | 0.1191 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2875 | 0.1912 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2875 | 0.1912 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0151 | 0.2875 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.2875 | 0.2821 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.1191 | 0.4141 |
Echinococcus multilocularis | acetylcholinesterase | 0.0151 | 0.2875 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0151 | 0.2875 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0151 | 0.2875 | 0.1912 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.1191 | 0.4141 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0076 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.2875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4733 | 0.4021 |
Echinococcus granulosus | carboxylesterase 5A | 0.0151 | 0.2875 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0076 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1058 | 0.3681 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.1191 | 0.3982 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0076 | 0.1058 | 0.3509 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0076 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 uM | Inhibition of [3H]- N-allylnormetazocine ([3H]-NANM) binding to sigma receptor | ChEMBL. | 2542555 |
IC50 (binding) | = 3.8 uM | Inhibition of [3H]- N-allylnormetazocine ([3H]-NANM) binding to sigma receptor | ChEMBL. | 2542555 |
IC50 (binding) | = 17 uM | Inhibition of [3H]-1-[1-(2-thienyl) piperidine ([3H]-TCP) binding to PCP receptor | ChEMBL. | 2542555 |
IC50 (binding) | = 17 uM | Inhibition of [3H]-1-[1-(2-thienyl) piperidine ([3H]-TCP) binding to PCP receptor | ChEMBL. | 2542555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.